Detailed view for LmjF.28.0090
Basic information
Leishmania major, adenylate cyclase-like protein
Source Database / ID: TriTrypDB GeneDB
pI: 6.239 |
Length (AA): 616 |
MW (Da): 70524 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Gene Ontology
GO:0020037 heme binding
GO:0019825 oxygen binding
GO:0016849 phosphorus-oxygen lyase activity
GO:0005506 iron ion binding
GO:0015671 oxygen transport
GO:0009190 cyclic nucleotide biosynthetic process
GO:0007242 intracellular signaling cascade
Metabolic Pathways
Structural information
Modbase 3D models:
There are 9 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 36 | 214 | 1c7c (A) | 103 | 283 | 17.00 | 0 | 0.46 | 0.53 | -1.23 |
| 77 | 215 | 1jf4 (A) | 1 | 147 | 19.00 | 0 | 1 | 0.67 | -2.24 |
| 78 | 210 | 1yhu (B) | 4 | 143 | 16.00 | 0 | 0.99 | 0.58 | -2.45 |
| 368 | 608 | 1fx2 (A) | 888 | 1112 | 34.00 | 0 | 1 | 0.64 | -0.67 |
| 374 | 541 | 1fx2 (A) | 894 | 1075 | 41.00 | 0 | 1 | 0.76 | -1.07 |
| 77 | 214 | 1a4f (B) | 2 | 146 | 17.00 | 0.0000029 | 1 | 0.509926 | -1.67 |
| 85 | 212 | 1xq5 (A) | 9 | 140 | 16.00 | 0 | 0.99 | 0.504792 | -1.63 |
| 86 | 209 | 1x9f (D) | 10 | 139 | 15.00 | 0 | 1 | 0.510299 | -1.86 |
| 374 | 607 | 1fx4 (A) | 882 | 1099 | 38.00 | 0 | 1 | 0.61717 | -0.04 |
Help me make sense of these data.
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Expression
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Upper 60-80% percentile | metacyclic. | Fernandes MC |
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Mid 40-60% percentile | amastigotes. | Fernandes MC |
-
Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.
Orthologs
Ortholog group members (OG5_173496)
| Species | Accession | Gene Product |
|---|---|---|
| Leishmania donovani | LdBPK_280090.1 | oxygen-sensing adenylate cyclase |
| Leishmania infantum | LinJ.28.0090 | adenylate cyclase-like protein |
| Leishmania major | LmjF.28.0090 | adenylate cyclase-like protein |
| Leishmania mexicana | LmxM.28.0090 | adenylate cyclase-like protein |
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
By sequence similarity to non orthologous druggable targets
Obtained from network model
Assayability
Assay information
- Assay for Adenylate Cyclase (4.6.1.1 ) Sigma-Aldrich
- Automatic link to known assays based on EC numbers.
Reagent availability
Bibliographic References
8 literature references were collected for this gene.