Detailed view for LmjF.36.2670

Basic information

TDR Targets ID: 21615
Leishmania major, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.4923 | Length (AA): 481 | MW (Da): 52501 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 2

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00149   Calcineurin-like phosphoesterase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016787   hydrolase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
169 319 3rl5 (A) 31 181 33.00 0.0000000001 0.93 0.311329 0.75
250 308 4m2i (B) 153 246 36.00 0.49 0.35 0.0490611 2.08

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile amastigotes. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_128827)

Species Accession Gene Product
Brugia malayi Bm1_06685   Ser/Thr protein phosphatase family protein
Caenorhabditis elegans CELE_C25E10.12   Protein C25E10.12
Caenorhabditis elegans CELE_T07D4.2   Protein T07D4.2, isoform A
Drosophila melanogaster Dmel_CG16717   CG16717 gene product from transcript CG16717-RA
Entamoeba histolytica EHI_139350   ser/thr protein phosphatase family protein
Homo sapiens ENSG00000186732   metallophosphoesterase domain containing 1
Homo sapiens ENSG00000066382   metallophosphoesterase domain containing 2
Leishmania braziliensis LbrM.35.2880   hypothetical protein, conserved
Leishmania donovani LdBPK_362800.1   hypothetical protein, conserved
Leishmania infantum LinJ.36.2800   hypothetical protein, conserved
Leishmania major LmjF.36.2670   hypothetical protein, conserved
Leishmania mexicana LmxM.36.2670   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_02847   hypothetical protein
Loa Loa (eye worm) LOAG_13952   hypothetical protein
Mus musculus ENSMUSG00000041708   metallophosphoesterase domain containing 1
Mus musculus ENSMUSG00000016386   metallophosphoesterase domain containing 2
Onchocerca volvulus OVOC6139   UPF0046 protein homolog
Onchocerca volvulus OVOC9817   UPF0046 protein homolog
Schmidtea mediterranea mk4.001193.02  
Schmidtea mediterranea mk4.002218.00  
Trichomonas vaginalis TVAG_RG_DS114146_3   Metallophosphoesterase domain-containing protein, putative
Trichomonas vaginalis TVAG_RG_DS113897_8   Metallophosphoesterase domain-containing protein, putative
Trichomonas vaginalis TVAG_RG_DS113355_8   Metallophosphoesterase domain-containing protein, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.36.2670 (Leishmania major), hypothetical protein, conserved
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