Detailed view for Bm1_16775

Basic information

TDR Targets ID: 236247
Brugia malayi, Glycogenin-1
Source Database / ID:  GenBank

pI: 6.8094 | Length (AA): 412 | MW (Da): 45683 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01501   Glycosyl transferase family 8

Gene Ontology

Mouse over links to read term descriptions.
GO:0016757   transferase activity, transferring glycosyl groups  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 243 4ueg (A) 6 260 52.00 0 1 1.28155 -1.29
3 250 3u2u (A) 4 251 52.00 0 1 1.30304 -0.94
378 411 4qlb (G) 268 301 59.00 0.0000027 0.76 0.802124 -0.66

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129465)

Species Accession Gene Product
Brugia malayi Bm1_16775   Glycogenin-1
Candida albicans CaO19.7434   one of two potential glycoprotein glucosyltransferase genes similar to S. cerevisiae GLG2 (YJL137C) self-glucosylating initiator
Caenorhabditis elegans CELE_T25E12.5   Protein GYG-2
Caenorhabditis elegans CELE_F56B6.4   Protein GYG-1, isoform A
Drosophila melanogaster Dmel_CG44244   CG44244 gene product from transcript CG44244-RE
Echinococcus granulosus EgrG_000801500   glycogenin 1
Echinococcus granulosus EgrG_000194000   glycogenin 1
Echinococcus multilocularis EmuJ_000801500   glycogenin 1
Echinococcus multilocularis EmuJ_000194000   glycogenin 1
Homo sapiens ENSG00000056998   glycogenin 2
Homo sapiens ENSG00000163754   glycogenin 1
Loa Loa (eye worm) LOAG_04688   hypothetical protein
Mus musculus ENSMUSG00000019528   glycogenin
Saccharomyces cerevisiae YKR058W   glycogenin glucosyltransferase GLG1
Schistosoma japonicum Sjp_0303640   ko:K00750 glycogenin glucosyltransferase [EC2.4.1.186], putative
Schistosoma mansoni Smp_008490   glycogenin-related
Schmidtea mediterranea mk4.000025.19   Glycogenin-related
Schmidtea mediterranea mk4.008298.01   Glycogenin-related
Schmidtea mediterranea mk4.001506.05  
Toxoplasma gondii TGME49_310400   glycosyl transferase family 8 protein
Trichomonas vaginalis TVAG_014980   glycogenin, putative
Trichomonas vaginalis TVAG_070520   glycogenin, putative

Essentiality

Bm1_16775 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F56B6.4 Caenorhabditis elegans embryonic lethal wormbase
CELE_F56B6.4 Caenorhabditis elegans larval arrest wormbase
TGME49_310400 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Neisseria meningitidis Alpha 1,4 galactosyltransferase 310 aa 25.4% 256 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_16775 (Brugia malayi), Glycogenin-1
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