pI: 7.8196 |
Length (AA): 271 |
MW (Da): 28256 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
72 | 116 | 1aaf () | 15 | 53 | 49.00 | 0.000016 | 0.84 | 0.41 | 1.62 |
2 | 38 | 1f2i (G) | 1121 | 1157 | 11.00 | 0.24 | 0.04 | 0.443431 | -2.43 |
15 | 58 | 1a1t (A) | 12 | 49 | 50.00 | 0.000012 | 0.78 | 0.638062 | -0.57 |
18 | 60 | 2exf (A) | 15 | 51 | 51.00 | 0 | 0.9 | 0.596972 | -0.82 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | amastigotes, metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_128115)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G17870 | cold shock domain protein 3 |
Arabidopsis thaliana | AT1G75560 | CCHC-type zinc knuckle protein |
Arabidopsis thaliana | AT4G36020 | cold shock protein 1 |
Brugia malayi | Bm1_26265 | Zinc knuckle family protein |
Candida albicans | CaO19.10692 | nucleic acid binding protein |
Candida albicans | CaO19.3182 | nucleic acid binding protein |
Caenorhabditis elegans | CELE_K08D12.3 | Protein K08D12.3, isoform B |
Dictyostelium discoideum | DDB_G0293328 | hypothetical protein |
Drosophila melanogaster | Dmel_CG3800 | CG3800 gene product from transcript CG3800-RA |
Echinococcus multilocularis | EmuJ_000891600 | universal minicircle sequence binding protein (UMSBP) |
Homo sapiens | 7555 | CCHC-type zinc finger, nucleic acid binding protein |
Leishmania braziliensis | LbrM.35.1830 | universal minicircle sequence binding protein (UMSBP), putative |
Leishmania donovani | LdBPK_361720.1 | universal minicircle sequence binding protein, putative |
Leishmania infantum | LinJ.36.1720 | universal minicircle sequence binding protein (UMSBP), putative |
Leishmania major | LmjF.36.1640 | universal minicircle sequence binding protein (UMSBP), putative |
Leishmania mexicana | LmxM.36.1640 | universal minicircle sequence binding protein (UMSBP), putative |
Mus musculus | ENSMUSG00000030057 | cellular nucleic acid binding protein |
Mus musculus | ENSMUSG00000031330 | zinc finger, CCHC domain containing 13 |
Oryza sativa | 4334596 | Os03g0820700 |
Oryza sativa | 4349279 | Os10g0545300 |
Saccharomyces cerevisiae | YNL255C | Gis2p |
Schistosoma japonicum | Sjp_0200160 | ko:K09250 cellular nucleic acid-binding protein, putative |
Schistosoma mansoni | Smp_179300.3 | cellular nucleic acid binding protein |
Schistosoma mansoni | Smp_179300.2 | cellular nucleic acid binding protein |
Schistosoma mansoni | Smp_179300.1 | cellular nucleic acid binding protein |
Schmidtea mediterranea | mk4.028203.00 | |
Schmidtea mediterranea | mk4.010278.00 | |
Schmidtea mediterranea | mk4.009839.00 | |
Schmidtea mediterranea | mk4.031374.00 | |
Schmidtea mediterranea | mk4.028847.00 | |
Schmidtea mediterranea | mk4.026437.00 | |
Schmidtea mediterranea | mk4.032846.00 | |
Schmidtea mediterranea | mk4.035748.00 | |
Schmidtea mediterranea | mk4.032585.00 | |
Schmidtea mediterranea | mk4.004918.00 | |
Schmidtea mediterranea | mk4.002757.04 | |
Schmidtea mediterranea | mk4.013224.01 | |
Schmidtea mediterranea | mk4.000820.00 | |
Schmidtea mediterranea | mk4.001718.00 | |
Schmidtea mediterranea | mk4.015551.00 | |
Schmidtea mediterranea | mk4.024254.00 | |
Schmidtea mediterranea | mk4.000835.00 | |
Schmidtea mediterranea | mk4.028647.00 | |
