Detailed view for LmjF.36.1640
Basic information
TDR Targets ID: 23561
Leishmania major, universal minicircle sequence binding protein (UMSBP), putative
Source Database / ID: TriTrypDB GeneDB
Leishmania major, universal minicircle sequence binding protein (UMSBP), putative
Source Database / ID: TriTrypDB GeneDB
pI: 7.8196 |
Length (AA): 271 |
MW (Da): 28256 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
PF00098
Zinc knuckle
Gene Ontology
Mouse over links to read term descriptions.
GO:0008270
zinc ion binding GO:0003676 nucleic acid binding
Metabolic Pathways
This gene is not mapped to any metabolic pathway in KEGG.
Structural information
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 72 | 116 | 1aaf () | 15 | 53 | 49.00 | 0.000016 | 0.84 | 0.41 | 1.62 |
| 2 | 38 | 1f2i (G) | 1121 | 1157 | 11.00 | 0.24 | 0.04 | 0.443431 | -2.43 |
| 15 | 58 | 1a1t (A) | 12 | 49 | 50.00 | 0.000012 | 0.78 | 0.638062 | -0.57 |
| 18 | 60 | 2exf (A) | 15 | 51 | 51.00 | 0 | 0.9 | 0.596972 | -0.82 |
Help me make sense of these data.
Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
No structure availble in the PDB for this protein
Expression
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Upper 80-100% percentile | amastigotes, metacyclic. | Fernandes MC |
-
Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.
Orthologs
Ortholog group members (OG5_128115)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT2G17870 | cold shock domain protein 3 |
| Arabidopsis thaliana | AT1G75560 | CCHC-type zinc knuckle protein |
| Arabidopsis thaliana | AT4G36020 | cold shock protein 1 |
| Brugia malayi | Bm1_26265 | Zinc knuckle family protein |
| Candida albicans | CaO19.10692 | nucleic acid binding protein |
| Candida albicans | CaO19.3182 | nucleic acid binding protein |
| Caenorhabditis elegans | CELE_K08D12.3 | Protein K08D12.3, isoform B |
| Dictyostelium discoideum | DDB_G0293328 | hypothetical protein |
| Drosophila melanogaster | Dmel_CG3800 | CG3800 gene product from transcript CG3800-RA |
| Echinococcus multilocularis | EmuJ_000891600 | universal minicircle sequence binding protein (UMSBP) |
| Homo sapiens | 7555 | CCHC-type zinc finger, nucleic acid binding protein |
| Leishmania braziliensis | LbrM.35.1830 | universal minicircle sequence binding protein (UMSBP), putative |
| Leishmania donovani | LdBPK_361720.1 | universal minicircle sequence binding protein, putative |
| Leishmania infantum | LinJ.36.1720 | universal minicircle sequence binding protein (UMSBP), putative |
| Leishmania major | LmjF.36.1640 | universal minicircle sequence binding protein (UMSBP), putative |
| Leishmania mexicana | LmxM.36.1640 | universal minicircle sequence binding protein (UMSBP), putative |
| Mus musculus | ENSMUSG00000030057 | cellular nucleic acid binding protein |
| Mus musculus | ENSMUSG00000031330 | zinc finger, CCHC domain containing 13 |
| Oryza sativa | 4334596 | Os03g0820700 |
| Oryza sativa | 4349279 | Os10g0545300 |
| Saccharomyces cerevisiae | YNL255C | Gis2p |
| Schistosoma japonicum | Sjp_0200160 | ko:K09250 cellular nucleic acid-binding protein, putative |
| Schistosoma mansoni | Smp_179300.3 | cellular nucleic acid binding protein |
