pI: 9.2609 |
Length (AA): 345 |
MW (Da): 37772 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 10 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 78 | 1hdj () | 0 | 75 | 62.00 | 0 | 1 | 1.05 | -1.39 |
2 | 99 | 2ctq (A) | 19 | 112 | 23.00 | 0 | 1 | 0.63 | -0.85 |
4 | 70 | 2ctp (A) | 8 | 72 | 54.00 | 0 | 1 | 0.99 | -1.93 |
103 | 330 | 1nlt (A) | 110 | 337 | 25.00 | 0 | 1 | 0.73 | 1.31 |
254 | 343 | 1xao (A) | 259 | 352 | 23.00 | 0.0000000000031 | 0.97 | 0.51 | -0.43 |
1 | 77 | 1hdj (A) | 0 | 74 | 63.00 | 0 | 1 | 1.07639 | -1.66 |
3 | 344 | 4j80 (A) | 5 | 266 | 30.00 | 0.000000000036 | 1 | 0.937304 | 1.33 |
4 | 342 | 4j80 (A) | 6 | 264 | 42.00 | 0 | 1 | 1.14851 | 0.46 |
4 | 72 | 3ucs (C) | 5 | 71 | 46.00 | 0 | 1 | 0.9672 | -2.53 |
175 | 342 | 2q2g (A) | 7 | 177 | 35.00 | 0 | 1 | 0.918857 | -0.3 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | amastigotes, metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_126773)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G08910 | DnaJ domain-containing protein |
Arabidopsis thaliana | AT2G20560 | DNAJ heat shock family protein |
Arabidopsis thaliana | AT5G25530 | putative DNAJ heat shock protein |
Arabidopsis thaliana | AT1G10350 | putative DNAJ heat-shock protein |
Arabidopsis thaliana | AT1G59725 | putative DNAJ heat shock protein |
Babesia bovis | BBOV_II006560 | protein with DnaJ domain, DNJ1/SIS1 family |
Brugia malayi | Bm1_16640 | DnaJ homolog subfamily B member 4 |
Candida albicans | CaO19.3861 | DnaJ-like protein similar to S. cerevisiae SIS1 (YNL007C) Sit4 suppressor |
Candida albicans | CaO19.11342 | DnaJ-like protein similar to S. cerevisiae SIS1 (YNL007C) HSP40 family chaperone |
Caenorhabditis elegans | CELE_F54D5.8 | Protein DNJ-13 |
Cryptosporidium hominis | Chro.20195 | heat shock 40 kDa protein |
Cryptosporidium parvum | cgd2_1800 | heat shock 40 kDa protein, putative |
Drosophila melanogaster | Dmel_CG10578 | DnaJ-like-1 |
Drosophila melanogaster | Dmel_CG5001 | CG5001 gene product from transcript CG5001-RB |
Echinococcus granulosus | EgrG_000614200 | dnaJ subfamily B |
Echinococcus granulosus | EgrG_000658700 | dnaJ subfamily B 3 |
Echinococcus granulosus | EgrG_000657800 | dnaJ subfamily B 3 |
Entamoeba histolytica | EHI_187000 | DnaJ family protein |
Entamoeba histolytica | EHI_183280 | DnaJ family protein |
Echinococcus multilocularis | EmuJ_000657800 | |
Echinococcus multilocularis | EmuJ_000658700 | dnaJ subfamily B 3 |
Echinococcus multilocularis | EmuJ_000614200 | dnaJ subfamily B |
Giardia lamblia | GL50803_17483 | Chaperone protein dnaJ |
Homo sapiens | ENSG00000187726 | DnaJ (Hsp40) homolog, subfamily B, member 13 |
Homo sapiens | ENSG00000137094 | DnaJ (Hsp40) homolog, subfamily B, member 5 |
Homo sapiens | 11080 | DnaJ (Hsp40) homolog, subfamily B, member 4 |
Homo sapiens | ENSG00000132002 | DnaJ (Hsp40) homolog, subfamily B, member 1 |
Leishmania braziliensis | LbrM.35.6590 | chaperone protein DNAj, putative |
Leishmania donovani | LdBPK_366530.1 | chaperone protein DnaJ, putative |
Leishmania infantum | LinJ.36.6530 | chaperone protein DNAj, putative |
Leishmania major | LmjF.36.6270 | chaperone protein DNAj, putative |
Leishmania mexicana | LmxM.36.6270 | chaperone protein DNAj, putative |
Loa Loa (eye worm) | LOAG_01435 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08423 | dnaJ-class molecular chaperone |
