Detailed view for LmjF.35.3800

Basic information

TDR Targets ID: 22052
Leishmania major, 60S ribosomal protein L23, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 10.7838 | Length (AA): 139 | MW (Da): 14957 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00238   Ribosomal protein L14p/L23e

Gene Ontology

Mouse over links to read term descriptions.
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

Ribosome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 139 1vq8 (K) 1 132 48.00 0 1 1.51 -0.77
8 139 1vq8 (K) 1 132 48.00 0 1 1.59354 -0.76

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_126678)

Species Accession Gene Product
Arabidopsis thaliana AT2G33370   60S ribosomal protein L23B
Arabidopsis thaliana AT5G46160   large subunit ribosomal protein L14
Arabidopsis thaliana AT3G04400   60S ribosomal protein L23
Arabidopsis thaliana AT1G04480   60S ribosomal protein L23
Arabidopsis thaliana ArthCp059   50S ribosomal protein L14
Babesia bovis BBOV_II002750   50S ribosomal subunit protein L14, putative
Babesia bovis BBOV_III006390   ribosomal protein L14p/L23e, putative
Brugia malayi Bm1_46580   60S ribosomal protein L23
Candida albicans CaO19.10998   probable Ribosomal Protein L23 similar to S. cerevisiae RPL23A (YBL087C) and RPL23B (YER117W)
Candida albicans CaO19.5684   likely mitochondrial ribosomal protein similar to S. cerevisiae MRPL38 (YKL170W) large subunit protein (E. coli L14)
Candida albicans CaO19.3504   probable Ribosomal Protein L23 similar to S. cerevisiae RPL23A (YBL087C) and RPL23B (YER117W)
Caenorhabditis elegans CELE_B0336.10   Protein RPL-23
Cryptosporidium hominis Chro.60076   60S ribosomal protein L23
Cryptosporidium parvum cgd6_570   60S ribosomal protein L23
Chlamydia trachomatis CT_518   50S ribosomal protein L14
Dictyostelium discoideum DidioMp29   ribosomal protein L14
Dictyostelium discoideum DDB_G0290315   S60 ribosomal protein L23
Drosophila melanogaster Dmel_CG3661   Ribosomal protein L23
Escherichia coli b3310   50S ribosomal subunit protein L14
Echinococcus granulosus EgrG_000954600   large subunit ribosomal protein 23
Entamoeba histolytica EHI_193330   60S ribosomal protein L23, putative
Entamoeba histolytica EHI_051710   60S ribosomal protein L23, putative
Entamoeba histolytica EHI_196920   60S ribosomal protein L23, putative
Echinococcus multilocularis EmuJ_000954600   large subunit ribosomal protein 23
Giardia lamblia GL50803_10091   Ribosomal protein L23
Homo sapiens 9349   ribosomal protein L23
Leishmania braziliensis LbrM.34.3780   60S ribosomal protein L23, putative
Leishmania braziliensis LbrM.34.3770   60S ribosomal protein L23, putative
Leishmania donovani LdBPK_353840.1   60S ribosomal protein L23, putative
Leishmania infantum LinJ.35.3840   60S ribosomal protein L23, putative
Leishmania major LmjF.35.3800   60S ribosomal protein L23, putative
Leishmania major LmjF.35.3790   60S ribosomal protein L23, putative
Leishmania mexicana LmxM.34.3800   60S ribosomal protein L23, putative
Leishmania mexicana LmxM.34.3790   60S ribosomal protein L23, putative
Loa Loa (eye worm) LOAG_01442   large subunit ribosomal protein 23
Mycobacterium leprae ML1849c   PROBABLE 50S RIBOSOMAL PROTEIN L14 RPLN
Mus musculus 100044627   60S ribosomal protein L23-like
Mus musculus 100862455   60S ribosomal protein L23-like
Mus musculus ENSMUSG00000071415   ribosomal protein L23
Mus musculus 100039086   predicted gene 15032
Mycobacterium tuberculosis Rv0714   50S ribosomal protein L14 RplN
Mycobacterium ulcerans MUL_0804   50S ribosomal protein L14
Neospora caninum NCLIV_055710   60S ribosomal protein L23, putative
Neospora caninum NCLIV_047450   ribosomal protein L14p/L2 domain containing protein, putative