| Schistosoma mansoni | Smp_179300.2 | cellular nucleic acid binding protein |
| Schistosoma mansoni | Smp_179300.1 | cellular nucleic acid binding protein |
| Schmidtea mediterranea | mk4.028203.00 | |
| Schmidtea mediterranea | mk4.010278.00 | |
| Schmidtea mediterranea | mk4.009839.00 | |
| Schmidtea mediterranea | mk4.031374.00 | |
| Schmidtea mediterranea | mk4.028847.00 | |
| Schmidtea mediterranea | mk4.026437.00 | |
| Schmidtea mediterranea | mk4.032846.00 | |
| Schmidtea mediterranea | mk4.035748.00 | |
| Schmidtea mediterranea | mk4.032585.00 | |
| Schmidtea mediterranea | mk4.004918.00 | |
| Schmidtea mediterranea | mk4.002757.04 | |
| Schmidtea mediterranea | mk4.013224.01 | |
| Schmidtea mediterranea | mk4.000820.00 | |
| Schmidtea mediterranea | mk4.001718.00 | |
| Schmidtea mediterranea | mk4.015551.00 | |
| Schmidtea mediterranea | mk4.024254.00 | |
| Schmidtea mediterranea | mk4.000835.00 | |
| Schmidtea mediterranea | mk4.028647.00 | |
| Schmidtea mediterranea | mk4.003828.00 | |
| Schmidtea mediterranea | mk4.013803.02 | |
| Schmidtea mediterranea | mk4.034705.00 | |
| Schmidtea mediterranea | mk4.000931.06 | |
| Schmidtea mediterranea | mk4.001222.05 | |
| Schmidtea mediterranea | mk4.016740.00 | |
| Schmidtea mediterranea | mk4.024256.00 | |
| Schmidtea mediterranea | mk4.005496.00 | |
| Schmidtea mediterranea | mk4.023252.00 | |
| Schmidtea mediterranea | mk4.008859.00 | |
| Schmidtea mediterranea | mk4.011026.00 | |
| Schmidtea mediterranea | mk4.005785.02 | |
| Schmidtea mediterranea | mk4.020264.00 | |
| Schmidtea mediterranea | mk4.023946.00 | |
| Schmidtea mediterranea | mk4.006325.00 | |
| Schmidtea mediterranea | mk4.025590.00 | |
| Schmidtea mediterranea | mk4.030497.00 | |
| Schmidtea mediterranea | mk4.032286.00 | |
| Schmidtea mediterranea | mk4.024201.00 | |
| Schmidtea mediterranea | mk4.029030.00 | |
| Schmidtea mediterranea | mk4.006869.00 | |
| Schmidtea mediterranea | mk4.028385.00 | |
| Schmidtea mediterranea | mk4.038041.00 | |
| Schmidtea mediterranea | mk4.014408.00 | |
| Schmidtea mediterranea | mk4.029997.00 | |
| Schmidtea mediterranea | mk4.028085.00 | |
| Schmidtea mediterranea | mk4.005921.01 | |
| Schmidtea mediterranea | mk4.016807.00 | |
| Schmidtea mediterranea | mk4.000792.10 | |
| Schmidtea mediterranea | mk4.001859.01 | |
| Schmidtea mediterranea | mk4.028797.00 | |
| Schmidtea mediterranea | mk4.004330.00 | |
| Schmidtea mediterranea | mk4.014863.01 | |
| Schmidtea mediterranea | mk4.007140.01 | |
| Schmidtea mediterranea | mk4.024882.00 | |
| Schmidtea mediterranea | mk4.032010.00 | |
| Schmidtea mediterranea | mk4.020038.00 | |
| Schmidtea mediterranea | mk4.004032.03 | |
| Schmidtea mediterranea | mk4.002337.00 | |
| Schmidtea mediterranea | mk4.016990.00 | |
| Schmidtea mediterranea | mk4.010503.00 | |
| Schmidtea mediterranea | mk4.035109.00 | |
| Schmidtea mediterranea | mk4.055251.00 | |
| Schmidtea mediterranea | mk4.026833.00 | |
| Schmidtea mediterranea | mk4.026975.00 | |
| Schmidtea mediterranea | mk4.023115.00 | |
| Schmidtea mediterranea | mk4.015156.01 | |
| Schmidtea mediterranea | mk4.013701.00 | |
| Schmidtea mediterranea | mk4.019947.01 | |
| Schmidtea mediterranea | mk4.000010.21 | |
| Schmidtea mediterranea | mk4.007341.04 | |