Schmidtea mediterranea | mk4.003828.00 | |
Schmidtea mediterranea | mk4.013803.02 | |
Schmidtea mediterranea | mk4.034705.00 | |
Schmidtea mediterranea | mk4.000931.06 | |
Schmidtea mediterranea | mk4.001222.05 | |
Schmidtea mediterranea | mk4.016740.00 | |
Schmidtea mediterranea | mk4.024256.00 | |
Schmidtea mediterranea | mk4.005496.00 | |
Schmidtea mediterranea | mk4.023252.00 | |
Schmidtea mediterranea | mk4.008859.00 | |
Schmidtea mediterranea | mk4.011026.00 | |
Schmidtea mediterranea | mk4.005785.02 | |
Schmidtea mediterranea | mk4.020264.00 | |
Schmidtea mediterranea | mk4.023946.00 | |
Schmidtea mediterranea | mk4.006325.00 | |
Schmidtea mediterranea | mk4.025590.00 | |
Schmidtea mediterranea | mk4.030497.00 | |
Schmidtea mediterranea | mk4.032286.00 | |
Schmidtea mediterranea | mk4.024201.00 | |
Schmidtea mediterranea | mk4.029030.00 | |
Schmidtea mediterranea | mk4.006869.00 | |
Schmidtea mediterranea | mk4.028385.00 | |
Schmidtea mediterranea | mk4.038041.00 | |
Schmidtea mediterranea | mk4.014408.00 | |
Schmidtea mediterranea | mk4.029997.00 | |
Schmidtea mediterranea | mk4.028085.00 | |
Schmidtea mediterranea | mk4.005921.01 | |
Schmidtea mediterranea | mk4.016807.00 | |
Schmidtea mediterranea | mk4.000792.10 | |
Schmidtea mediterranea | mk4.001859.01 | |
Schmidtea mediterranea | mk4.028797.00 | |
Schmidtea mediterranea | mk4.004330.00 | |
Schmidtea mediterranea | mk4.014863.01 | |
Schmidtea mediterranea | mk4.007140.01 | |
Schmidtea mediterranea | mk4.024882.00 | |
Schmidtea mediterranea | mk4.032010.00 | |
Schmidtea mediterranea | mk4.020038.00 | |
Schmidtea mediterranea | mk4.004032.03 | |
Schmidtea mediterranea | mk4.002337.00 | |
Schmidtea mediterranea | mk4.016990.00 | |
Schmidtea mediterranea | mk4.010503.00 | |
Schmidtea mediterranea | mk4.035109.00 | |
Schmidtea mediterranea | mk4.055251.00 | |
Schmidtea mediterranea | mk4.026833.00 | |
Schmidtea mediterranea | mk4.026975.00 | |
Schmidtea mediterranea | mk4.023115.00 | |
Schmidtea mediterranea | mk4.015156.01 | |
Schmidtea mediterranea | mk4.013701.00 | |
Schmidtea mediterranea | mk4.019947.01 | |
Schmidtea mediterranea | mk4.000010.21 | |
Schmidtea mediterranea | mk4.007341.04 | |
Schmidtea mediterranea | mk4.000098.08 | |
Schmidtea mediterranea | mk4.029081.00 | |
Schmidtea mediterranea | mk4.000024.12 | |
Schmidtea mediterranea | mk4.029968.00 | |
Schmidtea mediterranea | mk4.014117.00 | |
Schmidtea mediterranea | mk4.035233.00 | |
Schmidtea mediterranea | mk4.031273.00 | |
Schmidtea mediterranea | mk4.043113.00 | |
Schmidtea mediterranea | mk4.004739.00 | |
Schmidtea mediterranea | mk4.007927.01 | |
Schmidtea mediterranea | mk4.004164.03 | |
Schmidtea mediterranea | mk4.010855.00 | |
Schmidtea mediterranea | mk4.034910.00 | |
Schmidtea mediterranea | mk4.005397.02 | |
Schmidtea mediterranea | mk4.029830.00 | |
Schmidtea mediterranea | mk4.028720.00 | |
Schmidtea mediterranea | mk4.029077.00 | |
Schmidtea mediterranea | mk4.017871.01 | |
Schmidtea mediterranea | mk4.016266.00 | |
Schmidtea mediterranea | mk4.002500.01 | |
Schmidtea mediterranea | mk4.000143.02 | |
Schmidtea mediterranea | mk4.028465.01 | |
Schmidtea mediterranea | mk4.001671.01 | |
Schmidtea mediterranea | mk4.010936.00 | |
Schmidtea mediterranea | mk4.000061.12 | |
