pI: 5.0774 |
Length (AA): 575 |
MW (Da): 67555 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 7 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 280 | 1uf3 (A) | 6 | 227 | 15.00 | 0 | 0.88 | 0.38 | -0.3 |
3 | 341 | 4pei (A) | 9 | 349 | 28.00 | 0.0000000026 | 1 | 0.954465 | -0.16 |
3 | 298 | 4pei (A) | 9 | 301 | 34.00 | 0 | 1 | 0.914083 | -0.21 |
416 | 568 | 4uos (A) | 1 | 154 | 19.00 | 0.2 | 0.06 | 0.487387 | -0.97 |
3 | 288 | 4pei (A) | 9 | 284 | 40.00 | 0 | 1 | 0.993091 | -0.54 |
3 | 324 | 4pei (A) | 9 | 321 | 30.00 | 0.000000012 | 1 | 0.9516 | -0.43 |
421 | 574 | 4uos (A) | 2 | 157 | 16.00 | 0.12 | 0.02 | 0.444826 | -0.78 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, early trophozoite, Ring. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, sporozoite, early ring, early schizont, late ring, late trophozoite, Oocyst, Male Gametocyte. | Otto TD PlasmoDB Zanghi G Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | merozoite, Sporozoite, Female Gametocyte. | PlasmoDB Zanghi G Lasonder E |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_128259)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G31770 | RNA Lariat debranching enzyme |
Babesia bovis | BBOV_II006060 | lariat-debranching enzyme, putative |
Brugia malayi | Bm1_23235 | RNA lariat debranching enzyme |
Candida albicans | CaO19.11000 | lariat RNA debranching enzyme |
Candida albicans | CaO19.3506 | lariat RNA debranching enzyme |
Caenorhabditis elegans | CELE_C55B7.8 | Protein DBR-1 |
Cryptosporidium hominis | Chro.30487 | ENSANGP00000013430 |
Cryptosporidium parvum | cgd3_4330 | Dbr1p-like RNA lariat debranching enzyme |
Dictyostelium discoideum | DDB_G0280259 | hypothetical protein |
Drosophila melanogaster | Dmel_CG7942 | lariat debranching enzyme |
Echinococcus granulosus | EgrG_001097300 | lariat debranching enzyme |
Entamoeba histolytica | EHI_062730 | RNA lariat debranching enzyme, putative |
Echinococcus multilocularis | EmuJ_001097300 | lariat debranching enzyme |
Homo sapiens | ENSG00000138231 | debranching RNA lariats 1 |
Leishmania braziliensis | LbrM.17.1030 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_170930.1 | hypothetical protein, conserved |
Leishmania infantum | LinJ.17.0930 | hypothetical protein, conserved |
Leishmania major | LmjF.17.0830 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.17.0830 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_00825 | hypothetical protein |
Loa Loa (eye worm) | LOAG_00501 | hypothetical protein |
Loa Loa (eye worm) | LOAG_15570 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13954 | hypothetical protein |
Mus musculus | ENSMUSG00000032469 | debranching enzyme homolog 1 (S. cerevisiae) |
Neospora caninum | NCLIV_015600 | hypothetical protein |
Oryza sativa | 4333963 | Os03g0725300 |
Plasmodium berghei | PBANKA_1354000 | RNA lariat debranching enzyme, putative |
Plasmodium falciparum | PF3D7_1340600 | RNA lariat debranching enzyme, putative |
Plasmodium knowlesi | PKNH_1260800 | RNA lariat debranching enzyme, putative |
Plasmodium vivax | PVX_082945 | Ser/Thr protein phosphatase family protein |
Plasmodium yoelii | PY04559 | RNA lariat debranching enzyme |
Saccharomyces cerevisiae | YKL149C | Dbr1p |
Schistosoma japonicum | Sjp_0208410 | expressed protein |
Schistosoma mansoni | Smp_007190 | RNA lariat debranching enzyme |
Trypanosoma brucei gambiense | Tbg972.5.3050 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.5.2130 | Lariat debranching enzyme, C-terminal domain containing protein, putative |
Trypanosoma congolense | TcIL3000_5_2020 | hypothetical protein, conserved |
Trypanosoma cruzi | TcCLB.511317.40 | Lariat debranching enzyme, C-terminal domain containing protein, putative |
Toxoplasma gondii | TGME49_238230 | Ser/Thr phosphatase family protein |
Theileria parva | TP02_0548 | RNA lariat debranching enzyme, putative |
Trichomonas vaginalis | TVAG_RG_DS113234_10 | RNA lariat debranching enzyme, putative |
Trichomonas vaginalis | TVAG_RG_DS114334_2 | RNA lariat debranching enzyme, putative |
Trichomonas vaginalis | TVAG_182460 | RNA lariat debranching enzyme, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.2130 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.2130 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.2130 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.2130 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_C55B7.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C55B7.8 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1354000 | Plasmodium berghei | Essential | plasmo |
TGME49_238230 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
7 literature references were collected for this gene.