| Schmidtea mediterranea | mk4.000098.08 | |
| Schmidtea mediterranea | mk4.029081.00 | |
| Schmidtea mediterranea | mk4.000024.12 | |
| Schmidtea mediterranea | mk4.029968.00 | |
| Schmidtea mediterranea | mk4.014117.00 | |
| Schmidtea mediterranea | mk4.035233.00 | |
| Schmidtea mediterranea | mk4.031273.00 | |
| Schmidtea mediterranea | mk4.043113.00 | |
| Schmidtea mediterranea | mk4.004739.00 | |
| Schmidtea mediterranea | mk4.007927.01 | |
| Schmidtea mediterranea | mk4.004164.03 | |
| Schmidtea mediterranea | mk4.010855.00 | |
| Schmidtea mediterranea | mk4.034910.00 | |
| Schmidtea mediterranea | mk4.005397.02 | |
| Schmidtea mediterranea | mk4.029830.00 | |
| Schmidtea mediterranea | mk4.028720.00 | |
| Schmidtea mediterranea | mk4.029077.00 | |
| Schmidtea mediterranea | mk4.017871.01 | |
| Schmidtea mediterranea | mk4.016266.00 | |
| Schmidtea mediterranea | mk4.002500.01 | |
| Schmidtea mediterranea | mk4.000143.02 | |
| Schmidtea mediterranea | mk4.028465.01 | |
| Schmidtea mediterranea | mk4.001671.01 | |
| Schmidtea mediterranea | mk4.010936.00 | |
| Schmidtea mediterranea | mk4.000061.12 | |
| Schmidtea mediterranea | mk4.028413.00 | |
| Schmidtea mediterranea | mk4.041748.00 | |
| Schmidtea mediterranea | mk4.036434.00 | |
| Schmidtea mediterranea | mk4.024435.00 | |
| Schmidtea mediterranea | mk4.029562.00 | Putative uncharacterized protein |
| Schmidtea mediterranea | mk4.022772.00 | |
| Schmidtea mediterranea | mk4.004818.00 | |
| Schmidtea mediterranea | mk4.019827.00 | |
| Schmidtea mediterranea | mk4.003270.02 | |
| Schmidtea mediterranea | mk4.000455.06 | |
| Schmidtea mediterranea | mk4.019685.00 | |
| Schmidtea mediterranea | mk4.000400.08 | |
| Schmidtea mediterranea | mk4.000165.21 | |
| Schmidtea mediterranea | mk4.024591.00 | |
| Schmidtea mediterranea | mk4.028326.00 | |
| Schmidtea mediterranea | mk4.002388.01 | |
| Schmidtea mediterranea | mk4.039915.00 | |
| Schmidtea mediterranea | mk4.004700.01 | |
| Schmidtea mediterranea | mk4.031764.00 | |
| Schmidtea mediterranea | mk4.001916.04 | |
| Schmidtea mediterranea | mk4.032169.00 | |
| Schmidtea mediterranea | mk4.001461.08 | |
| Schmidtea mediterranea | mk4.002537.02 | |
| Schmidtea mediterranea | mk4.071856.00 | |
| Schmidtea mediterranea | mk4.000772.01 | |
| Schmidtea mediterranea | mk4.016498.01 | |
| Schmidtea mediterranea | mk4.000293.02 | |
| Schmidtea mediterranea | mk4.036604.00 | |
| Schmidtea mediterranea | mk4.000056.10 | |
| Schmidtea mediterranea | mk4.012431.02 | |
| Schmidtea mediterranea | mk4.025722.00 | |
| Schmidtea mediterranea | mk4.029635.00 | |
| Schmidtea mediterranea | mk4.026866.00 | |
| Schmidtea mediterranea | mk4.028127.00 | |
| Schmidtea mediterranea | mk4.030438.00 | |
| Schmidtea mediterranea | mk4.002916.02 | |
| Schmidtea mediterranea | mk4.035931.00 | |
| Schmidtea mediterranea | mk4.026090.00 | |
| Schmidtea mediterranea | mk4.028400.00 | |
| Schmidtea mediterranea | mk4.004102.01 | |
| Schmidtea mediterranea | mk4.025060.00 | |
| Schmidtea mediterranea | mk4.008282.01 | |
| Schmidtea mediterranea | mk4.001514.01 | |
| Schmidtea mediterranea | mk4.007511.02 | |
| Schmidtea mediterranea | mk4.017023.00 | |
| Schmidtea mediterranea | mk4.032035.00 | |
