Detailed view for LmjF.35.1310
Basic information
TDR Targets ID: 21534
Leishmania major, histone H4
Source Database / ID: TriTrypDB GeneDB
Leishmania major, histone H4
Source Database / ID: TriTrypDB GeneDB
pI: 11.1368 |
Length (AA): 100 |
MW (Da): 11439 |
Paralog Number:
6
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
PF15511
Centromere kinetochore component CENP-T histone fold
Gene Ontology
Mouse over links to read term descriptions.
GO:0046982
protein heterodimerization activity GO:0005634 nucleus
GO:0000786 nucleosome
GO:0003677 DNA binding
GO:0006334 nucleosome assembly
Metabolic Pathways
This gene is not mapped to any metabolic pathway in KEGG.
Structural information
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 2 | 100 | 1kx5 (B) | 2 | 101 | 56.00 | 0 | 1 | 1.597 | 0.33 |
| 45 | 92 | 5b0z (D) | 54 | 101 | 23.00 | 0.3 | 0.1 | 0.787 | -0.77 |
Help me make sense of these data.
Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
No structure availble in the PDB for this protein
Expression
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Upper 80-100% percentile | amastigotes. | Fernandes MC |
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Mid 40-60% percentile | metacyclic. | Fernandes MC |
-
Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.
Orthologs
Ortholog group members (OG5_126573)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT1G07820 | histone H4 |
| Arabidopsis thaliana | AT2G28740 | histone H4 |
| Arabidopsis thaliana | AT5G59690 | histone H4 |
| Arabidopsis thaliana | AT3G46320 | histone H4 |
| Arabidopsis thaliana | AT3G45930 | histone H4 |
| Arabidopsis thaliana | AT5G59970 | histone H4 |
| Arabidopsis thaliana | AT3G53730 | histone H4 |
| Babesia bovis | BBOV_III007560 | core histone H2A/H2B/H3/H4 family protein |
| Brugia malayi | Bm1_02515 | histone H4 |
| Brugia malayi | Bm1_36685 | histone H4 |
| Candida albicans | CaO19.1059 | likely histone H4 gene similar to S. cerevisiae histone H4 genes HHF1 (YBR009C) and HHF2 (YNL030W) |
| Candida albicans | CaO19.8661 | likely histone H4 gene similar to S. cerevisiae histone H4 genes HHF1 (YBR009C) and HHF2 (YNL030W) |
| Candida albicans | CaO19.9412 | likely histone H4 gene similar to S. cerevisiae histone H4 genes HHF1 (YBR009C) and HHF2 (YNL030W) |
| Candida albicans | CaO19.1854 | likely histone H4 gene similar to S. cerevisiae histone H4 genes HHF1 (YBR009C) and HHF2 (YNL030W) |
| Caenorhabditis elegans | CELE_K06C4.10 | Protein HIS-18 |
| Caenorhabditis elegans | CELE_C50F4.7 | Protein HIS-37 |
| Caenorhabditis elegans | CELE_K06C4.2 | Protein HIS-28 |
| Caenorhabditis elegans | CELE_T10C6.14 | Protein HIS-1 |
| Caenorhabditis elegans | CELE_B0035.9 | Protein HIS-46 |
| Caenorhabditis elegans | CELE_ZK131.8 | Protein HIS-14 |
| Caenorhabditis elegans | CELE_F07B7.9 | Protein HIS-50 |
| Caenorhabditis elegans | CELE_T23D8.5 | Protein HIS-67 |
| Caenorhabditis elegans | CELE_F22B3.1 | Protein HIS-64 |
| Caenorhabditis elegans | CELE_F17E9.12 | Protein HIS-31 |
| Caenorhabditis elegans | CELE_F54E12.3 | Protein HIS-56 |
| Caenorhabditis elegans | CELE_K03A1.6 | Protein HIS-38 |
| Caenorhabditis elegans | CELE_F45F2.3 | Protein HIS-5 |
| Caenorhabditis elegans | CELE_ZK131.1 | Protein HIS-26 |
| Caenorhabditis elegans | CELE_ZK131.4 | Protein HIS-10 |
| Caenorhabditis elegans | CELE_F55G1.11 | Protein HIS-60 |
| Cryptosporidium hominis | Chro.80597 | hypothetical protein |
| Cryptosporidium parvum | cgd8_5230 | histone H4 |
| Dictyostelium discoideum | DDB_G0277183 | histone H4 |
| Dictyostelium discoideum | DDB_G0276863 | histone H4 |
| Drosophila melanogaster | Dmel_CG33907 | CG33907 gene product from transcript CG33907-RA |
| Drosophila melanogaster | Dmel_CG31611 | CG31611 gene product from transcript CG31611-RA |
| Drosophila melanogaster | Dmel_CG33871 | CG33871 gene product from transcript CG33871-RA |
| Drosophila melanogaster | Dmel_CG33903 | CG33903 gene product from transcript CG33903-RA |
| Drosophila melanogaster | Dmel_CG33885 | CG33885 gene product from transcript CG33885-RA |
