Detailed view for Bm1_17910

Basic information

TDR Targets ID: 236497
Brugia malayi, hypothetical protein
Source Database / ID:  GenBank

pI: 4.5342 | Length (AA): 634 | MW (Da): 72626 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02724   CDC45-like protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0006270   DNA replication initiation  

Metabolic Pathways

Cell cycle (KEGG)

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 619 5dgo (A) 1 548 27.00 0 1 1.07136 0.48
153 259 1gpj (A) 263 367 35.00 0.96 0.07 0.35117 0.37
166 252 5hmo (A) 819 907 18.00 0.1 0 0.376824 -1.05

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129331)

Species Accession Gene Product
Arabidopsis thaliana AT3G25100   cell division control protein 45
Brugia malayi Bm1_17910   hypothetical protein
Candida albicans CaO19.1988   Similar to S. cerevisiae CDC45 (YLR103C) chromosomal DNA replication initiation protein
Caenorhabditis elegans CELE_F34D10.9   Protein F34D10.9
Caenorhabditis elegans CELE_F34D10.2   Protein EVL-18
Dictyostelium discoideum DDB_G0267748   cell division cycle protein 45
Drosophila melanogaster Dmel_CG3658   CG3658 gene product from transcript CG3658-RA
Echinococcus granulosus EgrG_000787200   cell division control protein 45
Entamoeba histolytica EHI_049900   cell division control protein 45 CDC45, putative
Echinococcus multilocularis EmuJ_000787200   cell division control protein 45
Homo sapiens ENSG00000093009   cell division cycle 45
Loa Loa (eye worm) LOAG_05332   hypothetical protein
Mus musculus ENSMUSG00000000028   cell division cycle 45
Oryza sativa 4351377   Os12g0124700
Oryza sativa 4349656   Os11g0128400
Saccharomyces cerevisiae YLR103C   Cdc45p
Schistosoma mansoni Smp_047610   cell division control protein 45-related
Schmidtea mediterranea mk4.000433.08   Cell division control protein 45 homolog
Schmidtea mediterranea mk4.018968.00   Cdc45-like protein
Schmidtea mediterranea mk4.017051.00   Cell division control protein 45 homolog
Trichomonas vaginalis TVAG_128240   conserved hypothetical protein

Essentiality

Bm1_17910 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F34D10.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_F34D10.2 Caenorhabditis elegans sterile wormbase
YLR103C Saccharomyces cerevisiae inviable yeastgenome
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens cell division cycle 45 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.012 0.3657 0.6216
0.0116 0.2551 0.4322
0.0101 0.5043 0.7518

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_17910 (Brugia malayi), hypothetical protein
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