Detailed view for Bm1_49215

Basic information

TDR Targets ID: 235666
Brugia malayi, B-box zinc finger family protein
Source Database / ID:  GenBank

pI: 6.5474 | Length (AA): 972 | MW (Da): 106075 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00630   Filamin/ABP280 repeat
PF01436   NHL repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0008270   zinc ion binding  
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
90 128 1chc (A) 8 46 44.00 0.12 0.86 0.416523 0.89
329 439 5iea (A) 95 221 23.00 0 1 0.441098 -1.01
643 891 1q7f (A) 768 1006 22.00 0 1 0.524073 -0.29
645 873 1q7f (A) 770 989 34.00 0 1 0.682997 -1.18

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131005)

Species Accession Gene Product
Brugia malayi Bm1_04980   Hypothetical RING finger protein F54G8.4 in chromosome III
Brugia malayi Bm1_49215   B-box zinc finger family protein
Caenorhabditis elegans CELE_F54G8.4   Protein NHL-1
Caenorhabditis elegans CELE_C12C8.3   Protein LIN-41, isoform B
Drosophila melanogaster Dmel_CG42396   CG42396 gene product from transcript CG42396-RC
Drosophila melanogaster Dmel_CG15105   thin
Echinococcus granulosus EgrG_000846350   Zinc finger RING type
Echinococcus multilocularis EmuJ_000846350   Zinc finger, RING type
Homo sapiens 131405   tripartite motif containing 71, E3 ubiquitin protein ligase
Loa Loa (eye worm) LOAG_07941   RING finger protein nhl-1
Loa Loa (eye worm) LOAG_09874   B-box zinc finger family protein
Loa Loa (eye worm) LOAG_12948   hypothetical protein
Mus musculus 636931   tripartite motif-containing 71
Schmidtea mediterranea mk4.007666.00   RING finger protein nhl-1
Schmidtea mediterranea mk4.006495.00   RING finger protein nhl-1
Schmidtea mediterranea mk4.029896.00   RING finger protein nhl-1
Treponema pallidum TP0421   hypothetical protein

Essentiality

Bm1_49215 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C12C8.3 Caenorhabditis elegans adult lethal wormbase
CELE_C12C8.3 Caenorhabditis elegans larval lethal wormbase
CELE_C12C8.3 Caenorhabditis elegans slow growth wormbase
CELE_C12C8.3 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_49215 (Brugia malayi), B-box zinc finger family protein
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