| Drosophila melanogaster | Dmel_CG33893 | CG33893 gene product from transcript CG33893-RA |
| Drosophila melanogaster | Dmel_CG33897 | CG33897 gene product from transcript CG33897-RA |
| Drosophila melanogaster | Dmel_CG33879 | CG33879 gene product from transcript CG33879-RA |
| Drosophila melanogaster | Dmel_CG33891 | CG33891 gene product from transcript CG33891-RA |
| Drosophila melanogaster | Dmel_CG33883 | CG33883 gene product from transcript CG33883-RA |
| Drosophila melanogaster | Dmel_CG33899 | CG33899 gene product from transcript CG33899-RA |
| Drosophila melanogaster | Dmel_CG33869 | CG33869 gene product from transcript CG33869-RA |
| Drosophila melanogaster | Dmel_CG33895 | CG33895 gene product from transcript CG33895-RA |
| Drosophila melanogaster | Dmel_CG3379 | Histone H4 replacement |
| Drosophila melanogaster | Dmel_CG33909 | CG33909 gene product from transcript CG33909-RA |
| Drosophila melanogaster | Dmel_CG33875 | CG33875 gene product from transcript CG33875-RA |
| Drosophila melanogaster | Dmel_CG33889 | CG33889 gene product from transcript CG33889-RA |
| Drosophila melanogaster | Dmel_CG33873 | CG33873 gene product from transcript CG33873-RA |
| Drosophila melanogaster | Dmel_CG33877 | CG33877 gene product from transcript CG33877-RA |
| Drosophila melanogaster | Dmel_CG33881 | CG33881 gene product from transcript CG33881-RA |
| Drosophila melanogaster | Dmel_CG33887 | CG33887 gene product from transcript CG33887-RA |
| Drosophila melanogaster | Dmel_CG33905 | CG33905 gene product from transcript CG33905-RA |
| Drosophila melanogaster | Dmel_CG33901 | CG33901 gene product from transcript CG33901-RA |
| Echinococcus granulosus | EgrG_000323100 | histone H4 |
| Echinococcus granulosus | EgrG_000128000 | histone H4 |
| Echinococcus granulosus | EgrG_000748300 | histone H4 |
| Echinococcus granulosus | EgrG_000305000 | expressed protein |
| Entamoeba histolytica | EHI_023230 | histone H4 |
| Echinococcus multilocularis | EmuJ_000385100 | histone H4 |
| Echinococcus multilocularis | EmuJ_000031400 | histone H4 |
| Echinococcus multilocularis | EmuJ_000388100 | histone H4 |
| Echinococcus multilocularis | EmuJ_000384600 | histone H4 |
| Echinococcus multilocularis | EmuJ_000748300 | histone H4 |
| Echinococcus multilocularis | EmuJ_000027700 | histone H4 |
| Echinococcus multilocularis | EmuJ_000323100 | histone H4 |
| Echinococcus multilocularis | EmuJ_000385500 | histone H4 |
| Echinococcus multilocularis | EmuJ_000031300 | histone H4 |
| Echinococcus multilocularis | EmuJ_000323000 | histone H4 |
| Echinococcus multilocularis | EmuJ_000367100 | histone H4 |
| Echinococcus multilocularis | EmuJ_000387100 | histone H4 |
| Echinococcus multilocularis | EmuJ_000305000 | expressed protein |
| Echinococcus multilocularis | EmuJ_000387600 | histone H4 |
| Echinococcus multilocularis | EmuJ_000128000 | histone H4 |
| Echinococcus multilocularis | EmuJ_000386600 | histone H4 |
| Echinococcus multilocularis | EmuJ_000367400 | histone H4 |
| Giardia lamblia | GL50803_135001 | Histone H4 |
| Giardia lamblia | GL50803_135003 | Histone H4 |
| Giardia lamblia | GL50803_135002 | Histone H4 |
| Homo sapiens | ENSG00000274618 | histone cluster 1, H4f |
| Homo sapiens | 554313 | histone cluster 2, H4b |
| Homo sapiens | ENSG00000276966 | histone cluster 1, H4e |
| Homo sapiens | ENSG00000278705 | histone cluster 1, H4b |
| Homo sapiens | ENSG00000158406 | histone cluster 1, H4h |
| Homo sapiens | 8364 | histone cluster 1, H4c |
| Homo sapiens | ENSG00000273542 | histone cluster 1, H4k |
| Homo sapiens | 8370 | histone cluster 2, H4a |
| Homo sapiens | ENSG00000278637 | histone cluster 1, H4a |
| Homo sapiens | ENSG00000277157 | histone cluster 1, H4d |
| Homo sapiens | ENSG00000197238 | histone cluster 1, H4j |
| Homo sapiens | 121504 | histone cluster 4, H4 |
| Homo sapiens | ENSG00000275126 | histone cluster 1, H4l |
| Homo sapiens | 8294 | histone cluster 1, H4i |
| Leishmania braziliensis | LbrM.02.0050 | histone H4 |
