Detailed view for LmjF.02.0630

Basic information

TDR Targets ID: 21306
Leishmania major, gamma-glutamyl phosphate reductase-like protein
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.2154 | Length (AA): 659 | MW (Da): 68551 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

No Pfam domain information for this protein.

Gene Ontology

Mouse over links to read term descriptions.
GO:0016620   oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor  
GO:0016491   oxidoreductase activity  
GO:0055114   oxidation reduction  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
229 659 1o20 (A) 2 414 23.00 0 1 0.82 -0.23
240 650 1o20 (A) 2 409 24.00 0 1 0.98 -0.71
71 232 2l7n (A) 1042 1205 14.00 0 0.01 0.333427 -0.31
74 230 4ut1 (A) 389 536 30.00 0.64 0.01 0.23264 1.59
118 211 3wxx (B) 158 260 10.00 0 0.01 0.22024 -0.11
321 659 2h5g (A) 444 781 31.00 0 1 0.733816 0.63
327 650 1o20 (A) 94 409 27.00 0 1 0.796254 0.06
334 647 4ghk (A) 104 414 32.00 0 1 0.808879 0.3

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_183121)

Species Accession Gene Product
Leishmania braziliensis LbrM.02.0610   gamma-glutamyl phosphate reductase-like protein
Leishmania donovani LdBPK_020600.1   gamma-glutamyl phosphate reductase-like protein
Leishmania infantum LinJ.02.0600   gamma-glutamyl phosphate reductase-like protein
Leishmania major LmjF.02.0630   gamma-glutamyl phosphate reductase-like protein
Leishmania mexicana LmxM.02.0630   gamma-glutamyl phosphate reductase-like protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.02.0630 (Leishmania major), gamma-glutamyl phosphate reductase-like protein
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