| Schmidtea mediterranea | mk4.028777.00 | |
| Schmidtea mediterranea | mk4.017520.01 | |
| Schmidtea mediterranea | mk4.005425.00 | |
| Schmidtea mediterranea | mk4.004488.00 | |
| Schmidtea mediterranea | mk4.020475.00 | |
| Schmidtea mediterranea | mk4.001388.03 | Phosphomevalonate kinase |
| Schmidtea mediterranea | mk4.000978.04 | |
| Schmidtea mediterranea | mk4.000144.06 | |
| Schmidtea mediterranea | mk4.034857.00 | |
| Schmidtea mediterranea | mk4.002604.01 | |
| Schmidtea mediterranea | mk4.038013.00 | |
| Schmidtea mediterranea | mk4.028790.00 | |
| Schmidtea mediterranea | mk4.026618.00 | |
| Schmidtea mediterranea | mk4.041137.00 | |
| Schmidtea mediterranea | mk4.029101.00 | |
| Schmidtea mediterranea | mk4.020533.00 | |
| Schmidtea mediterranea | mk4.024831.00 | |
| Schmidtea mediterranea | mk4.009788.00 | |
| Schmidtea mediterranea | mk4.000362.13 | |
| Schmidtea mediterranea | mk4.005174.04 | |
| Schmidtea mediterranea | mk4.033927.00 | |
| Schmidtea mediterranea | mk4.029861.01 | |
| Schmidtea mediterranea | mk4.023029.00 | |
| Schmidtea mediterranea | mk4.000705.08 | |
| Schmidtea mediterranea | mk4.005203.03 | |
| Schmidtea mediterranea | mk4.026392.00 | |
| Schmidtea mediterranea | mk4.031994.00 | |
| Schmidtea mediterranea | mk4.009272.00 | |
| Schmidtea mediterranea | mk4.029873.00 | |
| Schmidtea mediterranea | mk4.030579.00 | |
| Schmidtea mediterranea | mk4.012359.00 | |
| Schmidtea mediterranea | mk4.002862.04 | |
| Schmidtea mediterranea | mk4.004808.01 | |
| Schmidtea mediterranea | mk4.006871.01 | |
| Schmidtea mediterranea | mk4.028211.00 | |
| Schmidtea mediterranea | mk4.022350.00 | |
| Schmidtea mediterranea | mk4.034239.00 | |
| Schmidtea mediterranea | mk4.013291.00 | |
| Schmidtea mediterranea | mk4.027747.00 | |
| Schmidtea mediterranea | mk4.044676.00 | |
| Schmidtea mediterranea | mk4.000586.05 | |
| Schmidtea mediterranea | mk4.036519.00 | |
| Schmidtea mediterranea | mk4.017480.00 | |
| Schmidtea mediterranea | mk4.028941.00 | |
| Schmidtea mediterranea | mk4.002695.06 | |
| Schmidtea mediterranea | mk4.001006.03 | |
| Schmidtea mediterranea | mk4.014394.00 | |
| Schmidtea mediterranea | mk4.007667.00 | |
| Schmidtea mediterranea | mk4.019883.00 | |
| Schmidtea mediterranea | mk4.005643.00 | |
| Schmidtea mediterranea | mk4.001549.00 | |
| Schmidtea mediterranea | mk4.026719.00 | |
| Schmidtea mediterranea | mk4.002620.03 | |
| Schmidtea mediterranea | mk4.000812.04 | |
| Schmidtea mediterranea | mk4.018537.00 | |
| Schmidtea mediterranea | mk4.031934.00 | |
| Schmidtea mediterranea | mk4.034027.00 | |
| Schmidtea mediterranea | mk4.001451.02 | |
| Schmidtea mediterranea | mk4.004186.02 | |
| Schmidtea mediterranea | mk4.003311.02 | |
| Schmidtea mediterranea | mk4.024178.00 | |
| Schmidtea mediterranea | mk4.002555.02 | |
| Schmidtea mediterranea | mk4.029919.00 | |
| Schmidtea mediterranea | mk4.005955.01 | |
| Schmidtea mediterranea | mk4.027584.00 | |
| Schmidtea mediterranea | mk4.001183.01 | |
| Schmidtea mediterranea | mk4.000221.01 | |
| Schmidtea mediterranea | mk4.031697.00 | |
| Schmidtea mediterranea | mk4.001313.07 | |
| Schmidtea mediterranea | mk4.031428.00 | |
| Schmidtea mediterranea | mk4.003097.00 | |