| Leishmania braziliensis | LbrM.34.0030 | histone H4, putative |
| Leishmania braziliensis | LbrM.35.0070 | histone H4 |
| Leishmania braziliensis | LbrM.29.2900 | histone H4 |
| Leishmania braziliensis | LbrM.02.0020 | histone H4 |
| Leishmania braziliensis | LbrM.23.1830 | histone H4 |
| Leishmania braziliensis | LbrM.34.0050 | histone H4, putative |
| Leishmania braziliensis | LbrM.31.3630 | histone H4 |
| Leishmania braziliensis | LbrM.15.0010 | histone H4 |
| Leishmania braziliensis | LbrM.35.0020 | histone H4 |
| Leishmania braziliensis | LbrM.34.1230 | histone H4 |
| Leishmania braziliensis | LbrM.35.0130 | histone H4 |
| Leishmania donovani | LdBPK_360020.1 | histone H4 |
| Leishmania donovani | LdBPK_351320.1 | histone H4 |
| Leishmania donovani | LdBPK_060010.1 | histone H4 |
| Leishmania donovani | LdBPK_210020.1 | histone H4 |
| Leishmania donovani | LdBPK_150010.1 | histone H4 |
| Leishmania infantum | LinJ.31.3320 | histone H4 |
| Leishmania infantum | LinJ.06.0010 | histone H4 |
| Leishmania infantum | LinJ.36.0020 | histone H4 |
| Leishmania infantum | LinJ.15.0010 | histone H4 |
| Leishmania infantum | LinJ.35.1320 | histone H4 |
| Leishmania infantum | LinJ.25.2560 | histone H4 |
| Leishmania infantum | LinJ.21.0020 | histone H4 |
| Leishmania major | LmjF.35.1310 | histone H4 |
| Leishmania major | LmjF.36.0020 | histone H4 |
| Leishmania major | LmjF.25.2450 | histone H4 |
| Leishmania major | LmjF.06.0010 | histone H4 |
| Leishmania major | LmjF.15.0010 | histone H4 |
| Leishmania major | LmjF.02.0020 | histone H4 |
| Leishmania major | LmjF.31.3180 | histone H4 |
| Leishmania mexicana | LmxM.36.0020 | histone H4 |
| Leishmania mexicana | LmxM.34.1310 | histone H4 |
| Leishmania mexicana | LmxM.25.2450 | histone H4 |
| Leishmania mexicana | LmxM.30.3180 | histone H4 |
| Leishmania mexicana | LmxM.06.0010 | histone H4 |
| Leishmania mexicana | LmxM.15.0010 | histone H4 |
| Loa Loa (eye worm) | LOAG_10012 | late histone L2 H4 |
| Loa Loa (eye worm) | LOAG_12973 | histone H4 |
| Mus musculus | ENSMUSG00000096010 | histone cluster 4, H4 |
| Mus musculus | 319157 | histone cluster 1, H4f |
| Mus musculus | 319156 | histone cluster 1, H4d |
| Mus musculus | 319158 | histone cluster 1, H4i |
| Mus musculus | 319159 | histone cluster 1, H4j |
| Mus musculus | 319155 | histone cluster 1, H4c |
| Mus musculus | 326620 | histone cluster 1, H4b |
| Mus musculus | ENSMUSG00000060981 | histone cluster 1, H4h |
| Mus musculus | ENSMUSG00000064288 | histone cluster 1, H4k |
| Mus musculus | 102641229 | histone H4-like |
| Mus musculus | 97122 | histone cluster 2, H4 |
| Mus musculus | 326619 | histone cluster 1, H4a |
| Mus musculus | ENSMUSG00000069306 | histone cluster 1, H4m |
| Mus musculus | 319161 | histone cluster 1, H4n |
| Neospora caninum | NCLIV_015920 | Histone H4, related |
| Oryza sativa | 4349248 | Os10g0539500 |
| Oryza sativa | 4339029 | Os05g0462700 |
| Oryza sativa | 4336777 | Os04g0583600 |
| Oryza sativa | 4327457 | Os01g0835900 |
| Oryza sativa | 4330345 | Os02g0684500 |
| Oryza sativa | 4331427 | Os03g0119900 |
| Oryza sativa | 4339049 | Os05g0466600 |
| Oryza sativa | 4347135 | Os09g0433600 |
| Oryza sativa | 4347799 | Os09g0553100 |
| Oryza sativa | 9270544 | Os07g0549900 |
| Onchocerca volvulus | OVOC4571 | Histone H4 homolog |
| Plasmodium berghei | PBANKA_0941900 | histone H4, putative |
| Plasmodium falciparum | PF3D7_1105000 | histone H4 |
| Plasmodium knowlesi | PKNH_0902600 | histon H4, putative |
| Plasmodium vivax | PVX_090930 | histone H4, putative |
| Saccharomyces cerevisiae | YNL030W | histone H4 |
| Saccharomyces cerevisiae | YBR009C | histone H4 |
| Schistosoma japonicum | Sjp_0066230 | Histone H4, putative |
| Schistosoma japonicum | Sjp_0110130 | Histone H4, putative |
| Schistosoma japonicum | Sjp_0016100 | Histone H4, putative |
| Schistosoma japonicum | Sjp_0000370 | Histone H4, putative |
| Schistosoma japonicum | Sjp_0004300 | Histone H4, putative |
| Schistosoma mansoni | Smp_194870 | histone H4 |
