Detailed view for Bm1_17680

Basic information

TDR Targets ID: 233566
Brugia malayi, enoyl-CoA hydratase/isomerase family protein
Source Database / ID:  GenBank

pI: 8.777 | Length (AA): 291 | MW (Da): 33425 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00378   Enoyl-CoA hydratase/isomerase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005488   binding  
GO:0003824   catalytic activity  
GO:0000062   acyl-CoA binding  
GO:0008152   metabolic process  

Metabolic Pathways

Fatty acid metabolism (KEGG)
Peroxisome (KEGG)

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
13 58 3flv (A) 6 88 30.00 0 0.96 -0.119324 -1.93
65 140 4k29 (A) 2 67 47.00 0.13 0.66 0.539768 0.37
80 282 4u19 (A) 107 348 43.00 0 1 0.978194 0.19
80 291 3pea (A) 5 252 23.00 0.000078 1 0.869122 -0.01
80 291 1ef8 (A) 6 255 25.00 0.32 1 0.885122 0.33
81 291 2fw2 (A) 5 257 31.00 0 1 0.857686 0.11
84 285 1hnu (A) 15 270 24.00 0 0.59 0.677758 0.59
85 286 3hrx (A) 7 243 32.00 0.000000000043 0.92 0.799758 0.86

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129422)

Species Accession Gene Product
Brugia malayi Bm1_17680   enoyl-CoA hydratase/isomerase family protein
Candida albicans CaO19.13801   one of two potential enoyl-CoA hydratase/isomerase genes similar to S. cerevisiae ECI1 (YLR284C) and DCI1 (YOR180C) peroxisomal
Candida albicans CaO19.13803   one of two potential enoyl-CoA hydratase/isomerase genes similar to S. cerevisiae ECI1 (YLR284C) and DCI1 (YOR180C) peroxisomal
Candida albicans CaO19.6445   one of two potential enoyl-CoA hydratase/isomerase genes similar to S. cerevisiae ECI1 (YLR284C) and DCI1 (YOR180C) peroxisomal
Candida albicans CaO19.6443   one of two potential enoyl-CoA hydratase/isomerase genes similar to S. cerevisiae ECI1 (YLR284C) and DCI1 (YOR180C) peroxisomal
Caenorhabditis elegans CELE_R06F6.9   Protein ECH-4
Drosophila melanogaster Dmel_CG13890   CG13890 gene product from transcript CG13890-RA
Echinococcus granulosus EgrG_000068800   enoyl coenzyme A hydratase
Echinococcus multilocularis EmuJ_000068800   enoyl coenzyme A hydratase
Homo sapiens ENSG00000198721   enoyl-CoA delta isomerase 2
Loa Loa (eye worm) LOAG_10599   hypothetical protein
Mus musculus ENSMUSG00000021416   enoyl-Coenzyme A delta isomerase 3
Mus musculus ENSMUSG00000021417   enoyl-Coenzyme A delta isomerase 2
Mycobacterium ulcerans MUL_0359   enoyl-CoA hydratase
Mycobacterium ulcerans MUL_2995   enoyl-CoA hydratase, EchA8_6
Saccharomyces cerevisiae YLR284C   dodecenoyl-CoA isomerase
Saccharomyces cerevisiae YOR180C   putative dodecenoyl-CoA isomerase DCI1
Schistosoma mansoni Smp_078280   enoyl-CoA hydratase-related
Schmidtea mediterranea mk4.002105.02   Enoyl-CoA delta isomerase 2, mitochondrial
Schmidtea mediterranea mk4.002805.04   Enoyl-CoA delta isomerase 2, mitochondrial
Schmidtea mediterranea mk4.008477.00   Enoyl-CoA hydratase-related

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_17680 (Brugia malayi), enoyl-CoA hydratase/isomerase family protein
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