| Schmidtea mediterranea | mk4.027403.00 | |
| Schmidtea mediterranea | mk4.033652.00 | |
| Schmidtea mediterranea | mk4.032452.00 | |
| Schmidtea mediterranea | mk4.003085.02 | |
| Schmidtea mediterranea | mk4.026032.00 | |
| Schmidtea mediterranea | mk4.002193.04 | |
| Schmidtea mediterranea | mk4.025436.00 | |
| Schmidtea mediterranea | mk4.027781.00 | |
| Schmidtea mediterranea | mk4.008149.00 | |
| Schmidtea mediterranea | mk4.022144.00 | |
| Schmidtea mediterranea | mk4.035394.00 | |
| Schmidtea mediterranea | mk4.029015.00 | |
| Schmidtea mediterranea | mk4.024029.00 | |
| Schmidtea mediterranea | mk4.039830.00 | |
| Schmidtea mediterranea | mk4.028141.00 | |
| Schmidtea mediterranea | mk4.016265.00 | |
| Schmidtea mediterranea | mk4.023772.00 | |
| Schmidtea mediterranea | mk4.002746.00 | |
| Schmidtea mediterranea | mk4.003149.01 | |
| Schmidtea mediterranea | mk4.002120.06 | |
| Schmidtea mediterranea | mk4.032929.00 | |
| Schmidtea mediterranea | mk4.031928.00 | |
| Schmidtea mediterranea | mk4.026597.00 | |
| Schmidtea mediterranea | mk4.018118.00 | |
| Schmidtea mediterranea | mk4.022993.00 | |
| Schmidtea mediterranea | mk4.044067.00 | |
| Schmidtea mediterranea | mk4.020412.00 | |
| Schmidtea mediterranea | mk4.029963.00 | |
| Schmidtea mediterranea | mk4.024910.01 | |
| Schmidtea mediterranea | mk4.000248.06 | |
| Schmidtea mediterranea | mk4.024357.00 | |
| Schmidtea mediterranea | mk4.018287.00 | |
| Schmidtea mediterranea | mk4.009081.00 | |
| Schmidtea mediterranea | mk4.017267.00 | |
| Schmidtea mediterranea | mk4.000238.13 | |
| Schmidtea mediterranea | mk4.031471.00 | |
| Schmidtea mediterranea | mk4.027891.00 | |
| Schmidtea mediterranea | mk4.026091.00 | |
| Schmidtea mediterranea | mk4.027102.00 | |
| Schmidtea mediterranea | mk4.001109.01 | |
| Schmidtea mediterranea | mk4.023441.00 | |
| Schmidtea mediterranea | mk4.022830.00 | |
| Schmidtea mediterranea | mk4.038532.00 | |
| Schmidtea mediterranea | mk4.042813.00 | |
| Schmidtea mediterranea | mk4.008673.00 | |
| Schmidtea mediterranea | mk4.008134.00 | |
| Schmidtea mediterranea | mk4.000025.11 | |
| Schmidtea mediterranea | mk4.003740.00 | |
| Schmidtea mediterranea | mk4.000302.15 | |
| Schmidtea mediterranea | mk4.033632.00 | |
| Schmidtea mediterranea | mk4.006055.01 | |
| Schmidtea mediterranea | mk4.025305.00 | |
| Schmidtea mediterranea | mk4.006765.03 | |
| Schmidtea mediterranea | mk4.002191.01 | |
| Schmidtea mediterranea | mk4.022370.00 | |
| Schmidtea mediterranea | mk4.030145.00 | |
| Schmidtea mediterranea | mk4.016518.00 | |
| Schmidtea mediterranea | mk4.002149.14 | |
| Schmidtea mediterranea | mk4.021119.00 | |
| Schmidtea mediterranea | mk4.041592.00 | |
| Schmidtea mediterranea | mk4.024120.00 | |
| Schmidtea mediterranea | mk4.004295.04 | |
| Schmidtea mediterranea | mk4.000658.04 | |
| Schmidtea mediterranea | mk4.028703.01 | |
| Schmidtea mediterranea | mk4.026499.00 | |
| Schmidtea mediterranea | mk4.017468.00 | |
| Schmidtea mediterranea | mk4.006024.03 | |
| Schmidtea mediterranea | mk4.033666.00 | |
| Schmidtea mediterranea | mk4.003698.03 | |
| Schmidtea mediterranea | mk4.032339.00 | |
| Schmidtea mediterranea | mk4.028349.00 | |
| Schmidtea mediterranea | mk4.023747.00 | |
