Detailed view for Bm1_49675

Basic information

TDR Targets ID: 234719
Brugia malayi, SacI homology domain containing protein
Source Database / ID:  GenBank

pI: 7.9039 | Length (AA): 865 | MW (Da): 99309 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02383   SacI homology domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0042578   phosphoric ester hydrolase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
17 130 3bnv (A) 16 140 28.00 0.87 0.14 0.203692 1.22
51 529 3lwt (X) 23 455 27.00 0 1 0.663857 0.7
278 373 1zee (A) 273 376 34.00 0.59 0.28 0.194883 0.74

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128217)

Species Accession Gene Product
Arabidopsis thaliana AT3G43220   phosphoinositide phosphatase family protein
Arabidopsis thaliana AT1G22620   phosphoinositide phosphatase SAC1
Arabidopsis thaliana AT5G20840   phosphoinositide phosphatase family protein
Arabidopsis thaliana AT3G14205   phosphoinositide phosphatase family protein
Arabidopsis thaliana AT1G17340   protein SUPPRESSOR OF ACTIN 5
Babesia bovis BBOV_IV008690   Sac domain-containing inositol phosphatase 3, putative
Brugia malayi Bm1_49675   SacI homology domain containing protein
Candida albicans CaO19.13033   pheromone-induced protein, suppressor of sac1 mutation
Candida albicans CaO19.5586   pheromone-induced protein, suppressor of sac1 mutation
Caenorhabditis elegans CELE_C34B7.2   Protein C34B7.2
Dictyostelium discoideum DDB_G0281427   hypothetical protein
Drosophila melanogaster Dmel_CG17840   CG17840 gene product from transcript CG17840-RA
Echinococcus granulosus EgrG_000445900   polyphosphoinositide phosphatase
Echinococcus multilocularis EmuJ_000445900   polyphosphoinositide phosphatase
Homo sapiens ENSG00000112367   FIG4 phosphoinositide 5-phosphatase
Leishmania braziliensis LbrM.24.0840   inositol polyphosphate phosphatase, putative
Leishmania donovani LdBPK_240840.1   inositol polyphosphate phosphatase, putative
Leishmania infantum LinJ.24.0840   inositol polyphosphate phosphatase, putative
Leishmania major LmjF.24.0820   inositol polyphosphate phosphatase, putative
Leishmania mexicana LmxM.24.0820   inositol polyphosphate phosphatase, putative
Loa Loa (eye worm) LOAG_07724   hypothetical protein
Loa Loa (eye worm) LOAG_09316   hypothetical protein
Mus musculus ENSMUSG00000038417   FIG4 homolog (S. cerevisiae)
Oryza sativa 4344468   Os08g0109100
Oryza sativa 4340387   Os06g0195600
Oryza sativa 9272078   Os06g0355150
Oryza sativa 9270014   Os07g0421200
Oryza sativa 4331839   Os03g0182400
Onchocerca volvulus OVOC718   Polyphosphoinositide phosphatase homolog
Plasmodium berghei PBANKA_1227700   inositol 5-phosphatase, putative
Plasmodium falciparum PF3D7_0802500   inositol 5-phosphatase, putative
Plasmodium knowlesi PKNH_0116400   inositol 5-phosphatase, putative
Plasmodium vivax PVX_093615   inositol 5-phosphatase, putative
Plasmodium yoelii PY04281   Homo sapiens KIAA0851 protein, putative
Saccharomyces cerevisiae YNL325C   phosphatidylinositol-3,5-bisphosphate 5-phosphatase
Schistosoma japonicum Sjp_0003180   similar to Uncharacterized protein C1093.03, putative
Schistosoma japonicum Sjp_0110540   similar to Uncharacterized protein C1093.03, putative
Schistosoma japonicum Sjp_0003190   Polyphosphoinositide phosphatase, putative
Schistosoma japonicum Sjp_0123410   similar to Uncharacterized protein C1093.03, putative
Schistosoma mansoni Smp_157920   suppressor of actin (sac)-related
Schmidtea mediterranea mk4.009085.01   Polyphosphoinositide phosphatase
Schmidtea mediterranea mk4.021165.01   Polyphosphoinositide phosphatase
Schmidtea mediterranea mk4.021165.00   Polyphosphoinositide phosphatase
Trypanosoma brucei gambiense Tbg972.11.6200   synaptojanin (N-terminal domain), putative
Trypanosoma brucei Tb927.11.5490   Polyphosphoinositide phosphatase, putative
Trypanosoma congolense TcIL3000.11.5770   synaptojanin (N-terminal domain), putative
Theileria parva TP01_0904   hypothetical protein

Essentiality

Bm1_49675 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.02.3170 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.02.3170 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.02.3170 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.02.3170 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
PBANKA_1227700 Plasmodium berghei Slow plasmo
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Bm1_49675 (Brugia malayi), SacI homology domain containing protein
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