Schmidtea mediterranea | mk4.028413.00 | |
Schmidtea mediterranea | mk4.041748.00 | |
Schmidtea mediterranea | mk4.036434.00 | |
Schmidtea mediterranea | mk4.024435.00 | |
Schmidtea mediterranea | mk4.029562.00 | Putative uncharacterized protein |
Schmidtea mediterranea | mk4.022772.00 | |
Schmidtea mediterranea | mk4.004818.00 | |
Schmidtea mediterranea | mk4.019827.00 | |
Schmidtea mediterranea | mk4.003270.02 | |
Schmidtea mediterranea | mk4.000455.06 | |
Schmidtea mediterranea | mk4.019685.00 | |
Schmidtea mediterranea | mk4.000400.08 | |
Schmidtea mediterranea | mk4.000165.21 | |
Schmidtea mediterranea | mk4.024591.00 | |
Schmidtea mediterranea | mk4.028326.00 | |
Schmidtea mediterranea | mk4.002388.01 | |
Schmidtea mediterranea | mk4.039915.00 | |
Schmidtea mediterranea | mk4.004700.01 | |
Schmidtea mediterranea | mk4.031764.00 | |
Schmidtea mediterranea | mk4.001916.04 | |
Schmidtea mediterranea | mk4.032169.00 | |
Schmidtea mediterranea | mk4.001461.08 | |
Schmidtea mediterranea | mk4.002537.02 | |
Schmidtea mediterranea | mk4.071856.00 | |
Schmidtea mediterranea | mk4.000772.01 | |
Schmidtea mediterranea | mk4.016498.01 | |
Schmidtea mediterranea | mk4.000293.02 | |
Schmidtea mediterranea | mk4.036604.00 | |
Schmidtea mediterranea | mk4.000056.10 | |
Schmidtea mediterranea | mk4.012431.02 | |
Schmidtea mediterranea | mk4.025722.00 | |
Schmidtea mediterranea | mk4.029635.00 | |
Schmidtea mediterranea | mk4.026866.00 | |
Schmidtea mediterranea | mk4.028127.00 | |
Schmidtea mediterranea | mk4.030438.00 | |
Schmidtea mediterranea | mk4.002916.02 | |
Schmidtea mediterranea | mk4.035931.00 | |
Schmidtea mediterranea | mk4.026090.00 | |
Schmidtea mediterranea | mk4.028400.00 | |
Schmidtea mediterranea | mk4.004102.01 | |
Schmidtea mediterranea | mk4.025060.00 | |
Schmidtea mediterranea | mk4.008282.01 | |
Schmidtea mediterranea | mk4.001514.01 | |
Schmidtea mediterranea | mk4.007511.02 | |
Schmidtea mediterranea | mk4.017023.00 | |
Schmidtea mediterranea | mk4.032035.00 | |
Schmidtea mediterranea | mk4.028777.00 | |
Schmidtea mediterranea | mk4.017520.01 | |
Schmidtea mediterranea | mk4.005425.00 | |
Schmidtea mediterranea | mk4.004488.00 | |
Schmidtea mediterranea | mk4.020475.00 | |
Schmidtea mediterranea | mk4.001388.03 | Phosphomevalonate kinase |
Schmidtea mediterranea | mk4.000978.04 | |
Schmidtea mediterranea | mk4.000144.06 | |
Schmidtea mediterranea | mk4.034857.00 | |
Schmidtea mediterranea | mk4.002604.01 | |
Schmidtea mediterranea | mk4.038013.00 | |
Schmidtea mediterranea | mk4.028790.00 | |
Schmidtea mediterranea | mk4.026618.00 | |
Schmidtea mediterranea | mk4.041137.00 | |
Schmidtea mediterranea | mk4.029101.00 | |
Schmidtea mediterranea | mk4.020533.00 | |
Schmidtea mediterranea | mk4.024831.00 | |
Schmidtea mediterranea | mk4.009788.00 | |
Schmidtea mediterranea | mk4.000362.13 | |
Schmidtea mediterranea | mk4.005174.04 | |
Schmidtea mediterranea | mk4.033927.00 | |
Schmidtea mediterranea | mk4.029861.01 | |
Schmidtea mediterranea | mk4.023029.00 | |
Schmidtea mediterranea | mk4.000705.08 | |
Schmidtea mediterranea | mk4.005203.03 | |
Schmidtea mediterranea | mk4.026392.00 | |
Schmidtea mediterranea | mk4.031994.00 | |
Schmidtea mediterranea | mk4.009272.00 | |