| Schmidtea mediterranea | mk4.001315.02 | |
| Schmidtea mediterranea | mk4.029250.00 | |
| Schmidtea mediterranea | mk4.007809.00 | |
| Schmidtea mediterranea | mk4.011760.02 | |
| Schmidtea mediterranea | mk4.026494.01 | |
| Schmidtea mediterranea | mk4.024245.00 | |
| Schmidtea mediterranea | mk4.026310.00 | |
| Schmidtea mediterranea | mk4.006294.00 | |
| Schmidtea mediterranea | mk4.044446.00 | |
| Schmidtea mediterranea | mk4.011619.00 | |
| Schmidtea mediterranea | mk4.029724.00 | |
| Schmidtea mediterranea | mk4.030395.00 | |
| Schmidtea mediterranea | mk4.006804.00 | |
| Schmidtea mediterranea | mk4.000750.02 | |
| Schmidtea mediterranea | mk4.004085.00 | |
| Schmidtea mediterranea | mk4.021137.00 | |
| Schmidtea mediterranea | mk4.029451.00 | |
| Schmidtea mediterranea | mk4.021549.00 | |
| Schmidtea mediterranea | mk4.006885.01 | |
| Schmidtea mediterranea | mk4.012368.01 | |
| Schmidtea mediterranea | mk4.007896.02 | |
| Schmidtea mediterranea | mk4.003195.03 | |
| Schmidtea mediterranea | mk4.027825.00 | |
| Schmidtea mediterranea | mk4.030209.00 | |
| Schmidtea mediterranea | mk4.012754.03 | |
| Schmidtea mediterranea | mk4.002779.00 | |
| Schmidtea mediterranea | mk4.004636.01 | |
| Schmidtea mediterranea | mk4.020374.00 | |
| Schmidtea mediterranea | mk4.029141.00 | |
| Schmidtea mediterranea | mk4.008388.00 | |
| Schmidtea mediterranea | mk4.028814.00 | |
| Schmidtea mediterranea | mk4.001841.05 | |
| Schmidtea mediterranea | mk4.029615.00 | |
| Schmidtea mediterranea | mk4.005085.01 | |
| Schmidtea mediterranea | mk4.000175.03 | |
| Schmidtea mediterranea | mk4.001149.07 | |
| Schmidtea mediterranea | mk4.013094.00 | |
| Schmidtea mediterranea | mk4.000729.12 | |
| Schmidtea mediterranea | mk4.020567.00 | |
| Schmidtea mediterranea | mk4.005420.03 | |
| Schmidtea mediterranea | mk4.015074.00 | |
| Schmidtea mediterranea | mk4.023428.00 | |
| Schmidtea mediterranea | mk4.001161.01 | |
| Schmidtea mediterranea | mk4.005260.03 | |
| Schmidtea mediterranea | mk4.030350.00 | |
| Schmidtea mediterranea | mk4.003209.01 | |
| Schmidtea mediterranea | mk4.003046.00 | |
| Schmidtea mediterranea | mk4.012732.02 | |
| Schmidtea mediterranea | mk4.023497.00 | |
| Schmidtea mediterranea | mk4.020216.00 | |
| Schmidtea mediterranea | mk4.004796.01 | |
| Schmidtea mediterranea | mk4.034770.00 | |
| Schmidtea mediterranea | mk4.023095.00 | |
| Schmidtea mediterranea | mk4.009833.01 | |
| Schmidtea mediterranea | mk4.000050.12 | |
| Schmidtea mediterranea | mk4.002234.00 | |
| Schmidtea mediterranea | mk4.031002.00 | |
| Schmidtea mediterranea | mk4.007962.00 | |
| Schmidtea mediterranea | mk4.012187.00 | |
| Schmidtea mediterranea | mk4.029463.00 | |
| Schmidtea mediterranea | mk4.029337.01 | |
| Schmidtea mediterranea | mk4.021360.00 | |
| Schmidtea mediterranea | mk4.029588.00 | |
| Schmidtea mediterranea | mk4.021962.00 | |
| Schmidtea mediterranea | mk4.002882.01 | |
| Schmidtea mediterranea | mk4.026054.00 | |
| Schmidtea mediterranea | mk4.027034.00 | |
| Schmidtea mediterranea | mk4.029438.00 | |
| Schmidtea mediterranea | mk4.000797.01 | |
| Schmidtea mediterranea | mk4.022513.00 | |
| Schmidtea mediterranea | mk4.023415.00 | |
| Schmidtea mediterranea | mk4.023770.00 | |