| Schistosoma mansoni | Smp_053300 | histone H4 |
| Schistosoma mansoni | Smp_053290 | histone H4 |
| Schistosoma mansoni | Smp_053390 | histone H4 |
| Schmidtea mediterranea | mk4.005158.02 | Histone H4 |
| Schmidtea mediterranea | mk4.001066.07 | Histone H4 |
| Schmidtea mediterranea | mk4.027685.00 | |
| Schmidtea mediterranea | mk4.018714.00 | |
| Schmidtea mediterranea | mk4.013216.00 | Histone H4-like protein type G |
| Schmidtea mediterranea | mk4.021260.01 | Histone H4 |
| Schmidtea mediterranea | mk4.049150.00 | |
| Schmidtea mediterranea | mk4.003066.03 | Histone H4 |
| Schmidtea mediterranea | mk4.017365.01 | |
| Schmidtea mediterranea | mk4.001345.01 | |
| Schmidtea mediterranea | mk4.000809.00 | |
| Schmidtea mediterranea | mk4.017320.01 | Histone H4-like protein type G |
| Schmidtea mediterranea | mk4.003127.04 | Histone H4-like protein type G |
| Trypanosoma brucei gambiense | Tbg972.5.5750 | histone H4, putative |
| Trypanosoma brucei gambiense | Tbg972.5.5760 | histone H4, putative |
| Trypanosoma brucei gambiense | Tbg972.5.5710 | histone H4, putative |
| Trypanosoma brucei gambiense | Tbg972.5.5740 | histone H4, putative |
| Trypanosoma brucei gambiense | Tbg972.5.5720 | histone H4, putative |
| Trypanosoma brucei gambiense | Tbg972.5.5730 | histone H4, putative |
| Trypanosoma brucei | Tb927.5.4200 | histone H4, putative |
| Trypanosoma brucei | Tb927.5.4170 | histone H4, putative |
| Trypanosoma brucei | Tb927.5.4180 | histone H4, putative |
| Trypanosoma brucei | Tb927.5.4210 | histone H4, putative |
| Trypanosoma brucei | Tb927.5.4190 | histone H4, putative |
| Trypanosoma brucei | Tb927.5.4240 | histone H4, putative |
| Trypanosoma brucei | Tb927.5.4260 | histone H4, putative |
| Trypanosoma brucei | Tb927.5.4220 | histone H4, putative |
| Trypanosoma brucei | Tb927.5.4230 | histone H4, putative |
| Trypanosoma brucei | Tb927.5.4250 | histone H4, putative |
| Trypanosoma congolense | TcIL3000_0_14180 | histone H4, putative |
| Trypanosoma congolense | TcIL3000_0_14170 | histone H4, putative |
| Trypanosoma congolense | TcIL3000_5_4880 | histone H4, putative |
| Trypanosoma congolense | TcIL3000_0_44460 | Core histone H2A/H2B/H3/H4, putative |
| Trypanosoma congolense | TcIL3000_5_4830 | histone H4, putative |
| Trypanosoma congolense | TcIL3000_5_4820 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.510351.31 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.507943.40 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.510351.11 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.507943.5 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.507943.20 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.507941.160 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.507601.170 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.507601.150 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.507941.150 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.510351.20 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.507943.30 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.508203.47 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.507943.10 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.507601.160 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.507941.170 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.508203.38 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.508203.29 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.508203.56 | histone H4, putative |
| Trypanosoma cruzi | TcCLB.508203.20 | histone H4, putative |
| Toxoplasma gondii | TGME49_239260 | histone H4 |
| Theileria parva | TP04_0677 | histone H4, putative |
| Theileria parva | TP04_0675 | histone H4, putative |
| Trichomonas vaginalis | TVAG_239320 | histone H4, putative |
| Trichomonas vaginalis | TVAG_085660 | histone H4, putative |
| Trichomonas vaginalis | TVAG_341350 | histone H4, putative |
| Trichomonas vaginalis | TVAG_137930 | histone H4, putative |
