pI: 8.3036 |
Length (AA): 406 |
MW (Da): 47474 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
9 | 404 | 5ubp (B) | 5 | 441 | 18.00 | 0.00027 | 1 | 1.10787 | -0.15 |
212 | 405 | 3t5x (A) | 205 | 398 | 60.00 | 0 | 1 | 1.33353 | -1.66 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_128308)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G19560 | enhanced ethylene response protein 5 |
Babesia bovis | BBOV_III003080 | conserved hypothetical protein |
Babesia bovis | BBOV_III006050 | conserved hypothetical protein |
Brugia malayi | Bm1_16505 | HT004 protein |
Candida albicans | CaO19.11427 | similar to S. cerevisiae YJR084W |
Candida albicans | CaO19.3945 | similar to S. cerevisiae YJR084W |
Caenorhabditis elegans | CELE_C27F2.10 | Protein C27F2.10 |
Cryptosporidium hominis | Chro.50292 | PINT domain protein (proteasomal subunit) PFB0240w |
Cryptosporidium parvum | cgd5_950 | Csn12p/Rpn3p family protein; component of the COP9 signalsome |
Dictyostelium discoideum | DDB_G0284241 | proteasome component region PCI domain-containing protein |
Drosophila melanogaster | Dmel_CG7351 | PCI domain-containing protein 2 |
Echinococcus granulosus | EgrG_000822100 | PCI domain containing protein 2 |
Echinococcus granulosus | EgrG_000822200 | Proteasome PCI domain containing protein 2 |
Entamoeba histolytica | EHI_078210 | PCI domain containing protein |
Echinococcus multilocularis | EmuJ_000822100 | PCI domain containing protein 2 |
Echinococcus multilocularis | EmuJ_000822200 | Proteasome PCI domain containing protein 2 |
Homo sapiens | ENSG00000126226 | PCI domain containing 2 |
Loa Loa (eye worm) | LOAG_03216 | HT004 protein |
Mus musculus | ENSMUSG00000038542 | PCI domain containing 2 |
Neospora caninum | NCLIV_024010 | hypothetical protein |
Oryza sativa | 4346949 | Os09g0386400 |
Onchocerca volvulus | OVOC2570 |
|
Plasmodium berghei | PBANKA_0303100 | PCI domain-containing protein, putative |
Plasmodium falciparum | PF3D7_0205400 | PCI domain-containing protein, putative |
Plasmodium knowlesi | PKNH_0415500 | PCI domain-containing protein, putative |
Plasmodium vivax | PVX_003700 | hypothetical protein, conserved |
Plasmodium yoelii | PY02526 | PINT domain protein |
Saccharomyces cerevisiae | YJR084W | hypothetical protein |
Schistosoma japonicum | Sjp_0076820 | PCI domain-containing protein 2, putative |
Schistosoma japonicum | Sjp_0304070 | ko:K01047 phospholipase A2 [EC3.1.1.4], putative |
Schistosoma mansoni | Smp_148440 | hypothetical protein |
Schmidtea mediterranea | mk4.000383.04 | |
Schmidtea mediterranea | mk4.000383.03 | |
Schmidtea mediterranea | mk4.000383.05 | |
Toxoplasma gondii | TGME49_264060 | PCI domain-containing protein |
Theileria parva | TP02_0358 | hypothetical protein, conserved |
Trichomonas vaginalis | TVAG_389640 | PCI domain-containing protein, putative |
Trichomonas vaginalis | TVAG_235430 | PCI domain-containing protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_C27F2.10 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_C27F2.10 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_C27F2.10 | Caenorhabditis elegans | slow growth | wormbase |
TGME49_264060 | Toxoplasma gondii | Probably essential | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.