Schmidtea mediterranea | mk4.029873.00 | |
Schmidtea mediterranea | mk4.030579.00 | |
Schmidtea mediterranea | mk4.012359.00 | |
Schmidtea mediterranea | mk4.002862.04 | |
Schmidtea mediterranea | mk4.004808.01 | |
Schmidtea mediterranea | mk4.006871.01 | |
Schmidtea mediterranea | mk4.028211.00 | |
Schmidtea mediterranea | mk4.022350.00 | |
Schmidtea mediterranea | mk4.034239.00 | |
Schmidtea mediterranea | mk4.013291.00 | |
Schmidtea mediterranea | mk4.027747.00 | |
Schmidtea mediterranea | mk4.044676.00 | |
Schmidtea mediterranea | mk4.000586.05 | |
Schmidtea mediterranea | mk4.036519.00 | |
Schmidtea mediterranea | mk4.017480.00 | |
Schmidtea mediterranea | mk4.028941.00 | |
Schmidtea mediterranea | mk4.002695.06 | |
Schmidtea mediterranea | mk4.001006.03 | |
Schmidtea mediterranea | mk4.014394.00 | |
Schmidtea mediterranea | mk4.007667.00 | |
Schmidtea mediterranea | mk4.019883.00 | |
Schmidtea mediterranea | mk4.005643.00 | |
Schmidtea mediterranea | mk4.001549.00 | |
Schmidtea mediterranea | mk4.026719.00 | |
Schmidtea mediterranea | mk4.002620.03 | |
Schmidtea mediterranea | mk4.000812.04 | |
Schmidtea mediterranea | mk4.018537.00 | |
Schmidtea mediterranea | mk4.031934.00 | |
Schmidtea mediterranea | mk4.034027.00 | |
Schmidtea mediterranea | mk4.001451.02 | |
Schmidtea mediterranea | mk4.004186.02 | |
Schmidtea mediterranea | mk4.003311.02 | |
Schmidtea mediterranea | mk4.024178.00 | |
Schmidtea mediterranea | mk4.002555.02 | |
Schmidtea mediterranea | mk4.029919.00 | |
Schmidtea mediterranea | mk4.005955.01 | |
Schmidtea mediterranea | mk4.027584.00 | |
Schmidtea mediterranea | mk4.001183.01 | |
Schmidtea mediterranea | mk4.000221.01 | |
Schmidtea mediterranea | mk4.031697.00 | |
Schmidtea mediterranea | mk4.001313.07 | |
Schmidtea mediterranea | mk4.031428.00 | |
Schmidtea mediterranea | mk4.003097.00 | |
Schmidtea mediterranea | mk4.027403.00 | |
Schmidtea mediterranea | mk4.033652.00 | |
Schmidtea mediterranea | mk4.032452.00 | |
Schmidtea mediterranea | mk4.003085.02 | |
Schmidtea mediterranea | mk4.026032.00 | |
Schmidtea mediterranea | mk4.002193.04 | |
Schmidtea mediterranea | mk4.025436.00 | |
Schmidtea mediterranea | mk4.027781.00 | |
Schmidtea mediterranea | mk4.008149.00 | |
Schmidtea mediterranea | mk4.022144.00 | |
Schmidtea mediterranea | mk4.035394.00 | |
Schmidtea mediterranea | mk4.029015.00 | |
Schmidtea mediterranea | mk4.024029.00 | |
Schmidtea mediterranea | mk4.039830.00 | |
Schmidtea mediterranea | mk4.028141.00 | |
Schmidtea mediterranea | mk4.016265.00 | |
Schmidtea mediterranea | mk4.023772.00 | |
Schmidtea mediterranea | mk4.002746.00 | |
Schmidtea mediterranea | mk4.003149.01 | |
Schmidtea mediterranea | mk4.002120.06 | |
Schmidtea mediterranea | mk4.032929.00 | |
Schmidtea mediterranea | mk4.031928.00 | |
Schmidtea mediterranea | mk4.026597.00 | |
Schmidtea mediterranea | mk4.018118.00 | |
Schmidtea mediterranea | mk4.022993.00 | |
Schmidtea mediterranea | mk4.044067.00 | |
Schmidtea mediterranea | mk4.020412.00 | |
Schmidtea mediterranea | mk4.029963.00 | |
Schmidtea mediterranea | mk4.024910.01 | |
Schmidtea mediterranea | mk4.000248.06 | |
Schmidtea mediterranea | mk4.024357.00 | |
Schmidtea mediterranea | mk4.018287.00 | |
