Detailed view for Bm1_21575

Basic information

TDR Targets ID: 235739
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 6.0165 | Length (AA): 916 | MW (Da): 102582 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00415   Regulator of chromosome condensation (RCC1) repeat
PF00632   HECT-domain (ubiquitin-transferase)
PF13540   Regulator of chromosome condensation (RCC1) repeat

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0016881   acid-amino acid ligase activity  
GO:0004842   ubiquitin-protein ligase activity  
GO:0006464   protein modification process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 13 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 63 4o2w (A) 4308 4359 31.00 0.00039 0.47 0.175886 0.26
4 348 3mvd (K) 42 378 19.00 0.062 1 0.557838 0.36
5 307 4jhn (A) 55 340 33.00 0 1 0.679986 -0.05
8 322 4o2w (A) 4048 4351 31.00 0 1 0.653086 -0.25
40 329 4jhn (A) 28 364 23.00 0 1 0.447294 0.1
43 331 4l1m (A) 447 724 27.00 0 1 0.551702 -0.02
49 330 3qhy (B) 66 310 32.00 0.00000001 1 0.35806 0.34
121 348 4o2w (A) 3999 4218 27.00 0 0.98 0.539608 0.22
212 276 4nbm (A) 15 79 25.00 0 0.32 0.370661 -0.37
505 910 3olm (A) 393 803 26.00 0 1 0.641431 0.59
537 909 3h1d (A) 3987 4366 28.00 0 1 0.741405 -0.27
564 909 1c4z (A) 497 845 36.00 0 1 0.804429 -0.24
816 908 3pt3 (A) 2697 2792 26.00 0 0.53 0.337228 -0.52

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129534)

Species Accession Gene Product
Brugia malayi Bm1_14645   hypothetical protein
Brugia malayi Bm1_21575   hypothetical protein
Caenorhabditis elegans CELE_Y48G8AL.1   Protein HERC-1
Drosophila melanogaster Dmel_CG9153   CG9153 gene product from transcript CG9153-RA
Echinococcus granulosus EgrG_000424000   E3 ubiquitin protein ligase HERC4
Echinococcus multilocularis EmuJ_000424000   E3 ubiquitin protein ligase HERC4
Homo sapiens ENSG00000148634   HECT and RLD domain containing E3 ubiquitin protein ligase 4
Homo sapiens ENSG00000246375   HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
Homo sapiens ENSG00000138646   HECT and RLD domain containing E3 ubiquitin protein ligase 5
Homo sapiens ENSG00000138641   HECT and RLD domain containing E3 ubiquitin protein ligase 3
Loa Loa (eye worm) LOAG_09523   hypothetical protein
Loa Loa (eye worm) LOAG_06486   hypothetical protein
Mus musculus ENSMUSG00000029798   hect domain and RLD 6
Mus musculus ENSMUSG00000020064   hect domain and RLD 4
Mus musculus ENSMUSG00000029804   hect domain and RLD 3
Schistosoma japonicum Sjp_0079500   ko:K10615 E3 ubiquitin-protein ligase HERC4, putative
Schistosoma japonicum Sjp_0069480   Probable E3 ubiquitin-protein ligase HERC4, putative
Schistosoma mansoni Smp_142890   ubiquitin ligase
Schmidtea mediterranea mk4.001048.00  
Schmidtea mediterranea mk4.008623.04  
Schmidtea mediterranea mk4.000303.05  
Schmidtea mediterranea mk4.004892.00  
Schmidtea mediterranea mk4.000303.04  
Schmidtea mediterranea mk4.000303.06  
Trichomonas vaginalis TVAG_050760   hect E3 ubiquitin ligase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Sus scrofa Elastase 2A 269 aa 23.5% 234 aa Compounds References
Sus scrofa Pancreatic elastase 269 aa 23.5% 234 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_21575 (Brugia malayi), hypothetical protein
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