pI: 11.6611 |
Length (AA): 419 |
MW (Da): 47487 |
Paralog Number:
4
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
5 | 373 | 1vq8 (B) | 2 | 337 | 37.00 | 0 | 1 | 1.11467 | 0.95 |
208 | 290 | 5dm6 (B) | 91 | 175 | 39.00 | 0.00078 | 0.08 | 0.145591 | 2.03 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | amastigotes, metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_126874)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G43170 | 60S ribosomal protein L3-1 |
Arabidopsis thaliana | AT1G61580 | 60S ribosomal protein L3-2 |
Babesia bovis | BBOV_I002850 | ribosomal protein L3, putative |
Brugia malayi | Bm1_13895 | 60S ribosomal protein L3 |
Candida albicans | CaO19.9169 | likely cytosolic ribosomal protein similar to S. cerevisiae RPL3 (YOR063W) large subunit protein L3 |
Candida albicans | CaO19.1601 | likely cytosolic ribosomal protein similar to S. cerevisiae RPL3 (YOR063W) large subunit protein L3 |
Caenorhabditis elegans | CELE_F13B10.2 | Protein RPL-3, isoform A |
Cryptosporidium hominis | Chro.50225 | hypothetical protein |
Cryptosporidium parvum | cgd5_1580 | hypothetical protein |
Dictyostelium discoideum | DDB_G0291862 | 60S ribosomal protein L3 |
Drosophila melanogaster | Dmel_CG4863 | Ribosomal protein L3 |
Echinococcus granulosus | EgrG_000700700 | ribosomal protein L3 |
Entamoeba histolytica | EHI_126240 | 60S ribosomal protein L3, putative |
Entamoeba histolytica | EHI_005890 | 60S ribosomal protein L3, putative |
Entamoeba histolytica | EHI_055670 | 60S ribosomal protein L3, putative |
Entamoeba histolytica | EHI_167520 | 60S ribosomal protein L3, putative |
Echinococcus multilocularis | EmuJ_000700700 | ribosomal protein L3 |
Giardia lamblia | GL50803_16525 | Ribosomal protein L3 |
Homo sapiens | 6123 | ribosomal protein L3-like |
Homo sapiens | ENSG00000100316 | ribosomal protein L3 |
Leishmania infantum | LinJ.32.3320 | ribosomal protein L3, putative |
Leishmania infantum | LinJ.34.2730 | ribosomal protein L3, putative |
Leishmania infantum | LinJ.32.3330 | ribosomal protein L3, putative |
Leishmania major | LmjF.34.2900 | ribosomal protein L3, putative |
Leishmania major | LmjF.34.2870 | ribosomal protein L3, putative |
Leishmania major | LmjF.32.3130 | ribosomal protein L3, putative |
Leishmania major | LmjF.34.2880 | ribosomal protein L3, putative |
Leishmania major | LmjF.34.2890 | ribosomal protein L3, putative |
Leishmania mexicana | LmxM.33.2900 | ribosomal protein L3, putative |
Leishmania mexicana | LmxM.33.2870 | ribosomal protein L3, putative |
Leishmania mexicana | LmxM.31.3130 | ribosomal protein L3, putative |
Loa Loa (eye worm) | LOAG_10407 | 60S ribosomal protein L3 |
Mus musculus | ENSMUSG00000002500 | ribosomal protein L3-like |
Mus musculus | ENSMUSG00000060036 | ribosomal protein L3 |
Mus musculus | 433745 | predicted gene 12816 |
Neospora caninum | NCLIV_045800 | 60S ribosomal protein L3, related |
Oryza sativa | 4351604 | Os12g0167900 |
Oryza sativa | 4349879 | Os11g0168200 |
Plasmodium berghei | PBANKA_0511900 | 60S ribosomal protein L3, putative |
Plasmodium falciparum | PF3D7_1027800 | 60S ribosomal protein L3 |
Plasmodium knowlesi | PKNH_0612200 | 60S ribosomal protein L3, putative |
Plasmodium vivax | PVX_111330 | 60S ribosomal protein L3, putative |
Plasmodium yoelii | PY05881 | ribosomal protein L3, putative |
Saccharomyces cerevisiae | YOR063W | ribosomal 60S subunit protein L3 |
Schistosoma japonicum | Sjp_0213900 | ko:K02925 large subunit ribosomal protein L3e, putative |
Schistosoma mansoni | Smp_047200 | 60S ribosomal protein L3 |
Schmidtea mediterranea | mk4.003495.03 | 60S ribosomal protein L3 |
Schmidtea mediterranea | mk4.001411.02 | 60S ribosomal protein L3 |
Trypanosoma brucei gambiense | Tbg972.4.1700 | ribosomal protein L3, putative |
Trypanosoma brucei gambiense | Tbg972.4.1710 | ribosomal protein L3, mitochondrial, putative |
Trypanosoma brucei | Tb927.4.1800 | Mitochondrial ribosomal protein L3 |
Trypanosoma brucei | Tb927.4.1790 | ribosomal protein L3, putative |
Trypanosoma congolense | TcIL3000_4_1450 | ribosomal protein L3, putative |
Trypanosoma congolense | TcIL3000_4_1440 | ribosomal protein L3, mitochondrial, putative |
Trypanosoma cruzi | TcCLB.510879.120 | ribosomal protein L3, putative |
Trypanosoma cruzi | TcCLB.510879.110 | ribosomal protein L3, putative |
Toxoplasma gondii | TGME49_227360 | ribosomal protein RPL3 |
Theileria parva | TP01_0560 | 60S ribosomal protein L3, putative |
Trichomonas vaginalis | TVAG_124190 | 60S ribosomal protein L3, putative |
Trichomonas vaginalis | TVAG_071700 | 50S ribosomal protein L3, putative |
Trichomonas vaginalis | TVAG_125550 | ribosomal protein L3p, putative |
Trichomonas vaginalis | TVAG_059650 | ribosomal protein L3p, putative |
Trichomonas vaginalis | TVAG_013060 | 60S ribosomal protein L3, putative |
Trichomonas vaginalis | TVAG_388910 | 60S ribosomal protein L3, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.4.1790 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.4.1790 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.4.1790 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.4.1790 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F13B10.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F13B10.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F13B10.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F13B10.2 | Caenorhabditis elegans | sterile | wormbase |
YOR063W | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_227360 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.