Schmidtea mediterranea | mk4.009081.00 | |
Schmidtea mediterranea | mk4.017267.00 | |
Schmidtea mediterranea | mk4.000238.13 | |
Schmidtea mediterranea | mk4.031471.00 | |
Schmidtea mediterranea | mk4.027891.00 | |
Schmidtea mediterranea | mk4.026091.00 | |
Schmidtea mediterranea | mk4.027102.00 | |
Schmidtea mediterranea | mk4.001109.01 | |
Schmidtea mediterranea | mk4.023441.00 | |
Schmidtea mediterranea | mk4.022830.00 | |
Schmidtea mediterranea | mk4.038532.00 | |
Schmidtea mediterranea | mk4.042813.00 | |
Schmidtea mediterranea | mk4.008673.00 | |
Schmidtea mediterranea | mk4.008134.00 | |
Schmidtea mediterranea | mk4.000025.11 | |
Schmidtea mediterranea | mk4.003740.00 | |
Schmidtea mediterranea | mk4.000302.15 | |
Schmidtea mediterranea | mk4.033632.00 | |
Schmidtea mediterranea | mk4.006055.01 | |
Schmidtea mediterranea | mk4.025305.00 | |
Schmidtea mediterranea | mk4.006765.03 | |
Schmidtea mediterranea | mk4.002191.01 | |
Schmidtea mediterranea | mk4.022370.00 | |
Schmidtea mediterranea | mk4.030145.00 | |
Schmidtea mediterranea | mk4.016518.00 | |
Schmidtea mediterranea | mk4.002149.14 | |
Schmidtea mediterranea | mk4.021119.00 | |
Schmidtea mediterranea | mk4.041592.00 | |
Schmidtea mediterranea | mk4.024120.00 | |
Schmidtea mediterranea | mk4.004295.04 | |
Schmidtea mediterranea | mk4.000658.04 | |
Schmidtea mediterranea | mk4.028703.01 | |
Schmidtea mediterranea | mk4.026499.00 | |
Schmidtea mediterranea | mk4.017468.00 | |
Schmidtea mediterranea | mk4.006024.03 | |
Schmidtea mediterranea | mk4.033666.00 | |
Schmidtea mediterranea | mk4.003698.03 | |
Schmidtea mediterranea | mk4.032339.00 | |
Schmidtea mediterranea | mk4.028349.00 | |
Schmidtea mediterranea | mk4.023747.00 | |
Schmidtea mediterranea | mk4.001315.02 | |
Schmidtea mediterranea | mk4.029250.00 | |
Schmidtea mediterranea | mk4.007809.00 | |
Schmidtea mediterranea | mk4.011760.02 | |
Schmidtea mediterranea | mk4.026494.01 | |
Schmidtea mediterranea | mk4.024245.00 | |
Schmidtea mediterranea | mk4.026310.00 | |
Schmidtea mediterranea | mk4.006294.00 | |
Schmidtea mediterranea | mk4.044446.00 | |
Schmidtea mediterranea | mk4.011619.00 | |
Schmidtea mediterranea | mk4.029724.00 | |
Schmidtea mediterranea | mk4.030395.00 | |
Schmidtea mediterranea | mk4.006804.00 | |
Schmidtea mediterranea | mk4.000750.02 | |
Schmidtea mediterranea | mk4.004085.00 | |
Schmidtea mediterranea | mk4.021137.00 | |
Schmidtea mediterranea | mk4.029451.00 | |
Schmidtea mediterranea | mk4.021549.00 | |
Schmidtea mediterranea | mk4.006885.01 | |
Schmidtea mediterranea | mk4.012368.01 | |
Schmidtea mediterranea | mk4.007896.02 | |
Schmidtea mediterranea | mk4.003195.03 | |
Schmidtea mediterranea | mk4.027825.00 | |
Schmidtea mediterranea | mk4.030209.00 | |
Schmidtea mediterranea | mk4.012754.03 | |
Schmidtea mediterranea | mk4.002779.00 | |
Schmidtea mediterranea | mk4.004636.01 | |
Schmidtea mediterranea | mk4.020374.00 | |
Schmidtea mediterranea | mk4.029141.00 | |
Schmidtea mediterranea | mk4.008388.00 | |
Schmidtea mediterranea | mk4.028814.00 | |
Schmidtea mediterranea | mk4.001841.05 | |
Schmidtea mediterranea | mk4.029615.00 | |
Schmidtea mediterranea | mk4.005085.01 | |
Schmidtea mediterranea | mk4.000175.03 | |
