Detailed view for Bm1_00375

Basic information

TDR Targets ID: 233569
Brugia malayi, Centromere/kinetochore Zw10 family protein
Source Database / ID:  GenBank

pI: 6.2425 | Length (AA): 1287 | MW (Da): 146443 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00009   Elongation factor Tu GTP binding domain
PF00679   Elongation factor G C-terminus
PF03764   Elongation factor G, domain IV
PF06248   Centromere/kinetochore Zw10
PF14492   Elongation Factor G, domain II

Gene Ontology

Mouse over links to read term descriptions.
GO:0000775   chromosome, pericentric region  
GO:0005634   nucleus  
GO:0003924   GTPase activity  
GO:0005525   GTP binding  
GO:0000278   mitotic cell cycle  
GO:0007067   mitosis  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 12 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 201 4tql (A) 23 228 14.00 0.0000029 0.71 0.346777 -0.85
9 749 5hdt (B) 348 1084 10.00 0 1 0.586158 0.6
13 277 4bt8 (A) 22 238 31.00 0.96 0.3 0.0239052 1.74
24 719 2x1g (F) 168 932 11.00 0 0.94 0.533193 0.74
25 671 1z3h (B) 92 784 14.00 0 1 0.51712 0.56
26 209 4uos (A) 1 184 14.00 0.0074 0.14 0.351568 -1.4
734 953 4kjz (A) 43 228 31.00 0.89 0.92 0.11894 0.96
734 953 4b3x (A) 43 228 31.00 0.000039 0.76 0.21194 1.07
772 1276 2xex (A) 2 684 37.00 0 1 0.215985 0.81
773 1274 4fn5 (A) 3 697 39.00 0 1 0.322054 0.7
776 1006 5ty0 (A) 4 244 46.00 0 1 0.485487 0.36
779 924 4ac9 (C) 4 135 30.00 0 0.99 0.388842 -0.36

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_178870)

Species Accession Gene Product
Brugia malayi Bm1_00375   Centromere/kinetochore Zw10 family protein
Loa Loa (eye worm) LOAG_03865   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_00375 (Brugia malayi), Centromere/kinetochore Zw10 family protein
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