Detailed view for Bm1_39935

Basic information

TDR Targets ID: 236371
Brugia malayi, Cache domain containing protein
Source Database / ID:  GenBank

pI: 7.3414 | Length (AA): 1298 | MW (Da): 148651 | Paralog Number: 0

Signal peptide: N | GPI Anchor: Y | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF08399   VWA N-terminal
PF13519   von Willebrand factor type A domain
PF13768   von Willebrand factor type A domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  

Metabolic Pathways

MAPK signaling pathway (KEGG)

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
256 492 5a8j (A) 35 203 21.00 0 0.95 -0.0525114 0.65
258 368 2xgg (A) 72 180 19.00 0 0.41 0.241416 -0.25
507 597 3c8c (A) 161 257 21.00 0 0.62 0.194008 0.57
517 582 3li9 (A) 165 236 32.00 0.49 0.79 0.236247 1.08

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129581)

Species Accession Gene Product
Brugia malayi Bm1_39935   Cache domain containing protein
Caenorhabditis elegans CELE_C50C3.9   Protein UNC-36, isoform B
Drosophila melanogaster Dmel_CG42817   CG42817 gene product from transcript CG42817-RB
Drosophila melanogaster Dmel_CG42818   CG42818 gene product from transcript CG42818-RB
Drosophila melanogaster Dmel_CG12295   straightjacket
Drosophila melanogaster Dmel_CG4587   CG4587 gene product from transcript CG4587-RM
Echinococcus granulosus EgrG_000895200   voltage dependent calcium channel subunit
Echinococcus multilocularis EmuJ_000895200   voltage dependent calcium channel subunit
Homo sapiens ENSG00000157445   calcium channel, voltage-dependent, alpha 2/delta subunit 3
Homo sapiens ENSG00000151062   calcium channel, voltage-dependent, alpha 2/delta subunit 4
Loa Loa (eye worm) LOAG_07774   hypothetical protein
Loa Loa (eye worm) LOAG_13572   hypothetical protein
Mus musculus ENSMUSG00000041460   calcium channel, voltage-dependent, alpha 2/delta subunit 4
Mus musculus ENSMUSG00000021991   calcium channel, voltage-dependent, alpha2/delta subunit 3
Schistosoma japonicum Sjp_0045590   ko:K04860 calcium channel, voltage-dependent, alpha 2/delta subunit 3, putative
Schistosoma japonicum Sjp_0045570   hypothetical protein
Schistosoma mansoni Smp_134050   dihydropyridine-sensitive l-type calcium channel
Schmidtea mediterranea mk4.003092.03   Voltage-dependent calcium channel unc-36

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens calcium channel, voltage-dependent, alpha 2/delta subunit 3 Compounds References
Homo sapiens calcium channel, voltage-dependent, alpha 2/delta subunit 4 Compounds References
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Voltage-gated calcium channel alpha2/delta subunit 1 1091 aa 23.4% 1090 aa Compounds References
Sus scrofa Voltage-dependent calcium channel alpha2delta subunit 1091 aa 23.6% 1135 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.05 0.3356 0.2524
0.0534 0.4049 0.4076

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_39935 (Brugia malayi), Cache domain containing protein
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