Detailed view for PF3D7_1347000

Basic information

TDR Targets ID: 2229
Plasmodium falciparum, WD repeat-containing protein 92, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.9628 | Length (AA): 363 | MW (Da): 41374 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00400   WD domain, G-beta repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
6 360 1erj (A) 330 710 19.00 0.000000000044 1 1.05 -0.31
5 359 3i2n (A) 5 353 31.00 0 1 1.39346 -0.46
6 359 3i2n (A) 6 353 38.00 0 1 1.44351 -0.53
326 362 3ow8 (A) 189 224 42.00 0.0039 0.7 0.423428 1.28

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile intra-erythrocytic - 32 hs. Otto TD
Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile gametocyte, merozoite, sporozoite. PlasmoDB
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile early schizont, late ring, late trophozoite, Female Gametocyte. PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, early trophozoite, Oocyst, Ring, Sporozoite. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs. Otto TD
Show/Hide expression data references
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_130008)

Species Accession Gene Product
Dictyostelium discoideum DDB_G0291822   WD40 repeat-containing protein
Drosophila melanogaster Dmel_CG14353   CG14353 gene product from transcript CG14353-RA
Echinococcus granulosus EgrG_000301400   expressed protein
Echinococcus multilocularis EmuJ_000301400   expressed protein
Giardia lamblia GL50803_3531   HZGJ
Homo sapiens ENSG00000243667   WD repeat domain 92
Leishmania braziliensis LbrM.19.1810   hypothetical protein, conserved
Leishmania donovani LdBPK_191580.1   WD domain, G-beta repeat, putative
Leishmania infantum LinJ.19.1580   hypothetical protein, conserved
Leishmania major LmjF.19.1550   hypothetical protein, conserved
Leishmania mexicana LmxM.19.1550   hypothetical protein, conserved
Mus musculus 103784   WD repeat domain 92
Neospora caninum NCLIV_007970   WD domain, G-beta repeat-containing protein, putative
Plasmodium berghei PBANKA_1359900   WD repeat-containing protein 92, putative
Plasmodium falciparum PF3D7_1347000   WD repeat-containing protein 92, putative
Plasmodium knowlesi PKNH_1253900   WD repeat-containing protein 92, putative
Plasmodium vivax PVX_083250   G-beta repeat protein, putative
Plasmodium yoelii PY01132   Unknown protein
Schistosoma japonicum Sjp_0056360   WD repeat-containing protein 92, putative
Schistosoma mansoni Smp_044400   mouse mitotic checkpoint protein-related
Schmidtea mediterranea mk4.004831.00   Mitotic checkpoint protein-related
Trypanosoma brucei gambiense Tbg972.10.19730   hypothetical protein, conserved
Trypanosoma brucei Tb11.v5.0527   WD domain, G-beta repeat, putative
Trypanosoma congolense TcIL3000_0_03870   WD domain, G-beta repeat, putative
Trypanosoma cruzi TcCLB.507211.30   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511301.100   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.511351.20   hypothetical protein, conserved
Toxoplasma gondii TGME49_253550   WD repeat-containing protein 92, putative
Trichomonas vaginalis TVAG_431150   conserved hypothetical protein
Trichomonas vaginalis TVAG_062260   conserved hypothetical protein

Essentiality

PF3D7_1347000 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.16110 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.16110 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.10.16110 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.16110 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_253550 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier PF3D7_1347000 (Plasmodium falciparum), WD repeat-containing protein 92, putative
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