Detailed view for Bm1_20185

Basic information

TDR Targets ID: 235881
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 9.1745 | Length (AA): 212 | MW (Da): 24503 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00071   Ras family
PF08477   Ras of Complex, Roc, domain of DAPkinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0005525   GTP binding  
GO:0003924   GTPase activity  
GO:0015031   protein transport  
GO:0007264   small GTPase mediated signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
49 207 3c5c (A) 21 160 18.00 0 0.5 0.655 0.21
50 209 1u8z (A) 16 155 28.00 0.00026 1 0.854017 0.13
50 207 4djt (A) 9 145 36.00 0.00006 0.58 0.756583 0.59
181 210 2kwi (A) 128 157 27.00 0.087 0.1 0.433109 -0.24

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131835)

Species Accession Gene Product
Brugia malayi Bm1_20185   hypothetical protein
Caenorhabditis elegans CELE_F08G12.1   Protein F08G12.1
Dictyostelium discoideum DDB_G0270744   Rab GTPase domain-containing protein
Echinococcus granulosus EgrG_000682800   GTP binding protein Parf
Echinococcus multilocularis EmuJ_000682800   GTP binding protein Parf
Homo sapiens ENSG00000196642   RAB, member RAS oncogene family-like 6
Loa Loa (eye worm) LOAG_05540   hypothetical protein
Mus musculus ensembl-mmu:ENSMUSG00000015087   RAB, member RAS oncogene family-like 6
Schistosoma japonicum Sjp_0037880   Putative GTP-binding protein Parf, putative
Schistosoma mansoni Smp_062680   hypothetical protein
Trichomonas vaginalis TVAG_452380   hypothetical protein
Trichomonas vaginalis TVAG_210400   conserved hypothetical protein
Trichomonas vaginalis TVAG_286340   Intracellular protein transport protein USO1, putative
Trichomonas vaginalis TVAG_074830   conserved hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_20185 (Brugia malayi), hypothetical protein
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