Detailed view for LmjF.36.1160

Basic information

TDR Targets ID: 21369
Leishmania major, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.2356 | Length (AA): 370 | MW (Da): 41489 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01875   Memo-like protein

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
92 368 1b4u (B) 5 278 11.00 0 0.93 0.54 -0.14
104 341 1b4u (B) 29 258 10.00 0.000054 0.97 0.52 0.23
46 368 3bcz (A) 7 294 35.00 0 1 1.23057 -0.65
53 368 3bcz (A) 10 294 39.00 0 1 1.25875 -0.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_127479)

Species Accession Gene Product
Arabidopsis thaliana AT2G25280   hypothetical protein
Babesia bovis BBOV_II004360   conserved hypothetical protein
Brugia malayi Bm1_08055   Hypothetical UPF0103 protein C37C3.8 in chromosome V, putative
Candida albicans CaO19.7210   similar to S. cerevisiae YJR008W
Caenorhabditis elegans CELE_C37C3.8   Protein TAG-253, isoform A
Dictyostelium discoideum DDB_G0284869   hypothetical protein
Drosophila melanogaster Dmel_CG8031   CG8031 gene product from transcript CG8031-RA
Echinococcus granulosus EgrG_000806600   protein memo1
Echinococcus granulosus EgrG_000237250   protein memo1
Entamoeba histolytica EHI_024510   hypothetical protein, conserved
Echinococcus multilocularis EmuJ_000806600   protein memo1
Echinococcus multilocularis EmuJ_000237250  
Giardia lamblia GL50803_112932   Hypothetical protein
Homo sapiens ENSG00000162959   mediator of cell motility 1
Leishmania braziliensis LbrM.35.1290   hypothetical protein, conserved
Leishmania donovani LdBPK_361220.1   AmmeMemoRadiSam system protein B, putative
Leishmania infantum LinJ.36.1220   hypothetical protein, conserved
Leishmania major LmjF.36.1160   hypothetical protein, conserved
Leishmania mexicana LmxM.36.1160   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_08678   hypothetical protein
Mus musculus ENSMUSG00000058704   mediator of cell motility 1
Neospora caninum NCLIV_045560   hypothetical protein, conserved
Oryza sativa 4345209   Os08g0299000
Plasmodium berghei PBANKA_0719600   memo-like protein
Plasmodium falciparum PF3D7_0417500   memo-like protein
Plasmodium knowlesi PKNH_0509900   memo-like protein
Plasmodium vivax PVX_089970   hypothetical protein, conserved
Plasmodium yoelii PY04533   Protein of unknown function
Saccharomyces cerevisiae YJR008W   Mho1p
Schistosoma japonicum Sjp_0068640   Protein MEMO1, putative
Schistosoma japonicum Sjp_0068650   ko:K06990 mediator of cell motility 1, putative
Schistosoma mansoni Smp_097240.2   hypothetical protein
Schistosoma mansoni Smp_097240.4   hypothetical protein
Schistosoma mansoni Smp_097240.1   hypothetical protein
Schmidtea mediterranea mk4.005314.00  
Schmidtea mediterranea mk4.005314.01   MEMO1 family protein tag-253
Schmidtea mediterranea mk4.022312.00   Protein MEMO1
Schmidtea mediterranea mk4.013760.00  
Trypanosoma brucei gambiense Tbg972.10.6720   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.5520   AmmeMemoRadiSam system protein B, putative
Trypanosoma congolense TcIL3000_10_4650   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.510299.10   AmmeMemoRadiSam system protein B, putative
Toxoplasma gondii TGME49_227840   Memo family protein
Theileria parva TP04_0550   hypothetical protein, conserved
Trichomonas vaginalis TVAG_013700   conserved hypothetical protein
Trichomonas vaginalis TVAG_068400   conserved hypothetical protein
Trichomonas vaginalis TVAG_202120   protein C2orf4, putative

Essentiality

LmjF.36.1160 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.5520 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.5520 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.5520 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.5520 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_0719600 Plasmodium berghei Dispensable plasmo
TGME49_227840 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.36.1160 (Leishmania major), hypothetical protein, conserved
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