Detailed view for Bm1_17460

Basic information

TDR Targets ID: 234886
Brugia malayi, TBC domain containing protein
Source Database / ID:  GenBank

pI: 6.6008 | Length (AA): 437 | MW (Da): 50103 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00566   Rab-GTPase-TBC domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0005097   Rab GTPase activator activity  
GO:0032313   regulation of Rab GTPase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
8 330 4nc6 (A) 556 828 24.00 0.16 1 0.91193 -0.4
8 320 2qq8 (A) 376 664 49.00 0.0023 1 1.19705 -0.88
196 304 3qwl (A) 176 284 22.00 0.025 0.93 0.697928 -1.42

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130069)

Species Accession Gene Product
Brugia malayi Bm1_17460   TBC domain containing protein
Caenorhabditis elegans CELE_R11B5.1   Protein TBC-12
Dictyostelium discoideum DDB_G0280955   RabGAP/TBC domain-containing protein
Dictyostelium discoideum DDB_G0269130   RabGAP/TBC domain-containing protein
Echinococcus granulosus EgrG_000728200   TBC1 domain family 2
Echinococcus multilocularis EmuJ_000728200   TBC1 domain family 2
Homo sapiens ENSG00000108239   TBC1 domain family, member 12
Homo sapiens ENSG00000132405   TBC1 domain family, member 14
Loa Loa (eye worm) LOAG_06383   hypothetical protein
Mus musculus ENSMUSG00000029192   TBC1 domain family, member 14
Mus musculus ENSMUSG00000048720   TBC1D12: TBC1 domain family, member 12
Mus musculus 102641289   TBC1 domain family member 14-like
Neospora caninum NCLIV_009350   hypothetical protein
Schistosoma japonicum Sjp_0213380   TBC1 domain family member 12, putative
Schistosoma mansoni Smp_079800   GTPase activating protein
Schmidtea mediterranea mk4.015925.01  
Schmidtea mediterranea mk4.017099.00  
Trypanosoma cruzi TcCLB.506727.10   hypothetical protein
Trypanosoma cruzi TcCLB.511529.250   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_17460 (Brugia malayi), TBC domain containing protein
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