Detailed view for Bm1_57355

Basic information

TDR Targets ID: 235462
Brugia malayi, Zinc finger, C2H2 type family protein
Source Database / ID:  GenBank

pI: 9.3616 | Length (AA): 294 | MW (Da): 34098 | Paralog Number: 31

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00096   Zinc finger, C2H2 type

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0008270   zinc ion binding  
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
98 294 2i13 (A) 39 184 43.00 0.0000000046 1 0.559368 2.07
126 158 2em7 (A) 8 40 58.00 0.000037 0.42 0.738745 -0.15
154 186 2eog (A) 6 38 61.00 0.000013 0.9 0.838745 -0.37
238 270 2emy (A) 8 40 52.00 0.0018 0.78 0.827745 -1.28

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132371)

Species Accession Gene Product
Brugia malayi Bm1_27730   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_27645   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_57560   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_02255   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_27715   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_27630   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_23285   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_10870   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_21085   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_29525   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_08145   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_27640   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_27625   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_27725   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_11300   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_29535   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_27675   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_07100   hypothetical protein
Brugia malayi Bm1_00295   hypothetical protein
Brugia malayi Bm1_27635   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_27065   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_21475   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_17355   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_27680   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_57355   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_27080   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_15340   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_28095   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_28090   hypothetical protein
Brugia malayi Bm1_23300   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_13725   Zinc finger, C2H2 type family protein
Brugia malayi Bm1_15335   Zinc finger, C2H2 type family protein
Candida albicans CaO19.7807   low complexity orf
Loa Loa (eye worm) LOAG_16247   zinc finger protein
Loa Loa (eye worm) LOAG_15413   zinc finger protein 773
Loa Loa (eye worm) LOAG_07632   zinc finger protein 422
Loa Loa (eye worm) LOAG_11481   zinc finger protein
Loa Loa (eye worm) LOAG_15476   zinc finger protein
Loa Loa (eye worm) LOAG_13816   zinc finger protein 22
Loa Loa (eye worm) LOAG_11244   zinc finger protein
Loa Loa (eye worm) LOAG_15515   zinc finger protein
Loa Loa (eye worm) LOAG_12925   hypothetical protein
Loa Loa (eye worm) LOAG_15551   zinc finger protein 3 isoform 2
Loa Loa (eye worm) LOAG_15755   hypothetical protein
Loa Loa (eye worm) LOAG_14195   zinc finger protein
Loa Loa (eye worm) LOAG_11827   zinc finger protein
Loa Loa (eye worm) LOAG_08589   zinc finger protein 239
Loa Loa (eye worm) LOAG_15759   zinc finger protein
Loa Loa (eye worm) LOAG_12604   zinc finger protein 820
Loa Loa (eye worm) LOAG_13207   hypothetical protein
Loa Loa (eye worm) LOAG_10019   gastrula zinc finger protein XlCGF71.1
Loa Loa (eye worm) LOAG_15573   zinc finger protein
Loa Loa (eye worm) LOAG_14265   hypothetical protein
Loa Loa (eye worm) LOAG_12727   zinc finger protein
Loa Loa (eye worm) LOAG_15300   hypothetical protein
Loa Loa (eye worm) LOAG_15712   zinc finger protein
Loa Loa (eye worm) LOAG_15097   zin finger protein 595
Loa Loa (eye worm) LOAG_16050   oocyte zinc finger protein XlCOF6
Loa Loa (eye worm) LOAG_13204   zinc finger protein 578
Loa Loa (eye worm) LOAG_15764   hypothetical protein
Loa Loa (eye worm) LOAG_15031   zinc finger protein
Loa Loa (eye worm) LOAG_10029   zinc finger protein
Loa Loa (eye worm) LOAG_16163   hypothetical protein
Loa Loa (eye worm) LOAG_15132   zinc finger protein
Loa Loa (eye worm) LOAG_15338   zinc finger protein 596
Loa Loa (eye worm) LOAG_15627   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_57355 (Brugia malayi), Zinc finger, C2H2 type family protein
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