Detailed view for Bm1_12820

Basic information

TDR Targets ID: 235159
Brugia malayi, Protein kinase domain containing protein
Source Database / ID:  GenBank

pI: 9.9434 | Length (AA): 375 | MW (Da): 42752 | Paralog Number: 3

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00069   Protein kinase domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004713   protein tyrosine kinase activity  
GO:0004674   protein serine/threonine kinase activity  
GO:0004672   protein kinase activity  
GO:0006468   protein amino acid phosphorylation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 351 2rsv (A) 11 396 21.00 0 1 1.0064 0.73
16 305 4nfn (A) 24 312 38.00 0 1 1.26373 -0.59
21 306 1csn (A) 7 298 27.00 0 1 1.10107 -0.37
104 171 5dbx (A) 169 226 41.00 0.0073 0.46 0.373933 0.73

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_143236)

Species Accession Gene Product
Brugia malayi Bm1_50815   hypothetical protein
Brugia malayi Bm1_12715   hypothetical protein
Brugia malayi Bm1_12820   Protein kinase domain containing protein
Brugia malayi Bm1_57115   hypothetical protein
Caenorhabditis elegans CELE_R03G8.1   Protein R03G8.1
Caenorhabditis elegans CELE_F54H5.2   Protein F54H5.2
Caenorhabditis elegans CELE_K03A11.4   Protein K03A11.4
Caenorhabditis elegans CELE_C56C10.6   Protein C56C10.6
Caenorhabditis elegans CELE_R03G8.3   Protein R03G8.3
Caenorhabditis elegans CELE_Y73F8A.35   Protein Y73F8A.35, isoform A
Loa Loa (eye worm) LOAG_02772   hypothetical protein
Loa Loa (eye worm) LOAG_06430   CK1/TTBKL protein kinase
Loa Loa (eye worm) LOAG_01888   CK1/TTBKL protein kinase
Loa Loa (eye worm) LOAG_07878   hypothetical protein
Onchocerca volvulus OVOC11905  
Onchocerca volvulus OVOC7038  
Onchocerca volvulus OVOC7724  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Casein kinase I isoform alpha 325 aa 28.1% 303 aa Compounds References
Plasmodium falciparum (isolate 3D7) Cell division control protein 2 homolog 288 aa 24.9% 273 aa Compounds References
Sus scrofa Casein kinase I isoform alpha 125 aa 28.1% 128 aa Compounds References
Oryctolagus cuniculus Cyclin-dependent kinase 4 189 aa 28.5% 172 aa Compounds References
Rattus norvegicus Serine/threonine-protein kinase pim-3 326 aa 23.0% 309 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0022 0.5 0.5
0.0059 1 1
0.0036 0.5 0.5
0.0081 0.5 0.5
0.0042 0.5 0.5
0.0039 0.5 0.5
0.0062 0.6935 0.7231
0.0081 1 1
0.0039 0.5 0.5
0.0061 0.6883 0.6808
0.0098 0.3242 0.2614
0.0059 1 1
0.0064 0.3377 0.3377
0.0027 1 1
0.0007 0.5 0.5
0.0012 0.5 0.5
0.0039 0.9485 1
0.0007 0.5 0.5
0.0032 0.5 0.5
0.0067 0.5 0.5
0.0012 0.5 0.5
0.0033 1 1
0.0026 0.5 0.5
0.0033 0.5 0.5
0.0011 1 1
0.0007 0.5 0.5
0.0008 0.5 0.5
0.0092 1 1
0.0063 0.7244 0
0.0012 0.5 0.5
0.0032 0.5 0.5
0.0023 0.5 0.5
0.0016 0.5 0.5
0.0029 0.5 0.5
0.0091 1 1
0.0037 1 0.5
0.0093 0.8828 0
0.0069 0.3067 0.9179
0.0056 1 1
0.0016 0.5 0.5
0.0063 1 1
0.0018 0.5 0.5
0.0003 0.5 0.5
0.0066 0.3101 0
0.0088 0.4477 0.4477
0.0004 0.5 0.5
0.0059 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_12820 (Brugia malayi), Protein kinase domain containing protein
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