Detailed view for Bm1_36705

Basic information

TDR Targets ID: 236554
Brugia malayi, KOW motif family protein
Source Database / ID:  GenBank

pI: 8.7018 | Length (AA): 456 | MW (Da): 51172 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12656   G-patch domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005622   intracellular  
GO:0003676   nucleic acid binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
58 153 3qqm (A) 61 160 34.00 0.47 0.32 0.225726 1.11
221 265 2mi6 (A) 9 53 16.00 0 0.1 0.218684 0.33
335 448 2ckk (A) 10 125 24.00 0 1 0.5718 -0.4

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130356)

Species Accession Gene Product
Arabidopsis thaliana AT1G33520   protein MOS2
Arabidopsis thaliana AT4G25020   D111/G-patch domain-containing protein
Brugia malayi Bm1_36705   KOW motif family protein
Caenorhabditis elegans CELE_R11A8.2   Protein R11A8.2
Caenorhabditis elegans CELE_F53B2.1   Protein F53B2.1
Dictyostelium discoideum DDB_G0289933   hypothetical protein
Drosophila melanogaster Dmel_CG10324   CG10324 gene product from transcript CG10324-RA
Echinococcus granulosus EgrG_000827950   G patch domain and KOW motifs containing
Entamoeba histolytica EHI_200340   hypothetical protein
Echinococcus multilocularis EmuJ_000827950   G patch domain and KOW motifs containing
Homo sapiens ENSG00000068394   G patch domain and KOW motifs
Loa Loa (eye worm) LOAG_02889   KOW domain-containing protein family protein
Mus musculus ENSMUSG00000031148   G patch domain and KOW motifs
Oryza sativa 4332278   Os03g0253500
Onchocerca volvulus OVOC4565  
Onchocerca volvulus OVOC4566  
Schistosoma japonicum Sjp_0022350   G patch domain and KOW motifs-containing protein, putative
Schistosoma japonicum Sjp_0303950   G patch domain and KOW motifs-containing protein, putative
Schistosoma mansoni Smp_052140   hypothetical protein
Schmidtea mediterranea mk4.004808.02  
Schmidtea mediterranea mk4.008155.00  

Essentiality

Bm1_36705 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_F53B2.1 Caenorhabditis elegans slow growth wormbase
CELE_R11A8.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_R11A8.2 Caenorhabditis elegans larval arrest wormbase
CELE_R11A8.2 Caenorhabditis elegans slow growth wormbase
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_36705 (Brugia malayi), KOW motif family protein
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