Detailed view for LmjF.35.4590

Basic information

TDR Targets ID: 21235
Leishmania major, phosphatidylserine decarboxylase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.8643 | Length (AA): 352 | MW (Da): 39463 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02666   Phosphatidylserine decarboxylase

Gene Ontology

Mouse over links to read term descriptions.
GO:0004609   phosphatidylserine decarboxylase activity  
GO:0008654   phospholipid biosynthetic process  

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
143 178 3mxu (A) 59 95 50.00 0.43 0.08 0.370173 2.1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_128421)

Species Accession Gene Product
Arabidopsis thaliana AT4G16700   phosphatidylserine decarboxylase 1
Brugia malayi Bm1_41305   phosphatidylserine decarboxylase proenzyme
Candida albicans CaO19.6045   phosphatidylserine decarboxylase
Candida albicans CaO19.13466   phosphatidylserine decarboxylase
Caenorhabditis elegans CELE_B0361.5   Protein PSD-1, isoform A
Cryptosporidium hominis Chro.30247   phosphatidylserine decarboxylase
Cryptosporidium parvum cgd3_2100   phosphatidylserine decarboxylase, putative
Dictyostelium discoideum DDB_G0276503   phosphatidylserine decarboxylase
Dictyostelium discoideum DDB_G0292748   hypothetical protein
Drosophila melanogaster Dmel_CG5991   CG5991 gene product from transcript CG5991-RA
Echinococcus granulosus EgrG_000129200   phosphatidylserine decarboxylase proenzyme
Echinococcus granulosus EgrG_001170700   phosphatidylserine decarboxylase
Echinococcus multilocularis EmuJ_001170700   phosphatidylserine decarboxylase
Echinococcus multilocularis EmuJ_000129200   phosphatidylserine decarboxylase proenzyme
Giardia lamblia GL50803_16495   Phosphatidylserine decarboxylase proenzyme
Homo sapiens ENSG00000241878   phosphatidylserine decarboxylase
Leishmania braziliensis LbrM.34.4570   phosphatidylserine decarboxylase, putative
Leishmania donovani LdBPK_354660.1   phosphatidylserine decarboxylase, putative
Leishmania infantum LinJ.35.4660   phosphatidylserine decarboxylase, putative
Leishmania major LmjF.35.4590   phosphatidylserine decarboxylase, putative
Leishmania mexicana LmxM.34.4590   phosphatidylserine decarboxylase, putative
Loa Loa (eye worm) LOAG_06821   phosphatidylserine decarboxylase
Mus musculus ENSMUSG00000023452   phosphatidylserine decarboxylase
Neospora caninum NCLIV_047160   hypothetical protein
Oryza sativa 4331292   Os03g0101900
Onchocerca volvulus OVOC8718   Phosphatidylserine decarboxylase proenzyme homolog
Onchocerca volvulus OVOC8713   Phosphatidylserine decarboxylase proenzyme homolog
Plasmodium berghei PBANKA_0828700   phosphatidylserine decarboxylase, putative
Plasmodium falciparum PF3D7_0927900   phosphatidylserine decarboxylase
Plasmodium knowlesi PKNH_0726300   phosphatidylserine decarboxylase
Plasmodium vivax PVX_099840   phosphatidylserine decarboxylase, putative
Plasmodium yoelii PY05588   phosphatidylserine decarboxylase, putative
Saccharomyces cerevisiae YNL169C   phosphatidylserine decarboxylase 1
Schistosoma japonicum Sjp_0200960   ko:K01613 phosphatidylserine decarboxylase [EC4.1.1.65], putative
Schistosoma mansoni Smp_021830   phosphatidylserine decarboxylase
Schmidtea mediterranea mk4.000640.08   Phosphatidylserine decarboxylase proenzyme
Schmidtea mediterranea mk4.008545.04   Phosphatidylserine decarboxylase proenzyme 1
Schmidtea mediterranea mk4.009185.00   Phosphatidylserine decarboxylase proenzyme 1
Trypanosoma brucei gambiense Tbg972.9.5840   phosphatidylserine decarboxylase, putative
Trypanosoma brucei Tb927.9.10080   phosphatidylserine decarboxylase, putative
Trypanosoma congolense TcIL3000_9_3740   phosphatidylserine decarboxylase, putative
Trypanosoma cruzi TcCLB.508459.18   phosphatidylserine decarboxylase, putative
Trypanosoma cruzi TcCLB.407335.9   phosphatidylserine decarboxylase, putative
Trypanosoma cruzi TcCLB.509551.149   phosphatidylserine decarboxylase, putative
Toxoplasma gondii TGME49_225550   phosphatidylserine decarboxylase

Essentiality

LmjF.35.4590 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.1610 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.1610 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.1610 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.1610 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_B0361.5 Caenorhabditis elegans slow growth wormbase
PBANKA_0828700 Plasmodium berghei Essential plasmo
TGME49_225550 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier LmjF.35.4590 (Leishmania major), phosphatidylserine decarboxylase, putative
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