Detailed view for LmjF.34.1720

Basic information

TDR Targets ID: 23490
Leishmania major, amastin-like surface protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.0116 | Length (AA): 192 | MW (Da): 21403 | Paralog Number: 23

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 4

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF07344   Amastin surface glycoprotein

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
64 160 3x29 (A) 51 169 30.00 0.48 0.07 0.347208 2.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 0-20% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_130729)

Species Accession Gene Product
Leishmania braziliensis LbrM.20.4320   amastin-like surface protein, putative
Leishmania braziliensis LbrM.20.1080   amastin-like surface protein, putative
Leishmania braziliensis LbrM.13.1330   amastin
Leishmania braziliensis LbrM.20.1060   amastin-like surface protein, putative
Leishmania braziliensis LbrM.20.4340   amastin-like surface protein, putative
Leishmania braziliensis LbrM.20.1070   amastin-like surface protein, putative
Leishmania braziliensis LbrM.18.0470   amastin-like surface protein
Leishmania braziliensis LbrM.20.2370   amastin-like surface protein, putative
Leishmania braziliensis LbrM.20.2390   amastin-like surface protein, putative
Leishmania braziliensis LbrM.20.1480   amastin-like surface protein, putative
Leishmania braziliensis LbrM.08.0670   amastin-like protein
Leishmania braziliensis LbrM.20.2410   amastin-like surface protein, putative
Leishmania braziliensis LbrM.20.4310   amastin-like surface protein, putative
Leishmania donovani LdBPK_341150.1   amastin-like surface protein, putative
Leishmania donovani LdBPK_341700.1   amastin-like surface protein, putative
Leishmania infantum LinJ.34.1710   amastin-like surface protein, putative
Leishmania infantum LinJ.34.1150   amastin-like surface protein, putative
Leishmania infantum LinJ.34.1700   amastin-like surface protein, putative
Leishmania major LmjF.34.1860   amastin-like surface protein, putative
Leishmania major LmjF.34.1960   amastin-like surface protein, putative
Leishmania major LmjF.34.1780   amastin-like surface protein, putative
Leishmania major LmjF.34.1640   amastin-like surface protein, putative
Leishmania major LmjF.34.1900   amastin-like surface protein, putative
Leishmania major LmjF.34.1680   amastin-like surface protein, putative
Leishmania major LmjF.34.1760   amastin-like surface protein, putative
Leishmania major LmjF.34.1080   amastin-like surface protein, putative
Leishmania major LmjF.34.1940   amastin-like surface protein, putative
Leishmania major LmjF.34.1740   amastin-like surface protein, putative
Leishmania major LmjF.34.1800   amastin-like surface protein, putative
Leishmania major LmjF.34.1600   amastin-like surface protein, putative
Leishmania major LmjF.34.1700   amastin-like surface protein, putative
Leishmania major LmjF.34.1980   amastin-like surface protein, putative
Leishmania major LmjF.34.0960   amastin-like surface protein, putative
Leishmania major LmjF.34.1660   amastin-like surface protein, putative
Leishmania major LmjF.34.1580   amastin-like surface protein, putative
Leishmania major LmjF.34.1880   amastin-like surface protein, putative
Leishmania major LmjF.34.1720   amastin-like surface protein, putative
Leishmania major LmjF.34.1560   amastin-like surface protein, putative
Leishmania major LmjF.34.1820   amastin-like surface protein, putative
Leishmania major LmjF.36.1270   amastin-like surface protein-like protein
Leishmania major LmjF.34.1920   amastin-like surface protein, putative
Leishmania major LmjF.34.1620   amastin-like surface protein, putative
Leishmania mexicana LmxM.33.1720c  
Leishmania mexicana LmxM.33.1820  
Leishmania mexicana LmxM.33.1800  
Leishmania mexicana LmxM.33.1721  
Leishmania mexicana LmxM.33.1920c  
Leishmania mexicana LmxM.33.1920d  
Leishmania mexicana LmxM.33.1920e  
Leishmania mexicana LmxM.33.1680  
Leishmania mexicana LmxM.33.1560   amastin-like surface protein, putative
Leishmania mexicana LmxM.33.1920  
Leishmania mexicana LmxM.33.1920b  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.34.1720 (Leishmania major), amastin-like surface protein, putative
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