Oryza sativa 4331122   Os02g0814700
Oryza sativa 3131422   50S ribosomal protein L14
Oryza sativa 4352797   Os12g0616200
Oryza sativa 9272666   Os05g0292700
Oryza sativa 4348846   Os10g0466700
Oryza sativa 4331562   Os03g0139100
Plasmodium berghei PBANKA_1233900   mitochondrial ribosomal protein L14 precursor, putative
Plasmodium berghei PBANKA_1346700   60S ribosomal protein L23, putative
Plasmodium falciparum PF3D7_1331800   60S ribosomal protein L23, putative
Plasmodium falciparum PF3D7_0519100   mitochondrial ribosomal protein L14 precursor, putative
Plasmodium knowlesi PKNH_1268700   60S ribosomal protein L23, putative
Plasmodium knowlesi PKNH_1014000   50S ribosomal subunit protein L14, putative
Plasmodium vivax PVX_080290   50S ribosomal subunit protein L14, putative
Plasmodium vivax PVX_082525   60S ribosomal protein L23, putative
Plasmodium yoelii PY07409   60S ribosomal protein L23
Plasmodium yoelii PY06065   LSU ribosomal protein L14P
Saccharomyces cerevisiae YER117W   ribosomal 60S subunit protein L23B
Saccharomyces cerevisiae YKL170W   mitochondrial 54S ribosomal protein YmL38/YmL34
Saccharomyces cerevisiae YBL087C   ribosomal 60S subunit protein L23A
Schistosoma japonicum Sjp_0031920   ko:K02894 large subunit ribosomal protein L23e, putative
Schistosoma mansoni Smp_007900.1   60S ribosomal protein L23
Schmidtea mediterranea mk4.000408.05   60S ribosomal protein L23
Schmidtea mediterranea mk4.091311.00  
Trypanosoma brucei gambiense Tbg972.9.6790   60S ribosomal protein L23, putative
Trypanosoma brucei gambiense Tbg972.9.6800   60S ribosomal protein L23, putative
Trypanosoma brucei Tb927.9.11410   60S ribosomal protein L23, putative
Trypanosoma brucei Tb927.9.11380   60S ribosomal protein L23, putative
Trypanosoma cruzi TcCLB.508461.480   60S ribosomal protein L23, putative
Trypanosoma cruzi TcCLB.508461.490   60S ribosomal protein L23, putative
Toxoplasma gondii TGME49_312090   ribosomal protein RPL23
Toxoplasma gondii TGME49_225250   LSU ribosomal protein L14P, putative
Treponema pallidum TP0199   50S ribosomal protein L14
Theileria parva TP04_0392   50S ribosomal protein L14, putative
Theileria parva TP02_0323   60S ribosomal protein L23, putative
Trichomonas vaginalis TVAG_345430   50S ribosomal protein L14p, putative
Trichomonas vaginalis TVAG_015800   60S ribosomal protein L23, putative
Trichomonas vaginalis TVAG_074940   60S ribosomal protein L23, putative
Trichomonas vaginalis TVAG_345450   50S ribosomal protein L14p, putative
Trichomonas vaginalis TVAG_345440   50S ribosomal protein L14, putative
Trichomonas vaginalis TVAG_024110   50S ribosomal protein L14p, putative
Wolbachia endosymbiont of Brugia malayi Wbm0331   50S ribosomal protein L14

Essentiality

LmjF.35.3800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.2630 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb09.211.2630 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb09.211.2630 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb09.211.2630 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
b3310 Escherichia coli essential goodall
CELE_B0336.10 Caenorhabditis elegans embryonic lethal wormbase
CELE_B0336.10 Caenorhabditis elegans larval arrest wormbase
CELE_B0336.10 Caenorhabditis elegans slow growth wormbase
CELE_B0336.10 Caenorhabditis elegans sterile wormbase
PBANKA_1233900 Plasmodium berghei Essential plasmo
PBANKA_1346700 Plasmodium berghei Essential plasmo
TGME49_312090 Toxoplasma gondii Probably essential sidik
TGME49_225250 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier LmjF.35.3800 (Leishmania major), 60S ribosomal protein L23, putative
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