Detailed view for Bm1_57300

Basic information

TDR Targets ID: 234921
Brugia malayi, CG14616-PC
Source Database / ID:  GenBank

pI: 6.9642 | Length (AA): 1021 | MW (Da): 116624 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00328   Histidine phosphatase superfamily (branch 2)

Gene Ontology

Mouse over links to read term descriptions.
GO:0000829   inositol heptakisphosphate kinase activity  
GO:0003993   acid phosphatase activity  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 306 3t7a (A) 51 360 67.00 0 1 1.09371 -0.52
550 771 4tql (A) 19 231 16.00 0.00096 0.51 0.413134 -0.55

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127768)

Species Accession Gene Product
Arabidopsis thaliana AT3G01310   phosphoglycerate mutase-like protein
Arabidopsis thaliana AT5G15070   phosphoglycerate mutase-like protein
Babesia bovis BBOV_IV010350   histidine acid phosphatase superfamily protein
Brugia malayi Bm1_57300   CG14616-PC
Candida albicans CaO19.8595   C terminus of S. pombe asp1-like orf, important for the function of the cortical actin cytoskeleton.
Candida albicans CaO19.980   C terminus of S. pombe asp1-like orf, important for the function of the cortical actin cytoskeleton.
Candida albicans CaO19.5679   N terminus of S. pombe asp1-like orf, important for the function of the cortical actin cytoskeleton.
Caenorhabditis elegans CELE_F46F11.1   Protein F46F11.1, isoform A
Cryptosporidium hominis Chro.70177   hypothetical protein
Cryptosporidium parvum cgd7_1500   conserved protein
Dictyostelium discoideum DDB_G0284617   hypothetical protein
Drosophila melanogaster Dmel_CG14616   lethal (1) G0196
Echinococcus granulosus EgrG_000064700   inositol hexakisphosphate
Echinococcus multilocularis EmuJ_000064700   inositol hexakisphosphate
Giardia lamblia GL50803_103074   Hypothetical protein
Homo sapiens ENSG00000168781   diphosphoinositol pentakisphosphate kinase 1
Homo sapiens 100508782   inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1-like
Homo sapiens ENSG00000145725   diphosphoinositol pentakisphosphate kinase 2
Loa Loa (eye worm) LOAG_01583   hypothetical protein
Mus musculus ENSMUSG00000033526   diphosphoinositol pentakisphosphate kinase 1
Mus musculus ENSMUSG00000040648   diphosphoinositol pentakisphosphate kinase 2
Neospora caninum NCLIV_019880   GH24076, related
Oryza sativa 4333768   Os03g0689100
Oryza sativa 4327902   Os01g0777700
Plasmodium berghei PBANKA_1014400   acid phosphatase, putative
Plasmodium falciparum PF3D7_1430300   acid phosphatase, putative
Plasmodium knowlesi PKNH_1328400   acid phosphatase, putative
Plasmodium vivax PVX_085025   hypothetical protein, conserved
Plasmodium yoelii PY01267   unknown protein-related
Saccharomyces cerevisiae YLR410W   inositol polyphosphate kinase VIP1
Schistosoma japonicum Sjp_0219600   expressed protein
Schistosoma japonicum Sjp_0041140   Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase, putative
Schistosoma japonicum Sjp_0313570   IPR001451,Bacterial transferase hexapeptide repeat;IPR011004,Trimeric LpxA-like,domain-containing
Schistosoma japonicum Sjp_0041130   Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2, putative
Schistosoma mansoni Smp_045860.2   histidine acid phosphatase
Schistosoma mansoni Smp_045860.1   histidine acid phosphatase
Schmidtea mediterranea mk4.002166.01   Putative histidine acid phosphatase
Schmidtea mediterranea mk4.004917.02   Putative histidine acid phosphatase
Toxoplasma gondii TGME49_304650   histidine acid phosphatase superfamily protein
Theileria parva TP01_0694   hypothetical protein, conserved

Essentiality

Bm1_57300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1014400 Plasmodium berghei Dispensable plasmo
TGME49_304650 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_57300 (Brugia malayi), CG14616-PC
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