Detailed view for LmjF.35.1030

Basic information

TDR Targets ID: 23526
Leishmania major, zinc finger protein family member, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.2738 | Length (AA): 217 | MW (Da): 24298 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF06172   Cupin superfamily (DUF985)

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
10 202 1yud (A) 2 155 45.00 0 1 1.2 -0.21
11 205 1yud (A) 2 158 42.00 0 1 1.13 -0.34
10 204 3m3i (A) 10 204 99.99 0 1 1.92142 -0.32

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 3M3I:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_131531)

Species Accession Gene Product
Arabidopsis thaliana AT1G19130   hypothetical protein
Dictyostelium discoideum DDB_G0268166   hypothetical protein
Leishmania braziliensis LbrM.34.1020   hypothetical protein, unknown function
Leishmania donovani LdBPK_351050.1   zinc finger protein family member, putative
Leishmania infantum LinJ.35.1050   hypothetical protein, unknown function
Leishmania major LmjF.35.1030   zinc finger protein family member, putative
Leishmania mexicana LmxM.34.1030   hypothetical protein, unknown function
Mycobacterium ulcerans MUL_4460   hypothetical protein
Oryza sativa 4345750   Os08g0455800
Oryza sativa 9266408   Os06g0198600
Oryza sativa 4340398   Os06g0198500
Saccharomyces cerevisiae YML079W   hypothetical protein
Trichomonas vaginalis TVAG_587430   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

  • Lmaj012795AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Lmaj012795; Recombinant protein: full-length; Source: L major; hypothetical protein, unknown function ;

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.35.1030 (Leishmania major), zinc finger protein family member, putative
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