Detailed view for Bm1_20605

Basic information

TDR Targets ID: 234758
Brugia malayi, 26S proteasome regulatory subunit rpn11
Source Database / ID:  GenBank

pI: 6.1725 | Length (AA): 314 | MW (Da): 34980 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01398   JAB1/Mov34/MPN/PAD-1 ubiquitin protease
PF13012   Maintenance of mitochondrial structure and function

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

Proteasome (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
14 309 4d10 (E) 35 332 29.00 0 1 1.25838 0.08
31 186 2o96 (A) 5 163 25.00 0 1 0.776315 -0.74
33 227 4o8y (B) 25 219 84.00 0 1 1.41852 -0.43

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127757)

Species Accession Gene Product
Arabidopsis thaliana AT5G23540   26S proteasome non-ATPase regulatory subunit 14
Babesia bovis BBOV_II007480   26S proteasome regulatory subunit, putative
Brugia malayi Bm1_20605   26S proteasome regulatory subunit rpn11
Brugia malayi Bm1_21270   Hypothetical 35.8 kDa protein F37A4.5 in chromosome III
Candida albicans CaO19.7264   similar to S. cerevisiae RPN11 (YFR004W) deubiquitinylating metalloisopeptidase subunit of the 19S regulatory particle of the 26
Caenorhabditis elegans CELE_K07D4.3   Protein RPN-11
Cryptosporidium hominis Chro.60380   Mov34/MPN/PAD-1 family proteasome regulatory subunit
Cryptosporidium parvum cgd6_3270   26S proteasome-associated Mov34/MPN/PAD-1 family. JAB domain.
Dictyostelium discoideum DDB_G0272566   26S proteasome non-ATPase regulatory subunit 14
Drosophila melanogaster Dmel_CG18174   Regulatory particle non-ATPase 11
Echinococcus granulosus EgrG_000795700   26S proteasome regulatory subunit N11
Echinococcus granulosus EgrG_001166800   26S proteasome regulatory subunit N11
Entamoeba histolytica EHI_164750   26S proteasome non-ATPase regulatory subunit 14, putative
Echinococcus multilocularis EmuJ_000795700   26S proteasome regulatory subunit N11
Echinococcus multilocularis EmuJ_001166800   26S proteasome regulatory subunit N11
Giardia lamblia GL50803_16823   Non ATPase subunit MPR1 of 26S proteasome
Homo sapiens ENSG00000115233   proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
Leishmania braziliensis LbrM.20.0580   proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6
Leishmania donovani LdBPK_340670.1   proteasome regulatory non-ATPase subunit 11, putative
Leishmania infantum LinJ.34.0670   proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6
Leishmania major LmjF.34.0650   proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6
Leishmania mexicana LmxM.33.0650   proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6
Loa Loa (eye worm) LOAG_06303   26S proteasome regulatory subunit rpn11
Loa Loa (eye worm) LOAG_06974   proteasome 26S subunit
Mus musculus ENSMUSG00000026914   proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
Neospora caninum NCLIV_036720   CBR-CSN-5 protein, related
Oryza sativa 4338586   Os05g0371200
Oryza sativa 4324379   Os01g0267200
Plasmodium berghei PBANKA_1144000   26S proteasome regulatory subunit RPN11, putative
Plasmodium falciparum PF3D7_1368100   26S proteasome regulatory subunit RPN11, putative
Plasmodium knowlesi PKNH_1103100   26S proteasome regulatory subunit RPN11, putative
Plasmodium vivax PVX_115365   26S proteasome regulatory subunit RPN11, putative
Plasmodium yoelii PY03078   Mov34/MPN/PAD-1 family, putative
Saccharomyces cerevisiae YFR004W   proteasome regulatory particle lid subunit RPN11
Schistosoma japonicum Sjp_0203370   ko:K03030 26S proteasome regulatory subunit N11, putative
Schmidtea mediterranea mk4.002259.02   26S proteasome non-ATPase regulatory subunit 14
Trypanosoma brucei gambiense Tbg972.10.3730   proteasome regulatory non-ATPase subunit 11,19S proteasome regulatory subunit, Metallo-peptidase, Clan MP, Family M67, putative
Trypanosoma brucei gambiense Tbg972.10.3790   proteasome regulatory non-ATPase subunit 11,19S proteasome regulatory subunit, Metallo-peptidase, Clan MP, Family M67
Trypanosoma brucei Tb927.10.2980   proteasome regulatory non-ATPase subunit 11
Trypanosoma brucei Tb927.10.3030   proteasome regulatory non-ATPase subunit 11
Trypanosoma cruzi TcCLB.509627.30   proteasome regulatory non-ATPase subunit 11, putative
Toxoplasma gondii TGME49_269840   proteasome regulatory subunit
Theileria parva TP02_0201   proteasome regulatory subunit, putative
Trichomonas vaginalis TVAG_077600   Clan MP, family M67, Poh1-like metallopeptidase
Trichomonas vaginalis TVAG_159580   Clan MP, family M67, Poh1-like metallopeptidase
Trichomonas vaginalis TVAG_469140   Clan MP, family M67, Poh1-like metallopeptidase

Essentiality

Bm1_20605 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.2980 Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb927.10.2980 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.2980 Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb927.10.2980 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_K07D4.3 Caenorhabditis elegans adult lethal wormbase
CELE_K07D4.3 Caenorhabditis elegans embryonic lethal wormbase
CELE_K07D4.3 Caenorhabditis elegans larval arrest wormbase
CELE_K07D4.3 Caenorhabditis elegans larval lethal wormbase
CELE_K07D4.3 Caenorhabditis elegans slow growth wormbase
YFR004W Saccharomyces cerevisiae inviable yeastgenome
TGME49_269840 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0026 0.3953 0.3953

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_20605 (Brugia malayi), 26S proteasome regulatory subunit rpn11
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