pI: 4.0024 |
Length (AA): 247 |
MW (Da): 27272 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
10 | 245 | 3ceg (A) | 4536 | 4761 | 24.00 | 0 | 1 | 1.08947 | -0.3 |
17 | 193 | 3rz3 (A) | 6 | 183 | 68.00 | 0 | 1 | 1.5466 | -1.5 |
21 | 154 | 1zdn (A) | 13 | 133 | 36.00 | 0 | 1 | 1.05581 | -1.64 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_129084)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_12705 | ubiquitin conjugating enzyme protein 3 |
Candida albicans | CaO19_6529 | hypothetical protein |
Candida albicans | CaO19.13882 | ubiquitin-conjugating enzyme |
Candida albicans | CaO19.6529 | ubiquitin-conjugating enzyme |
Caenorhabditis elegans | CELE_Y71G12B.15 | Protein UBC-3 |
Dictyostelium discoideum | DDB_G0284009 | ubiquitin-conjugating enzyme E2 |
Dictyostelium discoideum | DDB_G0288345 | hypothetical protein |
Drosophila melanogaster | Dmel_CG7656 | CG7656 gene product from transcript CG7656-RF |
Echinococcus granulosus | EgrG_000957600 | ubiquitin conjugating enzyme e2 r1 |
Entamoeba histolytica | EHI_100110 | ubiquitin-conjugating enzyme family protein |
Echinococcus multilocularis | EmuJ_000957600 | ubiquitin conjugating enzyme e2 r1 |
Homo sapiens | ENSG00000099804 | cell division cycle 34 |
Homo sapiens | ENSG00000107341 | ubiquitin-conjugating enzyme E2R 2 |
Leishmania braziliensis | LbrM.32.1050 | ubiquitin-conjugating enzyme protein, putative |
Leishmania donovani | LdBPK_321010.1 | ubiquitin-conjugating enzyme protein, putative |
Leishmania infantum | LinJ.32.1010 | ubiquitin-conjugating enzyme protein, putative |
Leishmania major | LmjF.32.0960 | ubiquitin-conjugating enzyme protein, putative |
Leishmania mexicana | LmxM.31.0960 | ubiquitin-conjugating enzyme protein, putative |
Loa Loa (eye worm) | LOAG_11770 | ubiquitin conjugating enzyme protein 3 |
Mus musculus | ENSMUSG00000020307 | cell division cycle 34 |
Mus musculus | ENSMUSG00000036241 | ubiquitin-conjugating enzyme E2R 2 |
Saccharomyces cerevisiae | YDR054C | SCF E2 ubiquitin-protein ligase catalytic subunit CDC34 |
Schistosoma japonicum | Sjp_0015960 | ko:K02207 ubiquitin-conjugating enzyme E2 R, putative |
Schistosoma mansoni | Smp_055960 | ubiquitin-conjugating enzyme E2r |
Schmidtea mediterranea | mk4.006526.00 | |
Schmidtea mediterranea | mk4.012783.00 | |
Trichomonas vaginalis | TVAG_297260 | ubiquitin-conjugating enzyme E2, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
YDR054C | Saccharomyces cerevisiae | inviable | yeastgenome |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.