Detailed view for LmjF.32.0780

Basic information

TDR Targets ID: 23133
Leishmania major, protein kinase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.2177 | Length (AA): 1141 | MW (Da): 125783 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 10 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
763 1132 2acx (A) 91 446 20.00 0 1 0.48 0.04
855 1137 1vjy (A) 203 497 24.00 0 1 0.44 -1.06
723 1105 5dzc (A) 390 772 23.00 0 1 0.44497 0.8
727 1135 2c0t (A) 96 493 20.00 0 1 0.398757 0.89
852 1141 4ow8 (A) 9 283 24.00 0 1 0.503463 -0.5
858 1122 1xjd (A) 381 621 25.00 0 1 0.446552 -0.15
863 1068 3dtc (A) 150 349 41.00 0.000000000012 0.53 0.308743 0.65
863 1068 4uy9 (A) 150 349 37.00 0 1 0.524743 0.06
864 1136 5hes (A) 23 264 35.00 0 1 0.377464 0.22
869 1000 4o1p (A) 375 501 24.00 0.000000034 0.95 0.339988 -0.5

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile metacyclic. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile amastigotes. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_183954)

Species Accession Gene Product
Leishmania braziliensis LbrM.32.0870   protein kinase, putative
Leishmania donovani LdBPK_320820.1   protein kinase, putative
Leishmania infantum LinJ.32.0820   protein kinase, putative
Leishmania major LmjF.32.0780   protein kinase, putative
Leishmania mexicana LmxM.31.0780   protein kinase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Methanobacterium thermoautotrophicum Carbonic anhydrase 176 aa 19.9% 141 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0093 0.8828 0
0.0032 0.5 0.5
0.0056 1 0.5
0.0088 0.4477 1
0.0081 1 0.5
0.0064 0.3377 0
0.0022 0.5 0.5
0.0059 1 1
0.0063 0.7244 0.2543
0.0007 0.5 0.5
0.0016 0.5 0.5
0.0033 1 1
0.0012 0.5 0.5
0.0012 0.5 0.5
0.0003 0.5 0.5
0.0012 0.5 0.5
0.0037 1 0.5
0.0039 0.5 0.5
0.0032 0.5 0.5
0.0059 1 1
0.0069 0.3067 1
0.0018 0.5 0.5
0.0042 0.5 0.5
0.0007 0.5 0.5
0.0081 0.5 0.5
0.0091 1 0.5
0.0004 0.5 0.5
0.0063 1 1
0.0033 0.5 0.5
0.0059 1 1
0.0062 0.6935 0
0.0011 1 0.5
0.0092 1 0.5
0.0029 0.5 0.5
0.0008 0.5 0.5
0.0039 0.9485 0.5
0.0098 0.3242 0.2614
0.0007 0.5 0.5
0.0023 0.5 0.5
0.0036 0.5 0.5
0.0061 0.6883 0.5304
0.0039 0.5 0.5
0.0026 0.5 0.5
0.0066 0.3101 0
0.0067 0.5 0.5
0.0016 0.5 0.5
0.0027 1 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.32.0780 (Leishmania major), protein kinase, putative
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