Detailed view for LmjF.36.4880

Basic information

TDR Targets ID: 23373
Leishmania major, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.7438 | Length (AA): 239 | MW (Da): 25811 | Paralog Number: 2

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 7

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03083   Sugar efflux transporter for intercellular exchange

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 221 2b2h (A) 9 243 17.00 0.00000031 0.01 0.95 -0.43
4 219 5ctg (A) 8 214 21.00 0 0.14 1.02417 0.39
18 101 4z31 (A) 140 238 31.00 0.92 0.15 0.237464 2.29

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_127038)

Species Accession Gene Product
Arabidopsis thaliana AT4G15920   bidirectional sugar transporter SWEET17
Arabidopsis thaliana AT5G23660   bidirectional sugar transporter SWEET12
Arabidopsis thaliana AT5G50800   bidirectional sugar transporter SWEET13
Arabidopsis thaliana AT5G13170   senescence-associated protein 29
Arabidopsis thaliana AT1G66770   bidirectional sugar transporter SWEET6
Arabidopsis thaliana AT3G16690   bidirectional sugar transporter SWEET16
Arabidopsis thaliana AT3G48740   bidirectional sugar transporter SWEET11
Arabidopsis thaliana AT2G39060   bidirectional sugar transporter SWEET9
Arabidopsis thaliana AT4G10850   bidirectional sugar transporter SWEET7
Arabidopsis thaliana AT4G25010   bidirectional sugar transporter SWEET14
Babesia bovis BBOV_IV003820   Mtn3/RAG1IP-like protein, putative
Babesia bovis BBOV_IV003770   Mtn3/RAG1IP-like protein, putative
Brugia malayi Bm1_45805   MtN3/saliva family protein
Caenorhabditis elegans CELE_C54F6.4   Protein SWT-2
Caenorhabditis elegans CELE_K02D7.5   Protein SWT-1
Caenorhabditis elegans CELE_Y39A1A.8   Protein SWT-4
Dictyostelium discoideum DDB_G0286235   hypothetical protein
Dictyostelium discoideum DDB_G0287763   hypothetical protein
Dictyostelium discoideum DDB_G0287613   hypothetical protein
Dictyostelium discoideum DDB_G0283155   hypothetical protein
Drosophila melanogaster Dmel_CG8717   saliva
Homo sapiens ENSG00000169241   solute carrier family 50 (sugar efflux transporter), member 1
Leishmania braziliensis LbrM.28.0360   hypothetical protein, unknown function
Leishmania braziliensis LbrM.35.5120   hypothetical protein, conserved
Leishmania donovani LdBPK_280490.1   Sugar efflux transporter for intercellular exchange, putative
Leishmania donovani LdBPK_365100.1   Sugar efflux transporter for intercellular exchange, putative
Leishmania infantum LinJ.28.0490   hypothetical protein, unknown function
Leishmania infantum LinJ.36.5100   hypothetical protein, conserved
Leishmania major LmjF.28.0350   hypothetical protein, unknown function
Leishmania major LmjF.36.4880   hypothetical protein, conserved
Leishmania major LmjF.36.4870   hypothetical protein, conserved
Leishmania mexicana LmxM.28.0350   hypothetical protein, unknown function
Leishmania mexicana LmxM.36.4870   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_09148   hypothetical protein
Loa Loa (eye worm) LOAG_08618   MtN3/saliva family protein
Mus musculus ENSMUSG00000027953   solute carrier family 50 (sugar transporter), member 1
Neospora caninum NCLIV_060430   Os08g0535200 protein, related
Oryza sativa 4324214   Os01g0606000
Oryza sativa 4350572   Os11g0508600
Oryza sativa 4329464   Os02g0513100
Oryza sativa 4329093   Os02g0301100
Oryza sativa 4332825   Os03g0347500
Oryza sativa 4352201   Os12g0476200
Oryza sativa 4324213   Os01g0605700
Oryza sativa 4339772   Os05g0588500
Oryza sativa 4346153   Os08g0535200
Plasmodium berghei PBANKA_0313300   MtN3-like protein
Plasmodium falciparum PF3D7_0216600   MtN3-like protein
Plasmodium knowlesi PKNH_0404300   MtN3/saliva family, putative
Plasmodium vivax PVX_002710   hypothetical protein, conserved
Plasmodium yoelii PY01249   MtN3/saliva family, putative
Trypanosoma cruzi TcCLB.511629.40   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.510493.10   hypothetical protein, conserved
Toxoplasma gondii TGME49_300250   MtN3/saliva family protein
Theileria parva TP01_1013   MtN3/RAG1IP protein, putative

Essentiality

LmjF.36.4880 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_0313300 Plasmodium berghei Dispensable plasmo
TGME49_300250 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.36.4880 (Leishmania major), hypothetical protein, conserved
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