Mus musculus | ENSMUSG00000005483 | DnaJ (Hsp40) homolog, subfamily B, member 1 |
Mus musculus | ENSMUSG00000036052 | DnaJ (Hsp40) homolog, subfamily B, member 5 |
Mus musculus | ENSMUSG00000030708 | DnaJ (Hsp40) related, subfamily B, member 13 |
Mus musculus | ENSMUSG00000028035 | DnaJ (Hsp40) homolog, subfamily B, member 4 |
Neospora caninum | NCLIV_039960 | hypothetical protein |
Oryza sativa | 4329116 | Os02g0306900 |
Oryza sativa | 4326364 | Os01g0239100 |
Oryza sativa | 4339609 | Os05g0562300 |
Oryza sativa | 4344726 | Os08g0161900 |
Onchocerca volvulus | OVOC11163 |
|
Plasmodium berghei | PBANKA_0310000 | protein SIS1, putative |
Plasmodium falciparum | PF3D7_0213100 | protein SIS1 |
Plasmodium falciparum | PF3D7_0501100 | heat shock protein 40, type II |
Plasmodium falciparum | PF3D7_0201800 | knob associated heat shock protein 40 |
Plasmodium knowlesi | PKNH_1246700 | DNAJ like protein, putative |
Plasmodium knowlesi | PKNH_0407900 | protein SIS1, putative |
Plasmodium vivax | PVX_002875 | protein SIS1, putative |
Plasmodium vivax | PVX_118690 | 40 kDa heat shock protein, putative |
Plasmodium yoelii | PY02986 | DnaJ C terminal region, putative |
Saccharomyces cerevisiae | YNL007C | Sis1p |
Schistosoma japonicum | Sjp_0050730 | DnaJ homolog subfamily B member 5, putative |
Schistosoma japonicum | Sjp_0094860 | ko:K09510 DnaJ homolog, subfamily B, member 4, putative |
Schistosoma japonicum | Sjp_0209050 | ko:K09519 DnaJ homolog, subfamily B, member 13, putative |
Schistosoma mansoni | Smp_020920.1 | DNAj homolog subfamily B member 4 |
Schistosoma mansoni | Smp_020920.2 | DNAj homolog subfamily B member 4 |
Schistosoma mansoni | Smp_104730 | DNAj homolog subfamily B member 4 |
Schmidtea mediterranea | mk4.000171.01 | Hsp40 |
Schmidtea mediterranea | mk4.002178.02 | DnaJ homolog subfamily B member 13 |
Schmidtea mediterranea | mk4.001362.08 | DnaJ homolog subfamily B member 13 |
Schmidtea mediterranea | mk4.001362.07 | |
Trypanosoma brucei gambiense | Tbg972.10.10330 | chaperone protein DNAj, putative |
Trypanosoma brucei | Tb927.10.8540 | chaperone protein DnaJ, putative |
Trypanosoma congolense | TcIL3000_10_7330 | chaperone protein DnaJ, putative |
Trypanosoma cruzi | TcCLB.506355.50 | chaperone DNAJ protein, putative |
Trypanosoma cruzi | TcCLB.511043.30 | DnaJ chaperone protein, putative |
Toxoplasma gondii | TGME49_265310 | heat shock protein 40, putative |
Theileria parva | TP02_0625 | dnaJ protein, putative |
Trichomonas vaginalis | TVAG_347420 | DNAj/HSP40, putative |
Trichomonas vaginalis | TVAG_317210 | DNAj/HSP40, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.8540 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.8540 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.8540 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.8540 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F54D5.8 | Caenorhabditis elegans | sterile | wormbase |
YNL007C | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0310000 | Plasmodium berghei | Dispensable | plasmo |
TGME49_265310 | Toxoplasma gondii | Essentiality uncertain | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Type | Source | Notes |
---|---|---|
soluble recombinant protein | Structural Genomics for Pathogenic Protozoa (SGPP) | Lmaj006170; Recombinant protein: full-length; Source: L major; chaperone protein DNAJ putative ; |