| Schmidtea mediterranea | mk4.036458.00 | |
| Schmidtea mediterranea | mk4.026692.00 | |
| Schmidtea mediterranea | mk4.035136.00 | |
| Schmidtea mediterranea | mk4.033856.00 | |
| Schmidtea mediterranea | mk4.027243.00 | |
| Schmidtea mediterranea | mk4.031080.00 | |
| Schmidtea mediterranea | mk4.008442.00 | |
| Schmidtea mediterranea | mk4.026933.00 | |
| Schmidtea mediterranea | mk4.006538.00 | |
| Schmidtea mediterranea | mk4.000098.04 | |
| Schmidtea mediterranea | mk4.026197.00 | |
| Schmidtea mediterranea | mk4.021994.00 | |
| Schmidtea mediterranea | mk4.001704.03 | |
| Schmidtea mediterranea | mk4.015054.00 | |
| Schmidtea mediterranea | mk4.000433.01 | |
| Schmidtea mediterranea | mk4.033315.00 | |
| Schmidtea mediterranea | mk4.017735.00 | CCHC-type zinc finger protein CG3800 |
| Trypanosoma brucei gambiense | Tbg972.10.7420 | universal minicircle sequence binding protein, putative |
| Trypanosoma brucei | Tb927.10.6060 | universal minicircle sequence binding protein 2 |
| Trypanosoma cruzi | TcCLB.503781.90 | universal minicircle sequence binding protein 2, putative |
| Trypanosoma cruzi | TcCLB.507639.20 | universal minicircle sequence binding protein, putative |
Essentiality
LmjF.36.1640 has one or more orthologs with essentiality data
| Gene/Ortholog | Organism | Phenotype | Source Study |
|---|---|---|---|
| Tb927.10.6060 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
| Tb927.10.6060 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
| Tb927.10.6060 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
| Tb927.10.6060 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
| CELE_K08D12.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
| CELE_K08D12.3 | Caenorhabditis elegans | larval arrest | wormbase |
| CELE_K08D12.3 | Caenorhabditis elegans | slow growth | wormbase |
-
nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource -
alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924 -
keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection -
neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs -
gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84 -
yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database -
wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170 -
blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930 -
shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
Phenotypes and Validation (curated)
We have no manually annotated phenotypes for this target.
What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
No validation data for this target
Associated compounds / Druggability
Druggability index (range: 0 to 1): 0.3
Known modulators for this target
No chemical compounds associated to this gene
Predicted associations
By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model
Assayability
Assay information
No assay information for this target.
Reagent availability
No reagent availability information for this target.
Bibliographic References
No literature references available for this target.
If you have references for this gene, please enter them in a user comment (below) or Contact us.
User comments
No user comments are available for this gene.
Log in to add comments, or register.