Detailed view for Bm1_01565

Basic information

TDR Targets ID: 233810
Brugia malayi, Mitochondrial carrier protein
Source Database / ID:  GenBank

pI: 9.1326 | Length (AA): 305 | MW (Da): 33848 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00153   Mitochondrial carrier protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005743   mitochondrial inner membrane  
GO:0005488   binding  
GO:0055085   transmembrane transport  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128038)

Species Accession Gene Product
Arabidopsis thaliana AT2G30160   mitochondrial substrate carrier family protein
Arabidopsis thaliana AT1G07030   mitochondrial substrate carrier family protein
Babesia bovis BBOV_II006420   Mitochondrial carrier protein, putative
Brugia malayi Bm1_01565   Mitochondrial carrier protein
Candida albicans CaO19.2178   likely mitochondrial carrier protein similar to S. cerevisiae MRS3 (YJL133W) and MRS4 (YKR052C) mitochondrial iron transporters
Candida albicans CaO19.9724   likely mitochondrial carrier protein similar to S. cerevisiae MRS3 (YJL133W) and MRS4 (YKR052C) mitochondrial iron transporters
Caenorhabditis elegans CELE_W02B12.9   Protein MFN-1
Cryptosporidium hominis Chro.20115   mitochondrial carrier protein
Cryptosporidium parvum cgd2_1030   mitochondrial carrier protein, putative
Dictyostelium discoideum DDB_G0269470   mitochondrial substrate carrier family protein
Drosophila melanogaster Dmel_CG4963   mitoferrin
Echinococcus granulosus EgrG_000793300   mitoferrin 1
Echinococcus multilocularis EmuJ_000793300   mitoferrin 1
Homo sapiens 51312   solute carrier family 25 (mitochondrial iron transporter), member 37
Homo sapiens ENSG00000155287   solute carrier family 25 (mitochondrial iron transporter), member 28
Leishmania braziliensis LbrM.29.2840   mitochondrial carrier protein-like protein
Leishmania donovani LdBPK_292890.1   mitochondrial carrier protein-like protein
Leishmania infantum LinJ.29.2890   mitochondrial carrier protein-like protein
Leishmania major LmjF.29.2780   mitochondrial carrier protein-like protein
Leishmania mexicana LmxM.08_29.2780   mitochondrial carrier protein-like protein
Mus musculus ENSMUSG00000034248   solute carrier family 25, member 37
Mus musculus ensembl-mmu:ENSMUSG00000040414   solute carrier family 25, member 28
Neospora caninum NCLIV_068510   hypothetical protein
Oryza sativa 4332542   Os03g0296800
Saccharomyces cerevisiae YJL133W   Mrs3p
Saccharomyces cerevisiae YKR052C   Mrs4p
Schistosoma japonicum Sjp_0061630   ko:K03454 mitochondrial carrier protein, MC family, putative
Schistosoma mansoni Smp_055190   mitochondrial solute carrier-related
Schmidtea mediterranea mk4.000610.00   Mitoferrin
Schmidtea mediterranea mk4.000610.02   Mitoferrin
Schmidtea mediterranea mk4.010564.01   Mitoferrin
Schmidtea mediterranea mk4.054699.00   Mitoferrin
Trypanosoma brucei gambiense Tbg972.3.3060   mitochondrial carrier protein, putative
Trypanosoma brucei Tb927.3.2980   mitochondrial carrier protein
Trypanosoma congolense TcIL3000_3_1890   mitochondrial carrier protein, putative
Trypanosoma cruzi TcCLB.510315.20   mitochondrial carrier protein, putative
Trypanosoma cruzi TcCLB.508153.630   mitochondrial carrier protein, putative
Toxoplasma gondii TGME49_277090   carrier superfamily protein
Theileria parva TP02_0605   mitochondrial solute carrier protein, putative

Essentiality

Bm1_01565 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.2980 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.2980 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.3.2980 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.3.2980 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_W02B12.9 Caenorhabditis elegans embryonic lethal wormbase
CELE_W02B12.9 Caenorhabditis elegans slow growth wormbase
TGME49_277090 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_01565 (Brugia malayi), Mitochondrial carrier protein
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