Detailed view for LmjF.35.4790

Basic information

TDR Targets ID: 22119
Leishmania major, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.6374 | Length (AA): 220 | MW (Da): 24777 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF04144   SCAMP family

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0015031   protein transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
69 211 3dh4 (A) 129 274 31.00 0.021 0.06 0.3767 3.72

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_128585)

Species Accession Gene Product
Arabidopsis thaliana AT1G11180   secretory carrier-associated membrane protein 5
Arabidopsis thaliana AT1G61250   secretory carrier-associated membrane protein 3
Arabidopsis thaliana AT1G32050   secretory carrier-associated membrane protein 5
Arabidopsis thaliana AT2G20840   secretory carrier-associated membrane protein 1
Arabidopsis thaliana AT1G03550   secretory carrier-associated membrane protein 2
Brugia malayi Bm1_49815   SCAMP family protein
Caenorhabditis elegans CELE_M01D7.2   Protein SCM-1
Dictyostelium discoideum DDB_G0289075   spore coat protein
Drosophila melanogaster Dmel_CG9195   CG9195 gene product from transcript CG9195-RC
Echinococcus granulosus EgrG_001016100   secretory carrier associated membrane protein
Echinococcus multilocularis EmuJ_001016100   secretory carrier associated membrane protein
Homo sapiens ENSG00000116521   secretory carrier membrane protein 3
Homo sapiens 9522   secretory carrier membrane protein 1
Leishmania donovani LdBPK_354850.1   hypothetical protein, conserved
Leishmania infantum LinJ.35.4850   hypothetical protein, conserved
Leishmania major LmjF.35.4790   hypothetical protein, conserved
Leishmania mexicana LmxM.34.4790   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_08771   hypothetical protein
Mus musculus ENSMUSG00000021687   secretory carrier membrane protein 1
Mus musculus ensembl-mmu:ENSMUSG00000028049   secretory carrier membrane protein 3
Oryza sativa 4339247   Os05g0503000
Oryza sativa 4336849   Os04g0595800
Oryza sativa 4327836   Os01g0780500
Oryza sativa 4333331   Os03g0582200
Oryza sativa 4343617   Os07g0564600
Schistosoma japonicum Sjp_0214490   Secretory carrier-associated membrane protein 1, putative
Schistosoma japonicum Sjp_0045800   IPR007273,SCAMP,domain-containing
Schistosoma japonicum Sjp_0078620   IPR007273,SCAMP,domain-containing
Schistosoma mansoni Smp_013460   SCAMP family
Schmidtea mediterranea mk4.005692.00  
Schmidtea mediterranea mk4.000315.09  
Schmidtea mediterranea mk4.001811.07  
Schmidtea mediterranea mk4.018780.00  
Schmidtea mediterranea mk4.002249.06  
Trypanosoma brucei gambiense Tbg972.9.5610   hypothetical protein, conserved
Trypanosoma brucei Tb927.9.9750   membrane- trafficking protein, putative
Trypanosoma congolense TcIL3000_9_3580   membrane- trafficking protein, putative
Trypanosoma cruzi TcCLB.503687.49   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506885.394   hypothetical protein, conserved
Trichomonas vaginalis TVAG_230210   secretory carrier membrane protein, putative
Trichomonas vaginalis TVAG_034430   secretory carrier membrane protein, putative
Trichomonas vaginalis TVAG_351870   Secretory carrier-associated membrane protein, putative
Trichomonas vaginalis TVAG_498560   secretory carrier membrane protein, putative
Trichomonas vaginalis TVAG_111570   secretory carrier membrane protein, putative

Essentiality

LmjF.35.4790 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.1330 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.1330 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.1330 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.1330 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier LmjF.35.4790 (Leishmania major), hypothetical protein, conserved
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