pI: 10.4334 |
Length (AA): 106 |
MW (Da): 12259 |
Paralog Number:
0
Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 0 hs, Female Gametocyte, Male Gametocyte. | Otto TD Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, Ring. | Otto TD Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | intra-erythrocytic - 8 hs. | Otto TD |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 0-20% percentile | Sporozoite. | Zanghi G |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Ortholog group members (OG5_128371)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G20090 | hypothetical protein |
Babesia bovis | BBOV_II005770 | brain protein 44-like protein, putative |
Brugia malayi | Bm1_46220 | Hypothetical UPF0041 protein R07E5.13 in chromosome III |
Candida albicans | CaO19.252 | member of uncharacterised protein family (UPF0041) similar to S. cerevisiae FMP37 (YGL080W) mitochondrial protein |
Candida albicans | CaO19.7884 | member of uncharacterised protein family (UPF0041) similar to S. cerevisiae FMP37 (YGL080W) mitochondrial protein |
Caenorhabditis elegans | CELE_R07E5.13 | Protein R07E5.13 |
Dictyostelium discoideum | DDB_G0267508 | UPF0041 family protein |
Drosophila melanogaster | Dmel_CG14290 | Mitochondrial pyruvate carrier |
Echinococcus granulosus | EgrG_000626600 | Brain protein 44 protein |
Echinococcus multilocularis | EmuJ_000626600 | Brain protein 44 protein |
Homo sapiens | ENSG00000060762 | mitochondrial pyruvate carrier 1 |
Homo sapiens | 347411 | mitochondrial pyruvate carrier 1-like |
Leishmania braziliensis | LbrM.01.0380 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_010350.1 | Mitochondrial pyruvate carrier 1 |
Leishmania infantum | LinJ.01.0350 | hypothetical protein, conserved |
Leishmania major | LmjF.01.0335 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.01.0335 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_04969 | repeating small protein |
Mus musculus | 667103 | predicted gene 13570 |
Mus musculus | ENSMUSG00000023861 | mitochondrial pyruvate carrier 1 |
Neospora caninum | NCLIV_050160 | cDNA, FLJ92180, highly similar to Homo sapiens brain protein 44 (BRP44), mRNA, related |
Oryza sativa | 4345559 | Os08g0412500 |
Oryza sativa | 4346901 | Os09g0373000 |
Onchocerca volvulus | OVOC8568 | Putative mitochondrial pyruvate carrier 2 |
Plasmodium berghei | PBANKA_1354200 | mitochondrial pyruvate carrier protein 1, putative |
Plasmodium falciparum | PF3D7_1340800 | mitochondrial pyruvate carrier protein 1, putative |
Plasmodium knowlesi | PKNH_1260600 | mitochondrial pyruvate carrier protein 1, putative |
Plasmodium vivax | PVX_082955 | mitochondrial pyruvate carrier protein 1, putative |
Plasmodium yoelii | PY07365 | hypothetical protein |
Saccharomyces cerevisiae | YGL080W | Fmp37p |
Schistosoma japonicum | Sjp_0212100 | Brain protein 44-like protein, putative |
Schistosoma mansoni | Smp_022430 | hypothetical protein |
Trypanosoma brucei gambiense | Tbg972.9.1990 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.9.3780 | Mitochondrial pyruvate carrier 1 |
Trypanosoma cruzi | TcCLB.509337.19 | Mitochondrial pyruvate carrier 1 |
Trypanosoma cruzi | TcCLB.511577.144 | Mitochondrial pyruvate carrier 1 |
Toxoplasma gondii | TGME49_235880 | brain protein 44 family protein |
Theileria parva | TP02_0542 | hypothetical protein, conserved |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.160.2380 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.160.2380 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.160.2380 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb09.160.2380 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_235880 | Toxoplasma gondii | Essentiality uncertain | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.