pI: 10.0315 |
Length (AA): 103 |
MW (Da): 11447 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 103 | 2cqu (A) | 16 | 115 | 36.00 | 0 | 1 | 1.35 | -0.34 |
2 | 90 | 1hb6 (A) | 1 | 85 | 39.00 | 0 | 1 | 1.41 | -1.7 |
1 | 95 | 3fp5 (A) | 3 | 97 | 43.00 | 0 | 1 | 1.53523 | -1.02 |
1 | 89 | 2lbb (A) | 1 | 86 | 48.00 | 0 | 1 | 1.42338 | -0.21 |
1 | 91 | 3flv (A) | 4 | 94 | 43.00 | 0 | 1 | 1.5214 | -1.27 |
2 | 101 | 2cqu (A) | 16 | 107 | 37.00 | 0 | 1 | 1.37077 | -0.36 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | amastigotes. | Fernandes MC |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_131107)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_21135 | Acyl CoA binding protein |
Brugia malayi | Bm1_13580 | Acyl CoA binding protein |
Caenorhabditis elegans | CELE_C18D11.2 | Protein MAA-1 |
Drosophila melanogaster | Dmel_CG8814 | CG8814 gene product from transcript CG8814-RA |
Homo sapiens | ENSG00000107897 | acyl-CoA binding domain containing 5 |
Leishmania braziliensis | LbrM.17.0610 | hypothetical protein, conserved |
Leishmania braziliensis | LbrM.17.0630 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_170680.1 | Acyl CoA binding protein, putative |
Leishmania donovani | LdBPK_170700.1 | Acyl CoA binding protein, putative |
Leishmania infantum | LinJ.17.0700 | hypothetical protein, conserved |
Leishmania infantum | LinJ.17.0680 | hypothetical protein, conserved |
Leishmania major | LmjF.17.0780 | hypothetical protein, conserved |
Leishmania major | LmjF.17.0620 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.17.0620 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.17.0780 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_07797 | acyl CoA binding protein |
Loa Loa (eye worm) | LOAG_07515 | hypothetical protein |
Mus musculus | ENSMUSG00000026781 | acyl-Coenzyme A binding domain containing 5 |
Neospora caninum | NCLIV_066640 | Diazepam binding inhibitor, splice form 1b, related |
Onchocerca volvulus | OVOC9038 |
|
Schmidtea mediterranea | mk4.000071.07 | |
Trypanosoma brucei gambiense | Tbg972.7.7910 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.7.6770 | Acyl CoA binding protein, putative |
Trypanosoma cruzi | TcCLB.508909.214 | Acyl CoA binding protein, putative |
Trypanosoma cruzi | TcCLB.506517.149 | Acyl CoA binding protein, putative |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.