pI: 9.1698 |
Length (AA): 337 |
MW (Da): 36881 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
44 | 326 | 1okc (A) | 3 | 293 | 17.00 | 0 | 0.15 | 0.89 | -0.17 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | amastigotes, metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_127220)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G14040 | 1 |
Arabidopsis thaliana | AT3G48850 | 2 |
Babesia bovis | BBOV_IV003410 | mitochondrial phosphate transporter |
Brugia malayi | Bm1_39280 | Phosphate carrier protein, mitochondrial precursor, putative |
Candida albicans | CaO19.4885 | likely mitochondrial carrier protein similar to S. cerevisiae MIR1 (YJR077C) putative inorganic phosphate transporter |
Candida albicans | CaO19.8973 | likely mitochondrial carrier family protein similar to S. cerevisiae YER053C |
Candida albicans | CaO19.1395 | likely mitochondrial carrier family protein similar to S. cerevisiae YER053C |
Candida albicans | CaO19.12349 | likely mitochondrial carrier protein similar to S. cerevisiae MIR1 (YJR077C) putative inorganic phosphate transporter |
Caenorhabditis elegans | CELE_T05F1.8 | Protein T05F1.8 |
Caenorhabditis elegans | CELE_C33F10.12 | Protein C33F10.12 |
Caenorhabditis elegans | CELE_F01G4.6 | Protein F01G4.6, isoform B |
Cryptosporidium hominis | Chro.20060 | PfMPC |
Cryptosporidium parvum | cgd2_520 | mitochondrial phosphate translocator |
Dictyostelium discoideum | DDB_G0293646 | mitochondrial substrate carrier family protein |
Dictyostelium discoideum | DDB_G0295753 | mitochondrial substrate carrier family protein |
Drosophila melanogaster | Dmel_CG9090 | CG9090 gene product from transcript CG9090-RA |
Drosophila melanogaster | Dmel_CG4994 | Mitochondrial phosphate carrier protein |
Echinococcus granulosus | EgrG_000146400 | mitochondrial phosphate carrier protein |
Echinococcus multilocularis | EmuJ_000146400 | mitochondrial phosphate carrier protein |
Echinococcus multilocularis | EmuJ_000137900 | voltage dependent calcium channel |
Homo sapiens | ENSG00000075415 | solute carrier family 25 (mitochondrial carrier |
Leishmania braziliensis | LbrM.34.4400 | mitochondrial phosphate transporter, putative |
Leishmania braziliensis | LbrM.34.4410 | mitochondrial phosphate transporter, putative |
Leishmania infantum | LinJ.35.4500 | mitochondrial phosphate transporter, putative |
Leishmania infantum | LinJ.35.4490 | mitochondrial phosphate transporter, putative |
Leishmania major | LmjF.35.4430 | mitochondrial phosphate transporter, putative |
Leishmania major | LmjF.35.4420 | mitochondrial phosphate transporter, putative |
Leishmania mexicana | LmxM.34.4430 | mitochondrial phosphate transporter, putative |
Loa Loa (eye worm) | LOAG_00237 | hypothetical protein |
Mus musculus | ENSMUSG00000061904 | solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 |
Mus musculus | 102641364 | phosphate carrier protein, mitochondrial-like |
Neospora caninum | NCLIV_067010 | Mitochondrial phosphate carrier protein, related |
Oryza sativa | 4335983 | Os04g0448800 |
Oryza sativa | 4330845 | Os02g0767500 |
Oryza sativa | 4347248 | Os09g0454600 |
Oryza sativa | 4340459 | Os06g0210500 |
Onchocerca volvulus | OVOC4957 | Phosphate carrier protein, mitochondrial homolog |
Plasmodium berghei | PBANKA_0601100 | mitochondrial phosphate carrier protein, putative |
Plasmodium falciparum | PF3D7_1202200 | mitochondrial phosphate carrier protein |
Plasmodium knowlesi | PKNH_1302100 | mitochondrial phosphate carrier protein, putative |
Plasmodium vivax | PVX_084135 | mitochondrial carrier protein, putative |
Plasmodium yoelii | PY00463 | PfMPC |
Saccharomyces cerevisiae | YER053C | Pic2p |
Saccharomyces cerevisiae | YJR077C | Mir1p |
Schistosoma japonicum | Sjp_0071850 | Phosphate carrier protein, mitochondrial precursor, putative |
Schistosoma mansoni | Smp_083720 | mitochondrial phosphate carrier protein |
Schmidtea mediterranea | mk4.000708.07 | Putative mitochondrial phosphate carrier protein |
Trypanosoma brucei gambiense | Tbg972.9.5970 | mitochondrial carrier protein, putative,mitochondrial phosphate transporter, putative |
Trypanosoma brucei | Tb927.9.10310 | mitochondrial carrier protein 11 |
Trypanosoma congolense | TcIL3000_9_3880 | mitochondrial phosphate transporter, putative |
Trypanosoma cruzi | TcCLB.509551.30 | mitochondrial phosphate transporter, putative |
Toxoplasma gondii | TGME49_278990 | phosphate carrier, putative |
Theileria parva | TP01_1100 | mitochondrial phosphate carrier, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.211.1750 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.211.1750 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.211.1750 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.211.1750 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F01G4.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F01G4.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F01G4.6 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F01G4.6 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_0601100 | Plasmodium berghei | Essential | plasmo |
TGME49_278990 | Toxoplasma gondii | Probably essential | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.