Detailed view for Bm1_52420

Basic information

TDR Targets ID: 236572
Brugia malayi, xanthine/uracil permease family protein
Source Database / ID:  GenBank

pI: 7.9276 | Length (AA): 561 | MW (Da): 60902 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 11

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00860   Permease family

Gene Ontology

Mouse over links to read term descriptions.
GO:0022857   transmembrane transporter activity  
GO:0016020   membrane  
GO:0005215   transporter activity  
GO:0055085   transmembrane transport  
GO:0006810   transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
29 497 5i6c (A) 67 542 20.00 0 0.86 1.03811 -0.01
29 494 5i6c (A) 67 539 26.00 0 0.89 0.98036 0.41
161 212 2yc4 (C) 27 100 33.00 0.69 0.03 0.0253916 3.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_126747)

Species Accession Gene Product
Arabidopsis thaliana AT5G62890   Xanthine/uracil permease family protein
Arabidopsis thaliana AT1G65550   xanthine/uracil permease family protein
Arabidopsis thaliana AT1G60030   nucleobase-ascorbate transporter 7
Arabidopsis thaliana AT2G34190   nucleobase-ascorbate transporter 2
Arabidopsis thaliana AT5G25420   xanthine/uracil/vitamin C permease
Arabidopsis thaliana AT5G49990   xanthine/uracil permease family protein
Arabidopsis thaliana AT2G05760   nucleobase-ascorbate transporter 1
Arabidopsis thaliana AT1G49960   nucleobase-ascorbate transporter 4
Arabidopsis thaliana AT1G10540   nucleobase-ascorbate transporter 8
Arabidopsis thaliana AT2G26510   nucleobase-ascorbate transporter 3
Brugia malayi Bm1_52420   xanthine/uracil permease family protein
Candida albicans CaO19.2882   potential purine permease similar to E.nidulans uapA (CAA50681) uric acid-xanthine permease and uapC (CAA56190) purine permease
Candida albicans CaO19.10400   potential purine permease similar to E.nidulans uapA (CAA50681) uric acid-xanthine permease and uapC (CAA56190) purine permease
Caenorhabditis elegans CELE_T07G12.2   Protein T07G12.2
Caenorhabditis elegans CELE_C51E3.6   Protein C51E3.6
Caenorhabditis elegans CELE_R11E3.2   Protein R11E3.2
Caenorhabditis elegans CELE_T07G12.5   Protein T07G12.5, isoform B
Dictyostelium discoideum DDB_G0277515   xanthine/uracil permease family protein
Dictyostelium discoideum DDB_G0285299   xanthine/uracil permease family protein
Drosophila melanogaster Dmel_CG6293   CG6293 gene product from transcript CG6293-RB
Escherichia coli b3654   xanthine permease
Escherichia coli b2497   uracil permease
Escherichia coli b2888   uric acid permease
Escherichia coli b2882   xanthine permease
Escherichia coli b1006   pyrimidine permease
Homo sapiens ENSG00000170482   solute carrier family 23 (ascorbic acid transporter), member 1
Homo sapiens ENSG00000089057   solute carrier family 23 (ascorbic acid transporter), member 2
Loa Loa (eye worm) LOAG_03105   xanthine/uracil permease
Mus musculus ENSMUSG00000027340   solute carrier family 23 (nucleobase transporters), member 2
Mus musculus ENSMUSG00000024354   solute carrier family 23 (nucleobase transporters), member 1
Oryza sativa 4346932   Os09g0381100
Oryza sativa 4330689   Os02g0741800
Oryza sativa 4334620   Os03g0823800
Oryza sativa 4333795   Os03g0694500
Oryza sativa 4325616   Os01g0759900
Oryza sativa 4352654   Os12g0583900
Oryza sativa 4346706   Os09g0320400
Oryza sativa 4345589   Os08g0420600
Onchocerca volvulus OVOC6608  
Schistosoma mansoni Smp_111470   purine permease
Schmidtea mediterranea mk4.047532.00  
Schmidtea mediterranea mk4.031022.00   Solute carrier family 23 member 3
Schmidtea mediterranea mk4.006292.00   Solute carrier family 23 member 3
Schmidtea mediterranea mk4.006423.03   Solute carrier family 23 member 3
Schmidtea mediterranea mk4.050532.02  
Schmidtea mediterranea mk4.005793.00   Solute carrier family 23 member 3

Essentiality

Bm1_52420 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b1006 Escherichia coli non-essential goodall
b2497 Escherichia coli non-essential goodall
b2882 Escherichia coli non-essential goodall
b2888 Escherichia coli non-essential goodall
b3654 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_52420 (Brugia malayi), xanthine/uracil permease family protein
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