Detailed view for Bm1_03840

Basic information

TDR Targets ID: 235078
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 10.9381 | Length (AA): 152 | MW (Da): 17734 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03879   Cgr1 family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 149 4uos (A) 47 184 17.00 0 0.03 1.13133 -1.05
75 149 4gnk (E) 1075 1156 20.00 0 0.06 0.799121 -1.52
76 142 5hmo (A) 844 908 32.00 0.42 0 0.817489 -1.02
87 151 5j0k (A) 6 73 22.00 0.67 0.01 0.722932 -1.48

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129520)

Species Accession Gene Product
Arabidopsis thaliana AT2G31410   hypothetical protein
Babesia bovis BBOV_IV000280   conserved hypothetical protein
Brugia malayi Bm1_03840   hypothetical protein
Caenorhabditis elegans CELE_Y40B1B.7   Protein Y40B1B.7
Cryptosporidium hominis Chro.70169   hypothetical protein
Cryptosporidium parvum cgd7_1420   hypothetical protein
Dictyostelium discoideum DDB_G0268762   hypothetical protein
Drosophila melanogaster Dmel_CG14210   CG14210 gene product from transcript CG14210-RA
Echinococcus granulosus EgrG_000779800   coiled coil domain containing protein 86
Entamoeba histolytica EHI_184520   hypothetical protein
Echinococcus multilocularis EmuJ_000779800   coiled coil domain containing protein 86
Giardia lamblia GL50803_20603   Hypothetical protein
Homo sapiens ENSG00000110104   coiled-coil domain containing 86
Leishmania braziliensis LbrM.34.4620   hypothetical protein, conserved
Leishmania donovani LdBPK_354710.1   hypothetical protein, conserved
Leishmania infantum LinJ.35.4710   hypothetical protein, conserved
Leishmania major LmjF.35.4640   hypothetical protein, conserved
Leishmania mexicana LmxM.34.4640   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_04573   hypothetical protein
Mus musculus ENSMUSG00000024732   coiled-coil domain containing 86
Neospora caninum NCLIV_048980   hypothetical protein, conserved
Oryza sativa 4329857   Os02g0595400
Onchocerca volvulus OVOC11933  
Schistosoma japonicum Sjp_0203670   Conserved hypothetical protein
Schistosoma mansoni Smp_052500   hypothetical protein
Trypanosoma brucei gambiense Tbg972.9.5770   hypothetical protein, conserved
Trypanosoma brucei Tb927.9.10000   hypothetical protein, conserved
Trypanosoma congolense TcIL3000_9_3670   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.510731.68   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.506887.80   hypothetical protein, conserved
Toxoplasma gondii TGME49_223490   hypothetical protein
Theileria parva TP02_0932   hypothetical protein

Essentiality

Bm1_03840 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb09.211.1540 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb09.211.1540 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb09.211.1540 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb09.211.1540 Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_Y40B1B.7 Caenorhabditis elegans embryonic lethal wormbase
CELE_Y40B1B.7 Caenorhabditis elegans slow growth wormbase
TGME49_223490 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_03840 (Brugia malayi), hypothetical protein
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