pI: 7.5999 |
Length (AA): 507 |
MW (Da): 56466 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 7
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
193 | 506 | 1v54 (A) | 116 | 457 | 16.00 | 0 | 0.04 | 0.69 | -0.97 |
18 | 226 | 5cwi (A) | 6 | 227 | 10.00 | 0.17 | 0.05 | 0.540529 | -0.91 |
175 | 266 | 2h2w (A) | 60 | 148 | 28.00 | 0.29 | 0.1 | 0.24066 | 1.12 |
226 | 506 | 3wxw (A) | 100 | 380 | 31.00 | 0 | 0.59 | 0.877441 | -0.11 |
313 | 363 | 4bxs (A) | 193 | 251 | 35.00 | 0.42 | 0.11 | 0.0607917 | 2.82 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | metacyclic. | Fernandes MC |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | amastigotes. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_127242)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G20270 | heptahelical transmembrane protein1 |
Arabidopsis thaliana | AT4G30850 | heptahelical transmembrane protein2 |
Arabidopsis thaliana | AT4G37680 | heptahelical transmembrane protein HHP4 |
Arabidopsis thaliana | AT2G24150 | heptahelical protein 3 |
Arabidopsis thaliana | AT4G38320 | heptahelical protein 5 |
Brugia malayi | Bm1_38245 | ADIPOR-like receptor C43G2.1 |
Brugia malayi | Bm1_19050 | ADIPOR-like receptor C43G2.1 |
Candida albicans | CaO19.7716 | Haemolysin III-related protein similar to S. cerevisiae YDR492W and PHO36 (YOL002C) integral membrane protein involved in phospa |
Candida albicans | CaO19.55 | Haemolysin III-related protein similar to S. cerevisiae YDR492W and PHO36 (YOL002C) integral membrane protein involved in phospa |
Caenorhabditis elegans | CELE_Y32H12A.5 | Protein PAQR-2 |
Caenorhabditis elegans | CELE_C43G2.1 | Protein PAQR-1 |
Dictyostelium discoideum | DDB_G0293072 | hypothetical protein |
Drosophila melanogaster | Dmel_CG5315 | Adiponectin receptor |
Echinococcus granulosus | EgrG_001023750 | Hly III |
Echinococcus granulosus | EgrG_000869800 | adiponectin receptor |
Echinococcus multilocularis | EmuJ_000869800 | adiponectin receptor |
Echinococcus multilocularis | EmuJ_001023700 | Hly III |
Homo sapiens | ENSG00000006831 | adiponectin receptor 2 |
Homo sapiens | ENSG00000159346 | adiponectin receptor 1 |
Leishmania braziliensis | LbrM.35.5750 | hypothetical protein, conserved |
Leishmania braziliensis | LbrM.35.5790 | hypothetical protein, conserved |
Leishmania braziliensis | LbrM.35.5780 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_365760.1 | Haemolysin-III related, putative |
Leishmania donovani | LdBPK_365750.1 | Haemolysin-III related, putative |
Leishmania donovani | LdBPK_365740.1 | Haemolysin-III related, putative |
Leishmania infantum | LinJ.36.5750 | hypothetical protein, conserved |
Leishmania infantum | LinJ.36.5760 | hypothetical protein, conserved |
Leishmania infantum | LinJ.36.5740 | hypothetical protein, conserved |
Leishmania major | LmjF.36.5500 | hypothetical protein, conserved |
Leishmania major | LmjF.36.5510 | hypothetical protein, conserved |
Leishmania major | LmjF.36.5520 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.36.5510 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.36.5520 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_06306 | adiponectin receptor 1b |
Loa Loa (eye worm) | LOAG_03847 | adipor-like receptor |
Mus musculus | 72674 | adiponectin receptor 1 |
Mus musculus | ensembl-mmu:ENSMUSG00000030168 | adiponectin receptor 2 |
Oryza sativa | 4352324 | Os12g0511200 |
Oryza sativa | 4332161 | Os03g0232900 |
Oryza sativa | 4328501 | Os02g0179500 |
Oryza sativa | 4341641 | Os06g0643700 |
Oryza sativa | 4341697 | Os06g0652200 |
Saccharomyces cerevisiae | YDR492W | Izh1p |
Saccharomyces cerevisiae | YOL002C | Izh2p |
Schistosoma japonicum | Sjp_0018340 | ko:K07297 adiponectin receptor, putative |
Schistosoma japonicum | Sjp_0124820 | ADIPOR-like receptor CG5315, putative |
Schistosoma japonicum | Sjp_0200390 | ADIPOR-like receptor CG5315, putative |
Schistosoma japonicum | Sjp_0302860 | ADIPOR-like receptor CG5315, putative |
Schistosoma mansoni | Smp_045410 | adiponectin receptor |
Schistosoma mansoni | Smp_045420 | adiponectin receptor |
Schistosoma mansoni | Smp_057130 | adiponectin receptor |
Schmidtea mediterranea | mk4.001382.02 | Adiponectin receptor protein |
Schmidtea mediterranea | mk4.010777.00 | Adiponectin receptor protein |
Schmidtea mediterranea | mk4.004363.02 | |
Schmidtea mediterranea | mk4.005338.00 | Adiponectin receptor protein |
Schmidtea mediterranea | mk4.003161.02 | Adiponectin receptor protein |
Schmidtea mediterranea | mk4.010951.00 | |
Trypanosoma brucei gambiense | Tbg972.10.11400 | hypothetical protein, conserved |
Trypanosoma brucei gambiense | Tbg972.10.11390 | adiponectin receptor protein 1 |
Trypanosoma brucei | Tb927.10.9300 | adiponectin receptor protein 1 |
Trypanosoma brucei | Tb927.10.9310 | Haemolysin-III related, putative |
Trypanosoma congolense | TcIL3000_10_8080 | hypothetical protein, conserved |
Trypanosoma congolense | TcIL3000_10_8070 | adiponectin receptor protein 1 |
Trypanosoma cruzi | TcCLB.504137.140 | Haemolysin-III related, putative |
Trypanosoma cruzi | TcCLB.509799.100 | Haemolysin-III related, putative |
Trypanosoma cruzi | TcCLB.504137.150 | Haemolysin-III related, putative |
Trypanosoma cruzi | TcCLB.509799.90 | Haemolysin-III related, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.9300 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.9300 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.9300 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.9300 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.10.9310 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.9310 | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.9310 | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.10.9310 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y32H12A.5 | Caenorhabditis elegans | sterile | wormbase |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | adiponectin receptor 1 | Compounds | References |
Homo sapiens | adiponectin receptor 2 | Compounds | References |