Detailed view for Bm1_36200

Basic information

TDR Targets ID: 234038
Brugia malayi, Prefoldin subunit family protein
Source Database / ID:  GenBank

pI: 5.7655 | Length (AA): 181 | MW (Da): 21118 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02996   Prefoldin subunit

Gene Ontology

Mouse over links to read term descriptions.
GO:0016272   prefoldin complex  
GO:0051082   unfolded protein binding  
GO:0006457   protein folding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
23 153 4uos (A) 3 131 25.00 0.74 0.79 1.02086 -0.87
36 159 4uos (A) 1 137 21.00 0.12 0.5 0.909383 -1

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128207)

Species Accession Gene Product
Arabidopsis thaliana AT5G49510   putative prefoldin subunit 3
Babesia bovis BBOV_IV008490   prefoldin subunit, putative
Brugia malayi Bm1_36200   Prefoldin subunit family protein
Candida albicans CaO19.13406   similar to S. cerevisiae PAC10 (YGR078C) component of non-native actin binding complex (NABC)
Candida albicans CaO19.5985   similar to S. cerevisiae PAC10 (YGR078C) component of non-native actin binding complex (NABC)
Caenorhabditis elegans CELE_T06G6.9   Protein PFD-3
Cryptosporidium hominis Chro.50294   hypothetical protein
Cryptosporidium parvum cgd5_930   hypothetical protein
Dictyostelium discoideum DDB_G0286473   prefoldin alpha-like domain containing protein
Drosophila melanogaster Dmel_CG6719   merry-go-round
Echinococcus granulosus EgrG_000879800   prefoldin subunit 3
Entamoeba histolytica EHI_081270   Prefoldin subunit 3, putative
Echinococcus multilocularis EmuJ_000879800   prefoldin subunit 3
Giardia lamblia GL50803_7030   Prefoldin subunit 3, putative
Homo sapiens ENSG00000155959   von Hippel-Lindau binding protein 1
Leishmania braziliensis LbrM.26.1400   prefoldin-like protein
Leishmania donovani LdBPK_261360.1   prefoldin-like protein
Leishmania infantum LinJ.26.1360   prefoldin-like protein
Leishmania major LmjF.26.1380   prefoldin-like protein
Leishmania mexicana LmxM.26.1380   prefoldin-like protein
Loa Loa (eye worm) LOAG_09557   prefoldin subunit family protein
Loa Loa (eye worm) LOAG_01132   hypothetical protein
Mus musculus ENSMUSG00000031197   von Hippel-Lindau binding protein 1
Neospora caninum NCLIV_029610   prefoldin subunit 3, putative
Oryza sativa 4352529   Os12g0562900
Plasmodium berghei PBANKA_0616100   prefoldin subunit 3, putative
Plasmodium falciparum PF3D7_0718500   prefoldin subunit 3, putative
Plasmodium knowlesi PKNH_0313800   prefoldin subunit 3, putative
Plasmodium vivax PVX_096400   prefoldin subunit 3, putative
Plasmodium yoelii PY05270   hypothetical protein
Saccharomyces cerevisiae YGR078C   Pac10p
Schistosoma japonicum Sjp_0075310   Prefoldin subunit 3, putative
Schistosoma mansoni Smp_021800   prefoldin subunit 3-related
Schmidtea mediterranea mk4.003435.00   Probable prefoldin subunit 3
Trypanosoma brucei gambiense Tbg972.7.450   prefoldin, putative
Trypanosoma brucei Tb927.7.570   prefoldin, putative
Trypanosoma congolense TcIL3000_7_260   prefoldin, putative
Trypanosoma cruzi TcCLB.508881.120   prefoldin, putative
Trypanosoma cruzi TcCLB.506287.140   prefoldin, putative
Toxoplasma gondii TGME49_257490   prefoldin subunit superfamily protein
Theileria parva TP01_0927   prefoldin subunit 3, putative
Trichomonas vaginalis TVAG_000750   prefoldin subunit, putative

Essentiality

Bm1_36200 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.570 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.570 Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb927.7.570 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.570 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_T06G6.9 Caenorhabditis elegans embryonic lethal wormbase
PBANKA_0616100 Plasmodium berghei Slow plasmo
TGME49_257490 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Bm1_36200 (Brugia malayi), Prefoldin subunit family protein
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