| Trichomonas vaginalis | TVAG_270900 | histone H4, putative |
| Trichomonas vaginalis | TVAG_414470 | histone H4, putative |
| Trichomonas vaginalis | TVAG_129720 | histone H4, putative |
| Trichomonas vaginalis | TVAG_100580 | histone H4, putative |
| Trichomonas vaginalis | TVAG_270070 | histone H4, putative |
| Trichomonas vaginalis | TVAG_315310 | histone H4, putative |
| Trichomonas vaginalis | TVAG_452720 | histone H4, putative |
| Trichomonas vaginalis | TVAG_191680 | histone H4, putative |
| Trichomonas vaginalis | TVAG_499010 | histone H4, putative |
| Trichomonas vaginalis | TVAG_351560 | histone H4, putative |
| Trichomonas vaginalis | TVAG_392270 | histone H4, putative |
| Trichomonas vaginalis | TVAG_224660 | histone H4, putative |
| Trichomonas vaginalis | TVAG_211270 | histone H4, putative |
| Trichomonas vaginalis | TVAG_470680 | histone H4, putative |
| Trichomonas vaginalis | TVAG_445260 | histone H4, putative |
| Trichomonas vaginalis | TVAG_399380 | histone H4, putative |
| Trichomonas vaginalis | TVAG_014920 | histone H4, putative |
Essentiality
LmjF.35.1310 has one or more orthologs with essentiality data
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| Tb927.5.4170 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
| Tb927.5.4170 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
| Tb927.5.4170 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
| Tb927.5.4170 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
| CELE_T10C6.14 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_T10C6.14 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_T10C6.14 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_T10C6.14 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_T10C6.14 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F45F2.3 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F45F2.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F45F2.3 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F45F2.3 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_F45F2.3 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F45F2.3 | Caenorhabditis elegans | sterile | wormbase |
| CELE_ZK131.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_ZK131.4 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_ZK131.4 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_ZK131.4 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_ZK131.4 | Caenorhabditis elegans | sterile | wormbase |
| CELE_ZK131.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_ZK131.8 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_ZK131.8 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_ZK131.8 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_ZK131.8 | Caenorhabditis elegans | sterile | wormbase |
| CELE_K06C4.10 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_K06C4.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_K06C4.10 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_K06C4.10 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_K06C4.10 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_K06C4.10 | Caenorhabditis elegans | sterile | wormbase |
| CELE_ZK131.1 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_ZK131.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_ZK131.1 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_ZK131.1 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_ZK131.1 | Caenorhabditis elegans | sterile | wormbase |
| CELE_K06C4.2 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_K06C4.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_K06C4.2 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_K06C4.2 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_K06C4.2 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_K06C4.2 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F17E9.12 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F17E9.12 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F17E9.12 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_F17E9.12 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F17E9.12 | Caenorhabditis elegans | sterile | wormbase |
