Detailed view for Bm1_05660

Basic information

TDR Targets ID: 236028
Brugia malayi, signal transduction protein CBL-B
Source Database / ID:  GenBank

pI: 8.5677 | Length (AA): 564 | MW (Da): 63609 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02262   CBL proto-oncogene N-terminal domain 1
PF02761   CBL proto-oncogene N-terminus, EF hand-like domain
PF02762   CBL proto-oncogene N-terminus, SH2-like domain
PF14447   Prokaryotic RING finger family 4

Gene Ontology

Mouse over links to read term descriptions.
GO:0023051   GO:regulation of signaling  

GO:0001784   phosphotyrosine binding  
GO:0005634   nucleus  
GO:0008270   zinc ion binding  
GO:0005515   protein binding  
GO:0005509   calcium ion binding  
GO:0004871   signal transducer activity  
GO:0004842   ubiquitin-protein ligase activity  
GO:0007166   cell surface receptor linked signal transduction  

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
44 344 3op0 (A) 11 322 48.00 0 1 1.20969 -1.62
47 428 2y1n (C) 52 435 67.00 0 1 1.5621 -1.4
346 413 2ldr (A) 346 413 58.00 0.0012 1 0.776567 0.08
371 423 1z6u (A) 731 782 29.00 0 0.63 0.467072 -0.51
372 417 4r7e (A) 647 691 29.00 0 1 0.51566 -0.78

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_131130)

Species Accession Gene Product
Brugia malayi Bm1_05660   signal transduction protein CBL-B
Caenorhabditis elegans CELE_M02A10.3   Protein SLI-1, isoform C
Drosophila melanogaster Dmel_CG7037   CG7037 gene product from transcript CG7037-RB
Echinococcus granulosus EgrG_000424900   E3 ubiquitin protein ligase CBL
Echinococcus multilocularis EmuJ_000424900   E3 ubiquitin protein ligase CBL
Echinococcus multilocularis EmuJ_001016000   expressed protein
Homo sapiens ENSG00000110395   Cbl proto-oncogene, E3 ubiquitin protein ligase
Homo sapiens ENSG00000114423   Cbl proto-oncogene B, E3 ubiquitin protein ligase
Loa Loa (eye worm) LOAG_05836   signal transduction protein CBL-B
Mus musculus ENSMUSG00000022637   Casitas B-lineage lymphoma b
Mus musculus ENSMUSG00000034342   Casitas B-lineage lymphoma
Schistosoma japonicum Sjp_0077150   ko:K04707 E3 ubiquitin-protein ligase CBL, putative
Schistosoma mansoni Smp_005020   cbl
Schmidtea mediterranea mk4.001160.01  
Schmidtea mediterranea mk4.011699.01  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Bm1_05660 (Brugia malayi), signal transduction protein CBL-B
Title for this comment
Comment