Detailed view for LmjF.34.3060

Basic information

TDR Targets ID: 22098
Leishmania major, mitochondrial carrier protein-like protein
Source Database / ID:  TriTrypDB  GeneDB

pI: 10.0258 | Length (AA): 358 | MW (Da): 39702 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00153   Mitochondrial carrier protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005488   binding  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
50 350 1okc (A) 2 293 19.00 0 0.09 0.81 -0.02
169 354 4c9h (A) 129 312 38.00 0 0.53 0.678953 0.78

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_127489)

Species Accession Gene Product
Arabidopsis thaliana AT5G61810   ATP-Mg/Pi transporter
Arabidopsis thaliana AT5G51050   mitochondrial substrate carrier family protein
Arabidopsis thaliana AT5G07320   mitochondrial ATP-Mg/Pi transporter
Brugia malayi Bm1_31865   Probable calcium-binding mitochondrial carrier F55A11.4
Candida albicans CaO19.8981   mitochondrial carrier family and EF hand protein similar to S. cerevisiae YNL083W
Candida albicans CaO19.1403   mitochondrial carrier family and EF hand protein similar to S. cerevisiae YNL083W
Caenorhabditis elegans CELE_F17E5.2   Protein F17E5.2
Caenorhabditis elegans CELE_F55A11.4   Protein F55A11.4, isoform A
Dictyostelium discoideum DDB_G0287009   EF-hand domain-containing protein
Drosophila melanogaster Dmel_CG32103   CG32103 gene product from transcript CG32103-RE
Echinococcus granulosus EgrG_001045600   calcium binding mitochondrial carrier protein
Echinococcus granulosus EgrG_000409900   calcium binding mitochondrial carrier protein
Echinococcus multilocularis EmuJ_000409900   calcium binding mitochondrial carrier protein
Echinococcus multilocularis EmuJ_001045600   calcium binding mitochondrial carrier protein
Homo sapiens ENSG00000148339   solute carrier family 25 (mitochondrial carrier
Homo sapiens ENSG00000125648   solute carrier family 25 (mitochondrial carrier
Homo sapiens ENSG00000085491   solute carrier family 25 (mitochondrial carrier
Leishmania braziliensis LbrM.20.2640   mitochondrial carrier protein-like protein
Leishmania donovani LdBPK_342890.1   mitochondrial carrier protein-like protein
Leishmania infantum LinJ.34.2890   mitochondrial carrier protein-like protein
Leishmania major LmjF.34.3060   mitochondrial carrier protein-like protein
Leishmania mexicana LmxM.33.3060   mitochondrial carrier protein-like protein
Mus musculus ENSMUSG00000026819   solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25
Mus musculus ENSMUSG00000040322   solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 24
Mus musculus ENSMUSG00000027880   solute carrier family 25, member 54
Mus musculus ENSMUSG00000046329   solute carrier family 25 (mitochondrial carrier
Oryza sativa 4341470   Os06g0604500
Oryza sativa 4328650   Os02g0201500
Onchocerca volvulus OVOC2434  
Saccharomyces cerevisiae YNL083W   Ca(2+)-binding ATP:ADP antiporter SAL1
Schistosoma japonicum Sjp_0087290   Calcium-binding mitochondrial carrier protein SCaMC-1, putative
Schistosoma mansoni Smp_106060   mitochondrial carrier protein
Schmidtea mediterranea mk4.006053.02  
Schmidtea mediterranea mk4.006053.01   Mitochondrial carrier protein-related
Schmidtea mediterranea mk4.022442.00  
Schmidtea mediterranea mk4.000905.00   Mitochondrial carrier protein-related
Schmidtea mediterranea mk4.011448.00   Mitochondrial carrier protein-related
Schmidtea mediterranea mk4.006863.01   Mitochondrial carrier protein-related
Schmidtea mediterranea mk4.019535.00   Mitochondrial carrier protein-related
Trypanosoma brucei gambiense Tbg972.4.1570   mitochondrial carrier protein, putative
Trypanosoma brucei Tb927.4.1660   mitochondrial carrier protein, putative
Trypanosoma congolense TcIL3000_0_37060   mitochondrial carrier protein, putative
Trypanosoma congolense TcIL3000_4_1250   mitochondrial carrier protein, putative
Trypanosoma cruzi TcCLB.504057.140   ADP/ATP mitochondrial carrier protein, putative
Trichomonas vaginalis TVAG_237680   ADP,ATP carrier protein, putative

Essentiality

LmjF.34.3060 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.4.1660 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.4.1660 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.4.1660 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.4.1660 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_F55A11.4 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier LmjF.34.3060 (Leishmania major), mitochondrial carrier protein-like protein
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