| CELE_C50F4.7 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_C50F4.7 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_C50F4.7 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_C50F4.7 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_C50F4.7 | Caenorhabditis elegans | sterile | wormbase |
| CELE_K03A1.6 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_K03A1.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_K03A1.6 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_K03A1.6 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_K03A1.6 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_K03A1.6 | Caenorhabditis elegans | sterile | wormbase |
| CELE_B0035.9 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_B0035.9 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_B0035.9 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_B0035.9 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_B0035.9 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F07B7.9 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F07B7.9 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F07B7.9 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F07B7.9 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_F07B7.9 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F07B7.9 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F54E12.3 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F54E12.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F54E12.3 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F54E12.3 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_F54E12.3 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F54E12.3 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F55G1.11 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F55G1.11 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F55G1.11 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_F55G1.11 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_F55G1.11 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F55G1.11 | Caenorhabditis elegans | sterile | wormbase |
| CELE_F22B3.1 | Caenorhabditis elegans | embryonic arrest | wormbase |
| CELE_F22B3.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_F22B3.1 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_F22B3.1 | Caenorhabditis elegans | sterile | wormbase |
| CELE_T23D8.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_T23D8.5 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_T23D8.5 | Caenorhabditis elegans | larval lethal | wormbase |
| CELE_T23D8.5 | Caenorhabditis elegans | slow growth | wormbase |
| CELE_T23D8.5 | Caenorhabditis elegans | sterile | wormbase |
| YBR009C | Saccharomyces cerevisiae | inviable | yeastgenome |
| PBANKA_0941900 | Plasmodium berghei | Essential | plasmo |
| TGME49_239260 | Toxoplasma gondii | Probably essential | sidik |
-
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924 -
keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection -
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource -
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930 -
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan -
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84 -
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
Phenotypes and Validation (curated)
We have no manually annotated phenotypes for this target.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
No validation data for this target
Associated compounds / Druggability
Known modulators for this target
No chemical compounds associated to this gene
Predicted associations
By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model
Assayability
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
Bibliographic References
No literature references available for this target.
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User comments
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