Detailed view for Bm1_24525

Basic information

TDR Targets ID: 235617
Brugia malayi, Importin-beta N-terminal domain containing protein
Source Database / ID:  GenBank

pI: 4.9463 | Length (AA): 1082 | MW (Da): 124204 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF03810   Importin-beta N-terminal domain
PF08389   Exportin 1-like protein
PF08767   CRM1 C terminal

Gene Ontology

Mouse over links to read term descriptions.
GO:0008536   Ran GTPase binding  
GO:0005634   nucleus  
GO:0005737   cytoplasm  
GO:0005643   nuclear pore  
GO:0005488   binding  
GO:0008565   protein transporter activity  
GO:0006886   intracellular protein transport  

Metabolic Pathways

Ribosome biogenesis in eukaryotes (KEGG)
RNA transport (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
12 1068 3wyf (C) 0 1075 44.00 0 1 1.58209 -1.4
12 1066 3gjx (A) 13 1052 60.00 0 1 1.75945 -1.18
21 1079 4fgv (A) 2 1076 46.00 0 1 1.58734 -1.1
26 239 3a6p (A) 13 243 27.00 0.0000000054 1 0.505182 -0.91

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127698)

Species Accession Gene Product
Arabidopsis thaliana AT3G03110   exportin 1B
Arabidopsis thaliana AT5G17020   exportin 1A
Babesia bovis BBOV_II007220   exportin 1, putative
Brugia malayi Bm1_24525   Importin-beta N-terminal domain containing protein
Candida albicans CaO19.7483   Chromosome region maintenance protein
Caenorhabditis elegans CELE_ZK742.1   Protein XPO-1, isoform B
Cryptosporidium hominis Chro.30346   exportin 1 (chromosome region maintenance protein 1) (caffeine resistance protein 2)
Cryptosporidium parvum cgd3_3060   putative exportin 1
Dictyostelium discoideum DDB_G0291306   chromosome region maintenance protein 1
Drosophila melanogaster Dmel_CG13387   embargoed
Echinococcus granulosus EgrG_000331050   exportin 1
Entamoeba histolytica EHI_164410   hypothetical protein
Echinococcus multilocularis EmuJ_000331050   exportin 1
Giardia lamblia GL50803_93278   Hypothetical protein
Homo sapiens ENSG00000082898   exportin 1
Leishmania braziliensis LbrM.32.1200   exportin 1, putative
Leishmania donovani LdBPK_321160.1   exportin 1, putative
Leishmania infantum LinJ.32.1160   exportin 1, putative
Leishmania major LmjF.32.1100   exportin 1, putative
Leishmania mexicana LmxM.31.1100   exportin 1, putative
Loa Loa (eye worm) LOAG_06721   nuclear export factor CRM1
Loa Loa (eye worm) LOAG_10449   hypothetical protein
Loa Loa (eye worm) LOAG_10448   hypothetical protein
Mus musculus ENSMUSG00000020290   exportin 1, CRM1 homolog (yeast)
Neospora caninum NCLIV_065690   hypothetical protein
Oryza sativa 4334849   Os03g0858100
Plasmodium berghei PBANKA_0401500   exportin-1, putative
Plasmodium falciparum PF3D7_0302900   exportin-1, putative
Plasmodium knowlesi PKNH_0840200   exportin-1, putative
Plasmodium vivax PVX_119270   exportin-1, putative
Plasmodium yoelii PY01601   Plasmodium vivax PV1H14065_P-related
Plasmodium yoelii PY05627   Plasmodium vivax PV1H14065_P-related
Saccharomyces cerevisiae YGR218W   exportin CRM1
Schistosoma japonicum Sjp_0069890   Exportin-1, putative
Schistosoma mansoni Smp_124820.2   chromosome region maintenance protein 1/exportin
Schistosoma mansoni Smp_124820.1   chromosome region maintenance protein 1/exportin
Schmidtea mediterranea mk4.005143.01  
Schmidtea mediterranea mk4.005143.00  
Schmidtea mediterranea mk4.032676.00  
Schmidtea mediterranea mk4.005143.02   Exportin-1
Schmidtea mediterranea mk4.000191.02   Exportin-1
Trypanosoma brucei gambiense Tbg972.11.16060   exportin 1, putative
Trypanosoma brucei Tb927.11.14340   exportin 1
Trypanosoma cruzi TcCLB.511725.150   exportin 1, putative
Toxoplasma gondii TGME49_249530   exportin 1, putative
Theileria parva TP02_0177   importin beta-related nuclear transport factor, putative
Trichomonas vaginalis TVAG_380190   chromosome region maintenance protein, putative
Trichomonas vaginalis TVAG_295160   chromosome region maintenance protein, putative

Essentiality

Bm1_24525 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.5940 Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.5940 Trypanosoma brucei significant gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.5940 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb11.01.5940 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_ZK742.1 Caenorhabditis elegans embryonic lethal wormbase
CELE_ZK742.1 Caenorhabditis elegans larval arrest wormbase
CELE_ZK742.1 Caenorhabditis elegans larval lethal wormbase
CELE_ZK742.1 Caenorhabditis elegans slow growth wormbase
CELE_ZK742.1 Caenorhabditis elegans sterile wormbase
YGR218W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0401500 Plasmodium berghei Essential plasmo
TGME49_249530 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens exportin 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0275 0.2888 0.2453
0.0098 0.663 0.5694
0.033 0.9107 0
0.0098 0.663 0.5694
0.0168 0.5508 0.5508
0.0297 0.623 0.623
0.0173 0.5493 0.5493
0.0098 0.663 0.5694
0.033 0.9107 0
0.0516 0.535 1
0.0435 0.2796 1
0.0059 0.2924 0.5
0.0435 0.2796 1
0.006 0.2549 0
0.0076 0.9773 0
0.0303 0.6427 1
0.006 0.2549 0
0.0232 0.3169 0.3063
0.0297 0.623 0.623

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Bm1_24525 (Brugia malayi), Importin-beta N-terminal domain containing protein
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