Schmidtea mediterranea | mk4.001149.07 | |
Schmidtea mediterranea | mk4.013094.00 | |
Schmidtea mediterranea | mk4.000729.12 | |
Schmidtea mediterranea | mk4.020567.00 | |
Schmidtea mediterranea | mk4.005420.03 | |
Schmidtea mediterranea | mk4.015074.00 | |
Schmidtea mediterranea | mk4.023428.00 | |
Schmidtea mediterranea | mk4.001161.01 | |
Schmidtea mediterranea | mk4.005260.03 | |
Schmidtea mediterranea | mk4.030350.00 | |
Schmidtea mediterranea | mk4.003209.01 | |
Schmidtea mediterranea | mk4.003046.00 | |
Schmidtea mediterranea | mk4.012732.02 | |
Schmidtea mediterranea | mk4.023497.00 | |
Schmidtea mediterranea | mk4.020216.00 | |
Schmidtea mediterranea | mk4.004796.01 | |
Schmidtea mediterranea | mk4.034770.00 | |
Schmidtea mediterranea | mk4.023095.00 | |
Schmidtea mediterranea | mk4.009833.01 | |
Schmidtea mediterranea | mk4.000050.12 | |
Schmidtea mediterranea | mk4.002234.00 | |
Schmidtea mediterranea | mk4.031002.00 | |
Schmidtea mediterranea | mk4.007962.00 | |
Schmidtea mediterranea | mk4.012187.00 | |
Schmidtea mediterranea | mk4.029463.00 | |
Schmidtea mediterranea | mk4.029337.01 | |
Schmidtea mediterranea | mk4.021360.00 | |
Schmidtea mediterranea | mk4.029588.00 | |
Schmidtea mediterranea | mk4.021962.00 | |
Schmidtea mediterranea | mk4.002882.01 | |
Schmidtea mediterranea | mk4.026054.00 | |
Schmidtea mediterranea | mk4.027034.00 | |
Schmidtea mediterranea | mk4.029438.00 | |
Schmidtea mediterranea | mk4.000797.01 | |
Schmidtea mediterranea | mk4.022513.00 | |
Schmidtea mediterranea | mk4.023415.00 | |
Schmidtea mediterranea | mk4.023770.00 | |
Schmidtea mediterranea | mk4.036458.00 | |
Schmidtea mediterranea | mk4.026692.00 | |
Schmidtea mediterranea | mk4.035136.00 | |
Schmidtea mediterranea | mk4.033856.00 | |
Schmidtea mediterranea | mk4.027243.00 | |
Schmidtea mediterranea | mk4.031080.00 | |
Schmidtea mediterranea | mk4.008442.00 | |
Schmidtea mediterranea | mk4.026933.00 | |
Schmidtea mediterranea | mk4.006538.00 | |
Schmidtea mediterranea | mk4.000098.04 | |
Schmidtea mediterranea | mk4.026197.00 | |
Schmidtea mediterranea | mk4.021994.00 | |
Schmidtea mediterranea | mk4.001704.03 | |
Schmidtea mediterranea | mk4.015054.00 | |
Schmidtea mediterranea | mk4.000433.01 | |
Schmidtea mediterranea | mk4.033315.00 | |
Schmidtea mediterranea | mk4.017735.00 | CCHC-type zinc finger protein CG3800 |
Trypanosoma brucei gambiense | Tbg972.10.7420 | universal minicircle sequence binding protein, putative |
Trypanosoma brucei | Tb927.10.6060 | universal minicircle sequence binding protein 2 |
Trypanosoma cruzi | TcCLB.503781.90 | universal minicircle sequence binding protein 2, putative |
Trypanosoma cruzi | TcCLB.507639.20 | universal minicircle sequence binding protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.6060 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.6060 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.6060 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.6060 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_K08D12.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K08D12.3 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K08D12.3 | Caenorhabditis elegans | slow growth | wormbase |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.3