Detailed view for Bm1_57505

Basic information

TDR Targets ID: 236439
Brugia malayi, Protein C20orf11 homolog
Source Database / ID:  GenBank

pI: 4.5791 | Length (AA): 239 | MW (Da): 27219 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF10607   CTLH/CRA C-terminal to LisH motif domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005515   protein binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128400)

Species Accession Gene Product
Arabidopsis thaliana AT4G09300   LisH and RanBPM domain-containing protein
Arabidopsis thaliana AT1G61150   LisH and RanBPM domain-containing protein
Babesia bovis BBOV_I004410   conserved hypothetical protein
Brugia malayi Bm1_57505   Protein C20orf11 homolog
Candida albicans CaO19.11287   similar to S. pombe SPAC12B10.13 and to S. cerevisiae GID8 (YMR135C) negative regulator of gluconeogenesis
Candida albicans CaO19.3806   similar to S. pombe SPAC12B10.13 and to S. cerevisiae GID8 (YMR135C) negative regulator of gluconeogenesis
Caenorhabditis elegans CELE_F53E2.1   Protein TAG-304
Dictyostelium discoideum DDB_G0279265   UPF0559 protein
Drosophila melanogaster Dmel_CG6617   CG6617 gene product from transcript CG6617-RA
Drosophila melanogaster Dmel_CG18467   CG18467 gene product from transcript CG18467-RA
Echinococcus granulosus EgrG_001047200   ran binding protein 9
Echinococcus granulosus EgrG_000979000   myeloid:lymphoid or mixed lineage leukemia 5
Echinococcus multilocularis EmuJ_001047200   ran binding protein 9
Echinococcus multilocularis EmuJ_000979000   myeloid:lymphoid or mixed lineage leukemia 5
Homo sapiens ENSG00000101193   GID complex subunit 8
Loa Loa (eye worm) LOAG_10529   hypothetical protein
Mus musculus ENSMUSG00000027573   GID complex subunit 8 homolog (S. cerevisiae)
Neospora caninum NCLIV_057780   hypothetical protein
Oryza sativa 4332176   Os03g0235100
Plasmodium berghei PBANKA_1350300   RanBPM and CLTH-like protein, putative
Plasmodium falciparum PF3D7_1336400   RanBPM and CLTH-like protein, putative
Plasmodium knowlesi PKNH_1264800   RanBPM and CLTH-like protein, putative
Plasmodium vivax PVX_082755   RanBPM and CLTH-like protein, putative
Plasmodium yoelii PY01503   hypothetical protein
Saccharomyces cerevisiae YMR135C   glucose-induced degradation complex subunit GID8
Schistosoma japonicum Sjp_0006860   Protein C20orf11 homolog, putative
Schistosoma japonicum Sjp_0304280   Protein C20orf11 homolog, putative
Schistosoma japonicum Sjp_0070020   ko:K09189 myeloid/lymphoid or mixed-lineage leukemia protein 5, putative
Schistosoma mansoni Smp_009980   ran binding protein 9-related
Schmidtea mediterranea mk4.012961.00   Glucose-induced degradation protein 8 homolog
Schmidtea mediterranea mk4.002520.00   Glucose-induced degradation protein 8 homolog
Toxoplasma gondii TGME49_314900   LisH protein
Theileria parva TP01_0182   hypothetical protein, conserved

Essentiality

Bm1_57505 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
TGME49_314900 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_57505 (Brugia malayi), Protein C20orf11 homolog
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