pI: 11.4334 |
Length (AA): 121 |
MW (Da): 14006 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
2 | 118 | 2qam (Q) | 1 | 117 | 60.00 | 0 | 1 | 1.59 | 0.69 |
20 | 118 | 2ghj (A) | 18 | 116 | 53.00 | 0 | 1 | 1.49 | -0.52 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128492)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | ArthCp045 | 50S ribosomal protein L20 |
Arabidopsis thaliana | AT1G16740 | ribosomal protein L20 |
Babesia bovis | BBOV_III005560 | ribosomal protein L20, putative |
Chlamydia trachomatis | CT_835 | 50S ribosomal protein L20 |
Dictyostelium discoideum | DDB_G0273295 | hypothetical protein |
Dictyostelium discoideum | DDB_G0273771 | hypothetical protein |
Drosophila melanogaster | Dmel_CG11258 | mitochondrial ribosomal protein L20 |
Escherichia coli | b1716 | 50S ribosomal subunit protein L20 |
Echinococcus granulosus | EgrG_000098900 | 50S ribosomal protein L20 |
Echinococcus multilocularis | EmuJ_000098900 | 50S ribosomal protein L20 |
Homo sapiens | ENSG00000242485 | mitochondrial ribosomal protein L20 |
Mycobacterium leprae | ML1396 | Probable 50S ribosomal protein L20 RplT |
Mus musculus | ENSMUSG00000029066 | mitochondrial ribosomal protein L20 |
Mycobacterium tuberculosis | Rv1643 | 50S ribosomal protein L20 RplT |
Mycobacterium ulcerans | MUL_1629 | 50S ribosomal protein L20 |
Neospora caninum | NCLIV_000250 | ribosomal protein L20, putative |
Oryza sativa | 3131425 | 50S ribosomal protein L20 |
Oryza sativa | 4324162 | Os01g0734100 |
Oryza sativa | 4339398 | Os05g0528200 |
Onchocerca volvulus | OVOC8531 |
|
Onchocerca volvulus | OVOC8538 |
|
Plasmodium berghei | PBANKA_1302100 | 50S ribosomal protein L20, putative |
Plasmodium falciparum | PF3D7_1474100 | mitochondrial ribosomal protein L20 precursor, putative |
Plasmodium knowlesi | PKNH_1244400 | ribosomal protein L20, putative |
Plasmodium vivax | PVX_118585 | 50S ribosomal protein L20, putative |
Plasmodium yoelii | PY02256 | ribosomal protein L20 |
Schistosoma japonicum | Sjp_0212900 | ko:K02887 large subunit ribosomal protein L20, putative |
Schistosoma mansoni | Smp_004980 | 50S ribosomal protein L20 |
Schmidtea mediterranea | mk4.039025.02 | |
Schmidtea mediterranea | mk4.002298.02 | 39S ribosomal protein L20, mitochondrial |
Toxoplasma gondii | TGME49_293310 | ribosomal protein L20, putative |
Treponema pallidum | TP0848 | 50S ribosomal protein L20 |
Theileria parva | TP02_0392 | 60S ribosomal protein L20, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0657 | 50S ribosomal protein L20 |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
b1716 | Escherichia coli | essential | goodall |
TGME49_293310 | Toxoplasma gondii | Probably essential | sidik |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.