Detailed view for LmjF.31.1530

Basic information

TDR Targets ID: 22027
Leishmania major, protein kinase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.6711 | Length (AA): 2279 | MW (Da): 239137 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 15 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1163 1660 1vzo (A) 24 344 18.00 0 1 -0.48 0.99
1184 1387 2b7a (A) 844 1049 14.00 0 0.23 0.19 -0.21
1465 1640 2f2u (A) 206 360 39.00 0 1 0.24 0.42
1654 1753 1w1g (A) 421 521 23.00 0.00000027 0.18 0.26 -0.2
1148 1670 4wih (A) 2 336 25.00 0 1 -0.208313 1.35
1175 1710 3lij (A) 53 392 25.00 0 1 -0.280609 1.73
1178 1350 3cok (A) 5 194 16.00 0 0.45 0.15411 0.34
1181 1648 5lvo (A) 79 356 34.00 0 1 -0.224447 1.27
1189 1443 3sxs (A) 421 661 12.00 0.000000000006 0.33 0.183091 -0.11
1190 1357 2wtk (C) 54 214 19.00 0 0.98 0.218917 0.5
1432 1668 3c4y (B) 273 508 28.00 0 1 0.253193 0.48
1452 1633 2zv2 (A) 292 446 36.00 0 0.95 0.24806 0.14
1465 1561 3dxn (A) 138 238 45.00 0.000012 0.22 0.259263 1.16
1472 1539 2xk7 (A) 140 209 60.00 0.0014 0.92 0.165538 1.67
1954 2080 2mqa (A) 18 136 13.00 0 0 0.106126 -0.34

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile metacyclic. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile amastigotes. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_183906)

Species Accession Gene Product
Leishmania braziliensis LbrM.31.1740   protein kinase, putative
Leishmania donovani LdBPK_311560.1   protein kinase, putative
Leishmania infantum LinJ.31.1560   protein kinase, putative
Leishmania major LmjF.31.1530   protein kinase, putative
Leishmania mexicana LmxM.30.1530   protein kinase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.7

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0059 1 1
0.0069 0.3067 1
0.0042 0.5 0.5
0.0018 0.5 0.5
0.0007 0.5 0.5
0.0004 0.5 0.5
0.0091 1 0.5
0.0081 0.5 0.5
0.0063 1 1
0.0033 0.5 0.5
0.0059 1 1
0.0062 0.6935 0
0.0008 0.5 0.5
0.0011 1 0.5
0.0029 0.5 0.5
0.0092 1 0.5
0.0007 0.5 0.5
0.0023 0.5 0.5
0.0039 0.9485 0.5
0.0098 0.3242 0.2614
0.0039 0.5 0.5
0.0036 0.5 0.5
0.0061 0.6883 0.5304
0.0026 0.5 0.5
0.0066 0.3101 0
0.0027 1 0.5
0.0016 0.5 0.5
0.0067 0.5 0.5
0.0032 0.5 0.5
0.0093 0.8828 0
0.0056 1 0.5
0.0081 1 0.5
0.0088 0.4477 1
0.0064 0.3377 0
0.0059 1 1
0.0022 0.5 0.5
0.0063 0.7244 0.2543
0.0007 0.5 0.5
0.0033 1 1
0.0016 0.5 0.5
0.0012 0.5 0.5
0.0003 0.5 0.5
0.0012 0.5 0.5
0.0012 0.5 0.5
0.0037 1 0.5
0.0032 0.5 0.5
0.0039 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.31.1530 (Leishmania major), protein kinase, putative
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