Detailed view for LmjF.36.1690

Basic information

TDR Targets ID: 22784
Leishmania major, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.0482 | Length (AA): 308 | MW (Da): 33550 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF09768   Peptidase M76 family

Gene Ontology

Mouse over links to read term descriptions.
GO:0004222   metalloendopeptidase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_128965)

Species Accession Gene Product
Arabidopsis thaliana AT3G03420   Ku70-binding family protein
Candida albicans CaO19.9789   has neutral zinc metallopeptidases signature
Candida albicans CaO19.2249   has neutral zinc metallopeptidases signature
Dictyostelium discoideum DDB_G0270738   hypothetical protein
Drosophila melanogaster Dmel_CG5131   CG5131 gene product from transcript CG5131-RA
Homo sapiens ENSG00000166896   XRCC6 binding protein 1
Leishmania braziliensis LbrM.35.1880   hypothetical protein, conserved
Leishmania donovani LdBPK_361770.1   Peptidase M76 family, putative
Leishmania infantum LinJ.36.1770   hypothetical protein, conserved
Leishmania major LmjF.36.1690   hypothetical protein, conserved
Leishmania mexicana LmxM.36.1690   hypothetical protein, conserved
Mus musculus ENSMUSG00000025436   XRCC6 binding protein 1
Neospora caninum NCLIV_029840   hypothetical protein, conserved
Oryza sativa 4336195   Os04g0482700
Oryza sativa 4352004   Os12g0288900
Plasmodium berghei PBANKA_1305600   mitochondrial inner membrane protease ATP23, putative
Plasmodium falciparum PF3D7_1441700   mitochondrial inner membrane protease ATP23, putative
Plasmodium knowlesi PKNH_1240600   mitochondrial inner membrane protease ATP23, putative
Plasmodium vivax PVX_118405   metalloprotease, putative
Plasmodium yoelii PY01294   Unknown protein
Saccharomyces cerevisiae YNR020C   Atp23p
Trypanosoma brucei gambiense Tbg972.10.7490   hypothetical protein, conserved
Trypanosoma brucei Tb927.10.6120   Peptidase M76 family, putative
Trypanosoma congolense TcIL3000_10_5170   Peptidase M76 family, putative
Trypanosoma cruzi TcCLB.507639.70   Peptidase M76 family, putative
Trypanosoma cruzi TcCLB.503781.40   Peptidase M76 family, putative
Toxoplasma gondii TGME49_257110   hypothetical protein

Essentiality

LmjF.36.1690 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.6120 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.6120 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.6120 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.10.6120 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_1305600 Plasmodium berghei Slow plasmo
TGME49_257110 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.36.1690 (Leishmania major), hypothetical protein, conserved
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